1 As filed with the Securities and Exchange Commission on May 10, 2000 REGISTRATION NO. 333- SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ---------------- FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ---------------- PROTEIN DESIGN LABS, INC. Exact name of Registrant as specified in its charter) DELAWARE 94-3023969 (State or other jurisdiction of (I.R.S. Employer incorporation or organization) Identification No.) 34801 CAMPUS DRIVE FREMONT, CALIFORNIA 94555 (510) 574-1400 (Address, including zip code, and telephone number, including area code, of Registrant's principal executive offices) ---------------- DOUGLAS O. EBERSOLE 34801 CAMPUS DRIVE FREMONT, CALIFORNIA 94555 (510) 574-1400 (Name, address, including zip code, and telephone number, including area code, of agent for service) Copies to: Gregory M. Gallo, Esq. Gray Cary Ware & Freidenrich LLP 400 Hamilton Avenue Palo Alto, California 94301 ---------------- APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As soon as practicable after this Registration Statement becomes effective. If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box: [ ] If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box: [X] If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. [ ] If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. [ ] If delivery of the prospectus is expected to be made pursuant to Rule 434 under the Securities Act, please check the following box. [ ] (1) Represents the aggregate principal amount of the notes issued by the Registrant. (2) Estimated solely for the purpose of calculating the Registration Fee pursuant to Rule 457(i) under the Securities Act of 1933, as amended. (3) Exclusive of accrued interest and distributions, if any. (4) Such number represents the number of shares of Common Stock as are initially issuable upon conversion of the 5.50% Convertible Subordinated Notes due February 15, 2007 registered hereby and, pursuant to Rule 416 under the Securities Act of 1933 as amended, such indeterminate number of shares of Common Stock as may be issued from time to time upon conversion of the Notes as a result of the antidilution provisions thereof. (5) No additional consideration will be received for the common stock and therefore, pursuant to Rule 457(i), no registration fee is required for these shares. THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(a) OF THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SUCH SECTION 8(a), MAY DETERMINE.
CALCULATION OF REGISTRATION FEE ============================================================================================================= Title of Each Class of Amount to be Proposed Maximum Proposed Maximum Amount of Securities to be Registered Registered Aggregate Price Per Aggregate Offering Registration Security Price Fee - ------------------------------------------------------------------------------------------------------------- 5.50% Convertible $150,000,000 (1) 100% (2)(3) $150,000,000 $39,600 Subordinated Notes due (2) February 15, 2007 - ------------------------------------------------------------------------------------------------------------- Common Stock, $.01 par value 993,377 shares (4) ----(5) ============================================================================================================= 2 Information contained herein is subject to completion or amendment. A registration statement relating to these securities has been filed with the Securities and Exchange Commission. These securities may not be sold nor may offers to buy be accepted prior to the time the registration statement becomes effective. This prospectus shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of these securities in any State in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state. PROSPECTUS SUBJECT TO COMPLETION, DATED MAY 10, 2000 $150,000,000 PROTEIN DESIGN LABS, INC. 5.50% CONVERTIBLE SUBORDINATED NOTES DUE FEBRUARY 15, 2007 993,337 SHARES OF COMMON STOCK ISSUABLE ON CONVERSION OF THE NOTES - -------------------------------------------------------------------------------- This prospectus relates to 5.50% Convertible Subordinated Notes due February 15, 2007 of Protein Design Labs, Inc., a Delaware corporation (PDL), held by certain security holders who may offer for sale the notes and shares of our common stock into which the notes are convertible at any time, at market prices prevailing at the time of sale or at privately negotiated prices. The selling security holders may sell the notes or the common stock directly to purchasers or through underwriters, broker-dealers or agents, that may receive compensation in the form of discounts, concessions or commissions. We will not receive any proceeds from this offering. You may convert the notes into shares of our common stock at any time before their maturity unless we have previously redeemed or repurchased them. The notes will be due on February 15, 2007. The conversion rate is 6.6225 shares per each $1,000 principal amount of notes, subject to adjustment in certain circumstances. This is equivalent to a conversion price of approximately $151.00 per share. The notes are not listed on any securities exchange or included in any automated quotation system. The notes are eligible for trading in the Private Offerings, Resale and Trading through Automated Linkages (PORTAL) Market of the National Association of Securities Dealers, Inc. Our common stock is quoted on The Nasdaq National Market under the symbol "PDLI." On April 25, 2000, the last reported bid price for our common stock as quoted on The Nasdaq National Market was $78.875 per share. We will pay interest on the notes on February 15 and August 15 of each year. The first interest payment will be made on August 15, 2000. The notes are subordinated in right of payment to all senior debt of PDL. The notes will be issued only in denominations of $1,000 and integral multiples of $1,000. We have the right to redeem all or a portion of the notes that have not been previously converted at the redemption prices set forth in this prospectus on or after February 15, 2003. In the event of a Change in Control, as described in this prospectus, you may require us to repurchase any notes held by you. INVESTING IN THE NOTES AND THE COMMON STOCK INVOLVES RISK. SEE "RISK FACTORS" BEGINNING ON PAGE 15. THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION NOR HAS THE COMMISSION PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE. The date of this Prospectus is May __, 2000. 2 3 PRODUCTS IN DEVELOPMENT The following table summarizes the potential therapeutic indications, development status and commercial rights for our approved product and some of our most advanced product candidates and is qualified in its entirety by the more detailed information appearing elsewhere in this prospectus. The development and commercialization of our product candidates is subject to numerous risks and uncertainties. See "Risk Factors." - ---------- (1) Hoffmann-La Roche Inc. and its affiliates (Roche) have marketing rights to Zenapax for transplantation. PDL and Roche share marketing rights for Zenapax's autoimmune indications. (2) The U.S. Phase II clinical trials for kidney transplant rejection are currently on hold. (3) Scil Biomedicals GmbH (formerly BioNet Pharma) has European development and marketing rights to the SMART Anti-L-Selectin Antibody and is conducting the Phase IIa trial. (4) PDL licensed the humanized anti-IL-4 antibody from SmithKline Beecham Corporation, which has the right to opt in after the Phase II trial and share development costs and profits from product sales. Protein Design Labs, the PDL logo and SMART are registered trademarks of PDL. Zenapax is a registered U.S. trademark of Roche. All other company names and trademarks included in this prospectus are trademarks, registered trademarks or trade names of their respective owners. 3
ANTIBODY PRODUCT INDICATION(s) STATUS - ---------------- ------------- ------ Zenapax(R)(1) Kidney transplant rejection Marketed Psoriasis Phase II Uveitis Phase I/II SMART(TM) M195 Acute myeloid leukemia Phase III SMART Anti-CD3 Transplantation Phase II(2) Psoriasis Phase I/II Graft-versus-host disease Phase I SMART Anti-L-Selectin(3) Trauma Phase IIa SMART 1D10 Non-Hodgkins B-cell lymphoma Phase I SMART Anti-E/P-Selectin Stroke, asthma Phase I in healthy volunteers complete Humanized Anti-IL-4(4) Asthma Phase I SMART Anti-Gamma Interferon Autoimmune diseases Phase I 4 RISK FACTORS AND INFORMATION REGARDING FORWARD-LOOKING STATEMENTS IN ADDITION TO THE OTHER INFORMATION CONTAINED IN THIS PROSPECTUS, INVESTORS SHOULD CAREFULLY CONSIDER THE RISK FACTORS DISCLOSED IN THIS PROSPECTUS, INCLUDING THOSE BEGINNING ON PAGE 15, IN EVALUATING AN INVESTMENT IN THE NOTES OR THE COMMON STOCK ISSUABLE UPON CONVERSION OF THE NOTES. THIS PROSPECTUS INCLUDES "FORWARD-LOOKING STATEMENTS" WITHIN THE MEANING OF SECTION 27A OF THE SECURITIES ACT AND SECTION 21E OF THE EXCHANGE ACT. ALL STATEMENTS OTHER THAN STATEMENTS OF HISTORICAL FACTS ARE "FORWARD-LOOKING STATEMENTS" FOR PURPOSES OF THESE PROVISIONS, INCLUDING ANY PROJECTIONS OF EARNINGS, REVENUES OR OTHER FINANCIAL ITEMS, ANY STATEMENTS OF THE PLANS AND OBJECTIVES OF MANAGEMENT FOR FUTURE OPERATIONS, ANY STATEMENTS CONCERNING PROPOSED NEW PRODUCTS OR SERVICES, ANY STATEMENTS REGARDING FUTURE ECONOMIC CONDITIONS OR PERFORMANCE, AND ANY STATEMENT OF ASSUMPTIONS UNDERLYING ANY OF THE FOREGOING. IN SOME CASES, FORWARD-LOOKING STATEMENTS CAN BE IDENTIFIED BY THE USE OF TERMINOLOGY SUCH AS "MAY", "WILL", "EXPECTS", "PLANS", "ANTICIPATES", "ESTIMATES", "POTENTIAL", OR "CONTINUE" OR THE NEGATIVE THEREOF OR OTHER COMPARABLE TERMINOLOGY. ALTHOUGH WE BELIEVE THAT THE EXPECTATIONS REFLECTED IN THE FORWARD-LOOKING STATEMENTS CONTAINED HEREIN ARE REASONABLE, THERE CAN BE NO ASSURANCE THAT SUCH EXPECTATIONS OR ANY OF THE FORWARD-LOOKING STATEMENTS WILL PROVE TO BE CORRECT, AND ACTUAL RESULTS COULD DIFFER MATERIALLY FROM THOSE PROJECTED OR ASSUMED IN THE FORWARD-LOOKING STATEMENTS. OUR FUTURE FINANCIAL CONDITION AND RESULTS OF OPERATIONS, AS WELL AS ANY FORWARD-LOOKING STATEMENTS, ARE SUBJECT TO INHERENT RISKS AND UNCERTAINTIES, INCLUDING BUT NOT LIMITED TO THE RISK FACTORS SET FORTH BELOW, AND FOR THE REASONS DESCRIBED ELSEWHERE IN THIS PROSPECTUS. ALL FORWARD-LOOKING STATEMENTS AND REASONS WHY RESULTS MAY DIFFER INCLUDED IN THIS PROSPECTUS ARE MADE AS OF THE DATE HEREOF, AND WE ASSUME NO OBLIGATION TO UPDATE THESE FORWARD-LOOKING STATEMENTS OR REASONS WHY ACTUAL RESULTS MIGHT DIFFER. 4 5 TABLE OF CONTENTS We were incorporated in Delaware in 1986. Our principal executive offices are located at 34801 Campus Drive, Fremont, California 94555 and our phone number is (510) 574-1400. We maintain a home page at www.pdl.com. 5
Page Summary ........................................................................... 6 Selected Financial Data............................................................ 13 Risk Factors....................................................................... 15 Use of Proceeds.................................................................... 30 Price Range of Common Stock........................................................ 30 Dividend Policy.................................................................... 30 Description of the Notes........................................................... 31 Description of Capital Stock....................................................... 49 Certain Federal Income Tax Considerations.......................................... 50 Selling Security Holders........................................................... 57 Plan of Distribution............................................................... 60 Legal Matters...................................................................... 61 Experts............................................................................ 61 Available Information.............................................................. 61 Incorporation of Certain Documents by Reference.................................... 61 Limitation of Liability and Indemnification Matters................................ 62 --------------------------------------- 6 SUMMARY This summary highlights information contained in other parts of this prospectus. Because it is a summary, it does not contain all of the information that you should consider before investing in the notes and common stock. You should read the entire prospectus carefully. PROTEIN DESIGN LABS, INC. PDL is a leader in the development of humanized monoclonal antibodies for the prevention and treatment of disease. We have licensed rights to our first humanized antibody product, Zenapax, to Roche, which markets it for the prevention of kidney transplant rejection. We are also testing Zenapax for the treatment of autoimmune disease. In addition, we have announced seven other humanized antibodies in clinical development for autoimmune and inflammatory conditions, transplantation and cancer. PDL has fundamental patents in the U.S., Europe and Japan, which we believe cover most humanized antibodies. To date we have licensed eleven companies under these patents for humanized antibodies that they have developed. We receive royalties on sales of the two humanized antibodies developed by other companies that are currently being marketed. THE OPPORTUNITY During the past several years, there has been a resurgence of interest in the medical and commercial potential of monoclonal antibodies. The Food and Drug Administration has approved eight therapeutic antibodies, six of them in the last three years, with total sales in 1999 in excess of $1.0 billion. This resurgence has been made possible by the use of genetic engineering to create improved forms of antibodies. In particular, we developed and patented computer-aided technology to make "humanized" antibodies, which are antibodies that capture the benefits of traditional mouse-derived monoclonal antibodies while avoiding their limitations in treating humans. Three of the therapeutic antibodies approved for marketing by the FDA are humanized antibodies, and more than 30 other humanized antibodies are currently in clinical trials. These humanized antibodies address many large markets, including cancer, stroke, heart disease, asthma, and autoimmune diseases such as psoriasis, multiple sclerosis and rheumatoid arthritis. A number of these antibodies have entered or completed the later phases of clinical development and, depending on satisfactory clinical results, may reach the marketplace in the next few years. As discussed further below, many of these antibodies are licensed under our patents, or are being developed by our company. In addition, with the sequencing of the human genome nearly complete, large numbers of new, potentially important therapeutic targets are being identified. Humanized antibodies can be routinely and reliably developed against almost any cell surface or extracellular target. Hence, we believe that humanized antibodies will be a key part of the next generation of pharmaceutical products. 6 7 STRATEGY Our objective is to leverage our product pipeline and patent portfolio in the field of antibodies to become a fully-integrated, profitable, research-based biopharmaceutical company. We derive revenues, and expect to derive revenues in the future, from three major sources: - Sales of products that we have developed. We receive royalties on sales of Zenapax by our licensee, Roche. We have announced seven other humanized antibodies in clinical development. We plan to market some of our products, once approved, in North America, especially for specialty markets such as cancer that we believe can be effectively serviced with a relatively small sales force. We may license marketing rights for some antibodies or some geographic areas to other pharmaceutical companies. - Royalties from the sale of humanized antibodies developed by other companies. We license our patents covering humanized antibodies in return for license fees, annual maintenance payments and royalties on product sales. The two humanized antibodies currently approved by the FDA in addition to Zenapax are licensed under our patents, and we receive royalties on their sales. These antibodies are Genentech's Herceptin(R) and MedImmune's Synagis(R), which had reported sales totaling approximately $480 million in 1999. We have licensed nine other companies to date for humanized antibodies they are developing. - Research and development contracts with other companies. We humanize antibodies for other companies in return for upfront fees, milestone payments and royalties on any product sales. In some cases we also receive the right to co-promote these products in designated territories. We also sometimes license out marketing rights to a humanized antibody that we are developing, and then typically receive upfront fees and milestone payments and/or research funding, in addition to royalties on any product sales by our licensee. PATENT OPPOSITION PROCEEDINGS Our patents for humanized antibodies are being opposed in patent office proceedings in Europe and Japan, and a successful challenge could limit our future revenues from licensing these patents. At an oral hearing in March 2000, the Opposition Division of the European Patent Office decided to revoke the broad claims in our first European patent pertaining generally to antibody humanization. We plan to appeal the decision of the Opposition Division to the Technical Board of Appeals of the European Patent Office. See "Risk Factors -- Our humanization patents are being opposed and a successful challenge could limit our future revenues." PRODUCTS IN DEVELOPMENT We have the following products under clinical development. We usually refer to the humanized antibodies that we have made as SMART antibodies. - Zenapax. The FDA approved Zenapax in December 1997 for the prevention of kidney transplant rejection. Zenapax was the first humanized antibody to be approved anywhere in the world. Our licensee Roche sells this product in the U.S., Europe and other territories for the transplant indication. Zenapax works by blocking the activation of T 7 8 cells, which play a key role in both transplant rejection and autoimmune disease. Because of its specificity, Zenapax is the first effective immunosuppressive drug without significant side effects. As a result, we believe Zenapax may be useful for the long-term treatment of autoimmune diseases such as psoriasis and multiple sclerosis. In 1999, we reacquired from Roche specific development and marketing rights to Zenapax for autoimmune diseases. We will fund costs of clinical trials for Zenapax in autoimmune diseases. In return, we have the right to market Zenapax for approved autoimmune indications in the U.S. and Canada, and will receive a major portion of the revenues from sales for these diseases. Roche will continue to manufacture Zenapax and pay for the cost of goods from its share of the revenues. In Europe and other countries, Roche can elect to market Zenapax for approved autoimmune indications or to allow us to market it, and revenues will be shared. Zenapax is currently in two Phase II trials in psoriasis, a common autoimmune disease of the skin. We plan to conduct additional trials for psoriasis and other autoimmune diseases. Also, in an early stage clinical trial for uveitis, an autoimmune disease of the eye, Zenapax was safely administered to patients for one year and was effective in controlling the disease in most patients, some of whom have continued to receive Zenapax for up to three years. - SMART M195 Antibody. This antibody has completed a Phase II trial and is now in a Phase III trial for the treatment of acute myeloid leukemia, a disease that has approximately 10,000 new cases in the U.S. each year and has a high mortality rate. If the results of the trial are positive, we expect to file for marketing approval. - SMART Anti-CD3 Antibody. We are developing this antibody for the treatment of autoimmune diseases and for transplantation. SMART Anti-CD3 is directed to the same target as a mouse antibody, Orthoclone OKT(R)3, which is currently marketed for transplantation, but SMART Anti-CD3 has been humanized and engineered to induce fewer side effects. Although both SMART Anti-CD3 and Zenapax may target some of the same diseases, we believe they may have complementary roles in medical treatment. SMART Anti-CD3 may be more potent than Zenapax, but may not be suitable for chronic administration, so it may be most useful to treat acute episodes of autoimmune disease and to induce remissions. Zenapax may be useful to maintain the remissions for longer periods. SMART Anti-CD3 is currently in clinical trials for psoriasis, transplant rejection and graft-versus-host disease. The U.S. clinical trials for kidney transplant indications are currently on hold pending resolution of outstanding issues with the FDA. - SMART Anti-L-Selectin Antibody. This antibody may be useful for preventing the multiple organ failure and mortality that often follows severe injury (trauma). In 1999, we licensed European marketing rights for this antibody to Scil Biomedicals, a privately held European biotechnology company. Scil paid us a licensing fee and agreed to conduct and pay for clinical trials in Europe and to provide us with the data; in return, we are making milestone payments to Scil on the achievement of defined clinical and regulatory goals. Scil has completed a Phase I trial of SMART Anti-L-Selectin and is now conducting a Phase IIa trial for treatment of trauma. If the results from that Phase IIa trial are encouraging, we may initiate clinical development in the U.S. 8 9 - SMART 1D10 Antibody. The National Cancer Institute is sponsoring a Phase I trial of this antibody for non-Hodgkins B-cell lymphoma. If the results are sufficiently encouraging, we plan to conduct a potentially pivotal Phase II trial. SMART 1D10 is directed to a different target on B cells than Rituxan(R), the antibody currently marketed for non-Hodgkins lymphoma, and thus may provide an alternative therapy. In the U.S. and Europe, approximately 560,000 patients have this disease and 100,000 new cases occur annually. - Humanized Anti-IL-4 Antibody. We licensed this antibody, for the potential treatment of asthma and allergy, from SmithKline Beecham (SB) in 1999. The humanized anti-IL-4 antibody blocks the effects of interleukin 4, which is believed to play a key role in initiating the series of biological processes that lead to allergy and asthma. SB began a Phase I trial of the humanized anti-IL-4 antibody, which we have reinitiated. If Phase I is successfully completed, we then plan to conduct a Phase II trial in asthma patients. We will conduct and pay for initial clinical trials of the humanized anti-IL-4 antibody and pay SB to manufacture the antibody. SB has agreed to make milestone payments to us upon the achievement of specified clinical goals. At the completion of a specified Phase II trial, SB may choose to pay us an "opt-in" fee. In that case, we and SB will share future development costs and profits from any product sales. If SB elects not to opt in, we will have the right to develop and market the antibody. Concurrently, we granted SB an exclusive license under our humanization patents for a humanized anti-IL-5 antibody that they are developing, for which SB paid us a licensing fee. We also granted SB options to obtain non-exclusive licenses under these patents for up to three additional antibodies. These arrangements with SB illustrate our ability to leverage our patent portfolio to obtain rights to a potentially important product. - SMART Anti-Gamma Interferon Antibody. This antibody targets gamma interferon, a protein that stimulates several types of white blood cells and that may be involved in some autoimmune diseases. In February 2000, we began a Phase I trial of SMART Anti-Gamma Interferon in normal volunteers. In the future, we may initiate clinical trials in one or more autoimmune diseases, particularly Crohn's disease. - SMART Anti-E/P-Selectin Antibody. This antibody targets substances on the inside of blood vessels that may be involved in inflammation. We have completed a Phase I of SMART Anti-E/P-Selectin in healthy volunteers which showed that the antibody is safe in a range of doses. We have retained worldwide rights to SMART Anti-E/P-Selectin and are seeking a partner for its further development. 9 10 THE OFFERING 10
SECURITIES OFFERED.................... $150,000,000 aggregate principal amount of 5.50% Convertible Subordinated Notes due February 15, 2007 and shares of Common Stock issuable upon conversion of the notes. INTEREST.............................. We will pay interest on the notes semi-annually on February 15 and August 15 of each year, commencing August 15, 2000. CONVERSION............................ The notes will be convertible at the option of the holder into shares of common stock at a conversion rate of 6.6225 shares of common stock per $1,000 principal amount of notes, which is equivalent to a conversion price of approximately $151.00 per share. The conversion rate is subject to adjustment. The notes will be convertible at any time before the close of business on the maturity date, unless we have previously redeemed or repurchased the notes; provided, however, that if a note is called for redemption or repurchase, a holder of the note will be entitled to convert the note at any time before the close of business on the date fixed for redemption or repurchase, as the case may be. See "Description of the Notes--Conversion Rights." SUBORDINATION......................... The notes are subordinated to our present and future Senior Debt, as that term is defined in this prospectus. The notes are also effectively subordinated in right of payment to all indebtedness and other liabilities of our subsidiaries. As of December 31, 1999, we had no Senior Debt outstanding, and our subsidiaries' indebtedness and other liabilities totalled approximately $10.1 million. The indenture under which the notes will be issued (the Indenture) will not restrict our incurrence of indebtedness, including Senior Debt, or our subsidiaries' incurrence of indebtedness. See "Description of the Notes--Subordination." GLOBAL NOTE; BOOK ENTRY SYSTEM ........................... The notes may only be issued in fully registered form without interest coupons and in minimum denominations of $1,000. The notes are evidenced by one or more global notes deposited with the trustee for the notes, as custodian for The Depository Trust Company (DTC). Beneficial interests in the global note are shown on, and transfers of those beneficial interests can only be made 11 11
through, records maintained by DTC and its participants. See "Description of the Notes--Form, Denomination, Transfer, Exchange and Book--Entry Procedures." OPTIONAL REDEMPTION................... We may redeem the notes, at our option, in whole or in part, on or after February 15, 2003, at the redemption prices set forth in this prospectus plus accrued interest to the redemption date. See "Description of the Notes--Optional Redemption." REPURCHASE AT OPTION OF HOLDERS UPON A CHANGE OF CONTROL............ Upon a Change in Control, as that term is defined in this prospectus, you will have the right, subject to certain conditions and restrictions, to require us to repurchase your notes, in whole or in part, at 100% of their principal amount, plus accrued interest to the repurchase date. The repurchase price is payable in cash or, at our option, in shares of common stock. However, we may pay the repurchase price in common stock only if we satisfy prescribed conditions. If we pay the repurchase price in common stock, the common stock will be valued at 95% of the average of the high and low sales prices of the common stock for each of the five trading days ending with the third trading day prior to the repurchase date. A Change in Control could be an event of default under the Senior Debt. In those circumstances, the subordination provisions of the Indenture would likely prevent us from repurchasing the notes until the Senior Debt is paid in full. See "Description of the Notes-Repurchase at Option of Holders Upon a Change in Control." USE OF PROCEEDS....................... We will not receive any proceeds from the sale of the notes or the shares offered by this prospectus. See "Selling Security Holders." EVENTS OF DEFAULT..................... The following are events of default under the Indenture: - we fail to pay the principal of or any premium on these notes when due, whether or not the payment is prohibited by the Indenture's subordination provisions - we fail to pay any interest on these notes when due and that default continues for 30 days, whether or not the payment is prohibited by the Indenture's subordination provisions - we fail to give the notice that we are required to give 12 12
if there is a Change in Control, whether or not the notice is prohibited by the Indenture's subordination provisions - we fail to perform any other covenant in the Indenture and that failure continues for 60 days after written notice to us by the trustee or the holders of at least 25% in aggregate principal amount of outstanding notes - we fail to pay when due the principal of any indebtedness for money borrowed by us or any of our subsidiaries in excess of $10 million if the indebtedness is not discharged and such failure continues for 20 days or more, or, if such indebtedness has been accelerated, such acceleration is not annulled, within 30 days after written notice to us by the trustee or the holders of at least 25% in aggregate principal amount of the outstanding notes, and - events of bankruptcy, insolvency or reorganization with respect to us and our significant subsidiaries specified in the Indenture. See "Description of Notes--Events of Default." NASDAQ NATIONAL MARKET SYMBOL FOR OUR COMMON STOCK......... PDLI REGISTRATION RIGHTS................... Upon any failure by us to comply with certain of our obligations under the Registration Rights Agreement, additional interest will be payable on the notes. LISTING............................... The notes are eligible for trading in the Private Offerings, Resale and Trading through Automated Linkages (PORTAL) Market of the NASD. RISK FACTORS.......................... You should read "Risk Factors", beginning on page 15 of this prospectus, so that you understand the risks associated with an investment in the notes and the common stock that is to be issued on conversion of the notes. 13 SELECTED FINANCIAL DATA The following selected financial data for each of the three years in the period ended December 31, 1999, and as of December 31, 1998 and 1999 has been taken, or is derived from, and should be read with our financial statements, including the notes thereto, that have been audited by Ernst & Young LLP, independent auditors, and are incorporated by reference herein and included in our Annual Report on Form 10-K for the year ended December 31, 1999. The selected financial data for the years ended December 31, 1995 and 1996, and as of December 31, 1995, 1996 and 1997, has been taken or is derived from our audited financial statements that have not been included or incorporated by reference in this prospectus. Historical results are not necessarily indicative of future results.
YEAR ENDED DECEMBER 31, -------------------------------------------------------------------- 1995 1996 1997 1998 1999 -------- -------- -------- -------- -------- (IN THOUSANDS, EXCEPT PER SHARE DATA AND RATIOS) STATEMENTS OF OPERATIONS DATA: Revenues (1): Revenue under agreements with third parties ................................................. $ 11,408 $ 16,500 $ 11,137 $ 21,325 $ 26,811 Interest and other income ............................... 6,205 6,100 9,118 9,503 8,943 -------- -------- -------- -------- -------- Total revenues ......................................... 17,613 22,600 20,255 30,828 35,754 Costs and expenses: Research and development ................................ 20,803 28,795 25,614 31,645 36,090 General and administrative .............................. 5,163 5,601 6,629 8,685 9,842 Special charge(2) ....................................... -- -- 11,887 -- -- Interest expense ........................................ 1 -- -- -- 155 -------- -------- -------- -------- -------- Total costs and expenses .............................. 25,967 34,396 44,130 40,330 46,087 -------- -------- -------- -------- -------- Net loss .................................................. $ (8,354) $(11,796) $(23,875) $ (9,502) $(10,333) ======== ======== ======== ======== ======== Net loss per share(3) ..................................... $ (0.54) $ (0.76) $ (1.35) $ (0.51) $ (0.55) ======== ======== ======== ======== ======== Shares used in computation of net loss per share ............................................... 15,343 15,604 17,649 18,525 18,698 Ratio of earnings to fixed charges(4) ..................... -- -- -- -- -- (1) In December 1999, the Securities and Exchange Commission issued Staff Accounting Bulletin No. 101, "Revenue Recognition in Financial Statements" (SAB 101). We are evaluating the effects, if any, that the adoption of SAB 101 in the second quarter of 2000 may have on the results of our operations or our financial position. We have been advised that the Securities and Exchange Commission intends to provide additional guidance during the second quarter of 2000 with respect to the implementation of SAB 101. It is currently unknown whether such guidance and 13
DECEMBER 31, ------------------------------------------------------------------------- 1995 1996 1997 1998 1999 --------- --------- --------- --------- --------- (IN THOUSANDS) BALANCE SHEET DATA: Cash, cash equivalents and investments .............. $ 107,065 $ 99,667 $ 163,655 $ 143,439 $ 137,237 Working capital ..................................... 43,522 74,221 66,490 82,394 22,669 Total assets ........................................ 116,412 110,331 175,026 171,850 182,551 Accumulated deficit ................................. (23,711) (35,507) (59,382) (68,884) (79,217) Long-term obligations, exclusive of current portion ........................................... -- -- -- -- -- Total stockholders' equity .......................... 112,856 105,112 168,468 162,496 164,743 14 implementation of SAB 101 will require us to revise our revenue recognition practices or to restate revenues for the first quarter of 2000. (2) Represents a non-cash special charge of approximately $11.9 million related to the extensions of the term of all outstanding stock options held by employees, officers, directors and consultants to PDL that were granted prior to February 1995, with the single exception of stock options granted to one non-employee director. The extension conforms the term of previously granted stock options, which was six years, to those granted since February 1995, ten years. (3) For a description of the computation of net loss per share, see Note 1 to the Financial Statements included in our Annual Report on Form 10-K for the year ended December 31, 1999, incorporated by reference in this prospectus. (4) For the purposes of computing the ratio of earnings to fixed charges, earnings consist of income (loss) before provision for income taxes plus fixed charges. Fixed charges consist of interest charges, amortization of debt expense and discount or premium related to indebtedness, whether expensed or capitalized, and that portion of rental payments under operating leases we believe to be representative of interest. Earnings for the years ended December 31, 1995, 1996, 1997, 1998 and 1999, were insufficient to cover fixed charges by $8,354, $11,796, $23,875, $9,502, and $10,333, respectively (in thousands). 14 15 RISK FACTORS You should carefully consider the following factors and other information in this prospectus before deciding to invest in the notes or the common stock issuable upon conversion of the notes. If any of the following risks actually occurs, it could materially harm our business, financial condition or operating results. In such case, the trading price of the notes and our common stock could decline and you may lose part or all of your investment. WE HAVE A HISTORY OF OPERATING LOSSES AND MAY NOT ACHIEVE PROFITABILITY. Our expenses have generally exceeded revenues. As of December 31, 1999, we had an accumulated deficit of approximately $79.2 million. We believe that our losses may increase because of the extensive resource commitments required to achieve regulatory approval and commercial success for any individual product. For example, over the next several years, we will incur substantial additional expenses as we continue to develop and manufacture our potential products, invest in new research areas and improve and expand our manufacturing capabilities. Since we or our collaborative partners or licensees may not be able to successfully develop additional products, obtain required regulatory approvals, manufacture products at an acceptable cost and with appropriate quality, or successfully market such products with desired margins, we may never achieve profitable operations. The amount of net losses and the time required to reach sustained profitability are highly uncertain. We cannot assure you that we will be able to achieve or sustain profitability. Our commitment of resources to the development of Zenapax and the humanized anti-IL-4 antibody, two humanized antibodies with respect to which we recently obtained development rights, taken together with the continued development of our existing products, will require significant additional funds for development. Our operating expenses may also increase as: - some of our earlier stage potential products move into later stage clinical development - additional potential products are selected as clinical candidates for further development - we invest in additional manufacturing capacity - we defend or prosecute our patents and patent applications, and - we invest in research or acquire additional technologies, product candidates or businesses. In the absence of substantial revenues from new corporate collaborations or patent licensing or humanization agreements, significant royalties on sales of products licensed under our intellectual property rights, product sales or other uncertain sources of revenue, we will incur substantial operating losses. 15 16 OUR REVENUES, EXPENSES AND OPERATING RESULTS WILL LIKELY FLUCTUATE IN FUTURE PERIODS. Our revenues have varied in the past and will likely continue to fluctuate considerably from quarter to quarter and from year to year. As a result, our revenues in any period may not be predictive of revenues in any subsequent period. Our royalty revenues may be unpredictable and may fluctuate since they depend upon: - the seasonality of sales of licensed products - the existence of competing products - the marketing efforts of our licensees - potential reductions in royalties payable to us due to credits for prior payments to us - the timing of royalty reports, some of which are required quarterly and others semi-annually - our method of accounting for royalty revenues from our licensees, and - our ability to successfully defend and enforce our patents. Other revenue may also be unpredictable and may fluctuate due to the timing of payments of non-recurring licensing and signing fees and payments for manufacturing services and achievement of milestones under new and existing collaborative, humanization, and patent licensing agreements. Revenue historically recognized under our prior agreements may not be an indicator of non-royalty revenue from any future collaborations. In December 1999, the Securities and Exchange Commission issued Staff Accounting Bulletin No. 101, "Revenue Recognition in Financial Statements" (SAB 101). We are evaluating the effects, if any, that the adoption of SAB 101 in the second quarter of 2000 may have on the results of our operations or our financial position. We have been advised that the Securities and Exchange Commission intends to provide additional guidance during the second quarter of 2000 with respect to the implementation of SAB 101. It is currently unknown whether such guidance and implementation of SAB 101 will require us to revise our revenue recognition practices or to restate revenues for the first quarter of 2000. In addition, our expenses may be unpredictable and may fluctuate from quarter to quarter due to the timing of expenses, which may include payments owed by us under licensing arrangements. OUR HUMANIZATION PATENTS ARE BEING OPPOSED AND A SUCCESSFUL CHALLENGE COULD LIMIT OUR FUTURE REVENUES. PDL's two humanization patents issued by the European Patent Office (EPO) apply in the United Kingdom, Germany, France, Italy and eight other European countries. The EPO procedures provide for an opposition period in which other parties may submit arguments as to why a patent was incorrectly granted and should be withdrawn or limited. Eighteen notices of opposition to our first European patent were filed during the opposition period for the patent, including oppositions by major pharmaceutical and biotechnology companies. At an oral hearing in March 2000, the 16 17 Opposition Division (OD) of the EPO decided to revoke the broad claims in our first European patent based on formal matters of European patent law, specifically that there had been an impermissible addition of subject matter after the filing of the original European patent application, but did not provide the rationale behind its decision. The decision upheld claims that protect Zenapax. The OD did not otherwise announce a decision on the issue of whether the claims in our patent are inventive in light of the prior art or other issues of patentability. We plan to appeal the OD's decision to the Technical Board of Appeals at the EPO. The Technical Board of Appeals will consider all issues anew. The appeal suspends the decision of the OD during the appeals process, which is likely to take several years. Until our appeal regarding our first European patent is resolved, we may be limited in our ability to collect royalties or to negotiate future licensing or collaborative research and development arrangements based on this and our other humanization patents. Moreover, if our appeal is unsuccessful, our ability to collect royalties on European sales of antibodies humanized by others would depend on the scope and validity of our second European patent, whether the antibodies are manufactured in a country outside of Europe where they are covered by one of our patents, and in that case the terms of our license agreements with respect to that situation. Also, the OD's decision could encourage challenges of our related patents in other jurisdictions, including the U.S. The OD's decision may lead some of our licensees to stop making royalty payments or lead potential licensees not to take a license, which might result in us initiating formal legal actions to enforce our rights under our various humanization patents. In such a situation, a likely defensive strategy to our action would be to challenge our patents in that jurisdiction. During the appeals process with respect to our first European patent, if we were to commence an infringement action to enforce that patent, such an action would likely be stayed until the appeal is decided by the EPO. We have no assurance that we will successfully enforce our rights under our European or related U.S. and Japanese patents. The nine month opposition period for our second European antibody humanization patent ends in May 2000, and we expect that a significant number of notices of opposition will be filed with respect to this patent. We have also been advised that three opposition statements have been filed with the Japanese Patent Office with respect to our humanization patent issued in Japan in late 1998. We intend to vigorously defend the European patents and the Japanese patent in these proceedings; however, we may not prevail in the opposition proceedings or any litigation contesting the validity of these patents. If our appeal with respect to our first European patent is unsuccessful or if the outcome of the other European or Japanese opposition proceedings or any litigation involving our antibody humanization patents were to be unfavorable, our ability to collect royalties on existing licensed products and to license our patents relating to humanized antibodies may be materially harmed. In addition, these proceedings or any other litigation to protect our intellectual property rights or defend against infringement claims by others, could result in substantial costs and diversion of management's time and attention, which could materially harm our business and financial condition. IF WE ARE UNABLE TO PROTECT OUR PATENTS AND PROPRIETARY TECHNOLOGY, WE MAY NOT BE ABLE TO COMPETE SUCCESSFULLY. Our success depends significantly on our ability to obtain and maintain patent protection for our products and technologies, to preserve our trade secrets and to operate without infringing on the proprietary rights of third parties. While we file and prosecute patent applications to protect our 17 18 inventions, our pending patent applications may not result in the issuance of valid patents or our issued patents may not provide competitive advantages. Also, our patent protection may not prevent others from developing competitive products using related or other technology. A number of companies, universities and research institutions have filed patent applications or received patents in the areas of antibodies and other fields relating to our programs. Some of these applications or patents may be competitive with our applications or contain material that could prevent the issuance of patents to us or result in a significant reduction in the scope of our issued patents. The scope, enforceability and effective term of patents issued to companies, universities and research institutions can be highly uncertain and often involve complex legal and factual questions. No consistent policy has emerged regarding the breadth of claims in biotechnology patents, so that even issued patents may later be modified or revoked by the relevant patent authorities or courts. Moreover, the issuance of a patent in one country does not assure the issuance of a patent with similar claims in another country, and claim interpretation and infringement laws vary among countries, so we are unable to predict the extent of any patent protection in different countries. In addition to seeking the protection of patents and licenses, we also rely upon trade secrets, know-how and continuing technological innovation which we seek to protect, in part, by confidentiality agreements with employees, consultants, suppliers and licensees. If these agreements are not honored, we might not have adequate remedies for any breach. Additionally, our trade secrets might otherwise become known or patented by our competitors. WE MAY REQUIRE ADDITIONAL PATENT LICENSES IN ORDER TO MANUFACTURE OR SELL OUR POTENTIAL PRODUCTS. Other companies, universities and research institutions may obtain patents that could limit our ability to use, import, manufacture, market or sell our products or impair our competitive position. As a result, we might be required to obtain licenses from others before we could continue using, importing, manufacturing, marketing, or selling our products. We may not be able to obtain required licenses on terms acceptable to us, if at all. If we do not obtain required licenses, we may encounter significant delays in product development while we redesign potentially infringing products or methods or may not be able to market our products at all. Celltech Chiroscience plc has been granted a patent by the EPO covering humanized antibodies (European Adair Patent), which we have opposed. Celltech has also been issued a corresponding U.S. patent (U.S. Adair Patent) that contains claims that may be considered broader in scope than the European Adair Patent. Recently, we entered into an agreement with Celltech providing each company with the right to obtain nonexclusive licenses for up to three antibody targets under the other company's humanization patents. Nevertheless, if our SMART antibodies were covered by the European or U.S. Adair Patent and if we were to need more than the three licenses under those patents currently available to us under the agreement, we would be required to negotiate additional licenses under those patents or to significantly alter our processes or products. We might not be able to successfully alter our processes or products to avoid conflict with these patents or to obtain the required additional licenses on commercially reasonable terms, if at all. 18 19 In addition, if U.S. Adair Patent or any related patent applications conflict with our U.S. patents or patent applications, we may become involved in proceedings to determine which company was the first to invent the products or processes contained in the conflicting patents. These proceedings could be expensive, last several years and either prevent issuance of additional patents to us relating to humanization of antibodies or result in a significant reduction in the scope or invalidation of our patents. Any limitation would reduce our ability to negotiate or collect royalties or to negotiate future collaborative research and development agreements based on these patents. Lonza Biologics, Inc. has a patent issued in Europe to which we do not have a license (although we have been advised by Roche that it has a license covering Zenapax) that may cover a process that we use to produce our potential products. If our processes were covered by this patent, we might be required to obtain a license under this patent or to significantly alter our processes or products in Europe. We might not be able to successfully alter our processes or products to avoid conflict with this patent or to obtain a license on commercially reasonable terms. We do not have a license to an issued U.S. patent assigned to Stanford University and Columbia University, which may cover a process we use to produce our potential products. We have been advised that an exclusive license has been previously granted to a third party under this patent. If our processes were covered by this patent, we might be required to obtain a license or to significantly alter our processes or products in the U.S. We might not be able to successfully alter our processes or products to avoid conflict with this patent or to obtain a license on acceptable terms. Moreover, if we do not obtain the required licenses, any alteration of processes or products to avoid conflict with a competitive patent could result in a significant delay in our achieving regulatory approval for the products affected by these alterations. IF WE CANNOT SUCCESSFULLY COMPLETE OUR CLINICAL TRIALS, WE WILL BE UNABLE TO OBTAIN REGULATORY APPROVALS REQUIRED TO MARKET OUR PRODUCTS. To obtain regulatory approval for the commercial sale of any of our potential products or to promote these products for expanded indications, we must demonstrate through preclinical testing and clinical trials that each product is safe and effective for use in indications for which approval is requested. We have conducted only a limited number of clinical trials to date. We may not be able to successfully commence and complete all of our planned clinical trials without significant additional resources and expertise. Our potential inability to commence or continue clinical trials, to complete the clinical trials on a timely basis or to demonstrate the safety and efficacy of our potential products, further adds to the uncertainty of regulatory approval for our potential products. Larger and later stage clinical trials may not produce the same results as early stage trials. Many companies in the pharmaceutical and biotechnology industries, including PDL, have suffered significant setbacks in clinical trials, including advanced clinical trials, even after promising results had been obtained in earlier trials. Research, preclinical testing and clinical trials may take many years to complete and the time required can vary depending on the indication being addressed and the nature of the product. We may at times elect to use aggressive clinical strategies in order to advance potential products through clinical development as rapidly as possible. For example, we may commence clinical trials without conducting preclinical animal testing, where an appropriate animal testing model does not exist, or we may conduct later stage trials based on limited early stage data. As a result, we anticipate that 19 20 only some of our potential products may show safety and efficacy in clinical trials and some may encounter difficulties or delays during clinical development. For example, we have entered the SMART M195 Antibody into a Phase III clinical trial in acute myelogenous leukemia with a clinical regimen that has not been tested previously with this antibody. Results from our prior Phase II and Phase II/III studies showed only a limited number of complete and partial remissions. In addition, we initiated a Phase III study without a meeting with the FDA or European regulatory authorities to discuss the protocol and its adequacy to support approval of the SMART M195 Antibody. We believe that our Phase III program is reasonable in view of the nature and severity of the disease. We cannot assure you that the study will be successful or that the FDA or European regulatory authorities will agree that the study will be adequate to obtain regulatory approval, even if the study is successful. In addition, the protocol for our Phase III trial includes an interim review by an independent data safety monitoring board. It is possible that the trial could be terminated upon such a review if the interim data do not show a sufficient probability of the trial being successful or if specified safety criteria are not met. As a second example, the FDA recently placed a clinical hold on clinical trials of our SMART Anti-CD3 Antibody for kidney transplant indications due to their belief that we have not supplied adequate data from our prior trials to support our proposed dosage modifications to the Phase II study for prevention of kidney transplant rejection. Although our clinical trials of this antibody in other indications, such as psoriasis, are not affected by this hold, our clinical studies of this potential product for prevention or treatment of kidney transplant rejection will be delayed in the U.S. until we supply sufficient data to the FDA to justify our desired clinical study designs. Also, we may be required to further modify our clinical study designs to comply with FDA requirements and possibly to conduct additional Phase I trials before proceeding with Phase II trials. Accordingly, there can be no assurance that we will be able, or will choose, to proceed with development of this antibody for either or both of the transplant indications. WE MAY BE UNABLE TO ENROLL SUFFICIENT PATIENTS TO COMPLETE OUR CLINICAL TRIALS. The rate of completion of our clinical trials, and those of our collaborators, is significantly dependent upon the rate of patient enrollment. Patient enrollment is a function of many factors, including: - the size of the patient population - perceived risks and benefits of the drug under study - availability of competing therapies - availability of clinical trial sites - design of the protocol - proximity of and access by patients to clinical sites - patient referral practices of physicians - eligibility criteria for the study in question, and 20 21 - efforts of the sponsor of and clinical sites involved in the trial to facilitate timely enrollment. We may have difficulty obtaining sufficient patient enrollment or clinician support to conduct our clinical trials as planned, and we may have to expend substantial additional funds to obtain access to resources or delay or modify our plans significantly. These considerations may lead us to consider the termination of ongoing clinical trials or development of a product for a particular indication. WE MAY BE UNABLE TO OBTAIN OR MAINTAIN REGULATORY APPROVAL FOR OUR PRODUCTS. The manufacturing, testing and marketing of our products are subject to regulation by numerous governmental authorities in the U.S. and other countries. In the U.S., pharmaceutical products are subject to rigorous FDA regulation. Additionally, other federal, state and local regulations govern the manufacture, testing, clinical and nonclinical studies to assess safety and efficacy, approval, advertising and promotion of pharmaceutical products. The process of obtaining approval for a new pharmaceutical product or for additional therapeutic indications within this regulatory framework requires a number of years and the expenditure of substantial resources. Companies in the pharmaceutical and biotechnology industries, including us, have suffered significant setbacks in various stages of clinical trials, even in advanced clinical trials after promising results had been obtained in earlier trials. In addition to the requirement for FDA approval of each pharmaceutical product, each pharmaceutical product manufacturing facility must be registered with, and approved by, the FDA. The manufacturing and quality control procedures must conform to rigorous guidelines in order to receive FDA approval. Pharmaceutical product manufacturing establishments are subject to inspections by the FDA and local authorities as well as inspections by authorities of other countries. To supply pharmaceutical products for use in the U.S., foreign manufacturing establishments must comply with these FDA approved guidelines. These foreign manufacturing establishments are subject to periodic inspection by the FDA or by corresponding regulatory agencies in these countries under reciprocal agreements with the FDA. Moreover, pharmaceutical product manufacturing facilities may also be regulated by state, local and other authorities. For the marketing of pharmaceutical products outside the U.S., we and our collaborative partners are subject to foreign regulatory requirements and, if the particular product is manufactured in the U.S., FDA and other U.S. export provisions. Requirements relating to the manufacturing, conduct of clinical trials, product licensing, promotion, pricing and reimbursement vary widely in different countries. Difficulties or unanticipated costs or price controls may be encountered by us or our licensees or marketing partners in our respective efforts to secure necessary governmental approvals. This could delay or prevent us or our licensees or our marketing partners from marketing potential pharmaceutical products. Both before and after approval is obtained, a pharmaceutical product, its manufacturer and the holder of the Biologics License Application (BLA) for the pharmaceutical product are subject to comprehensive regulatory oversight. The FDA may deny a BLA if applicable regulatory criteria are not satisfied. Moreover, even if regulatory approval is granted, such approval may be subject to limitations on the indicated uses for which the pharmaceutical product may be marketed. Further, marketing approvals may be withdrawn if compliance with regulatory standards is not maintained or if problems with the pharmaceutical product occur following approval. In addition, under a BLA, 21 22 the manufacturer continues to be subject to facility inspection and the applicant must assume responsibility for compliance with applicable pharmaceutical product and establishment standards. Violations of regulatory requirements at any stage may result in various adverse consequences, which may include, among other adverse actions, withdrawal of the previously approved pharmaceutical product or marketing approvals and/or the imposition of criminal penalties against the manufacturer and/or BLA holder. OUR REVENUES FROM LICENSED TECHNOLOGIES DEPEND ON THE EFFORTS AND SUCCESSES OF OUR LICENSEES. In those instances where we have licensed rights to our technologies, the product development and marketing efforts and successes of our licensees will determine the amount and timing of royalties we may receive, if any. We have no assurance that any licensee will successfully complete the product development, regulatory and marketing efforts required to sell products. The success of products sold by licensees, such as Roche, will be affected by competitive products, including potential competing therapies that are marketed by the licensee or others. IF OUR COLLABORATIONS ARE NOT SUCCESSFUL, WE MAY NOT BE ABLE TO EFFECTIVELY DEVELOP AND MARKET SOME OF OUR PRODUCTS. We have collaborative agreements with several pharmaceutical and other companies to develop, manufacture and market Zenapax and some of our potential products. In some cases, we are relying on our collaborative partners to manufacture such products, to conduct clinical trials, to compile and analyze the data received from these trials, to obtain regulatory approvals and, if approved, to market these licensed products. As a result, we may have little or no control over the manufacturing, development and marketing of these potential products and little or no opportunity to review clinical data prior to or following public announcement. Our collaborative agreements can generally be terminated by our partners on short notice. A collaborator may terminate its agreement with us or separately pursue alternative products, therapeutic approaches or technologies as a means of developing treatments for the diseases targeted by us or our collaborative effort. Even if a collaborator continues its contributions to the arrangement, it may nevertheless determine not to actively pursue the development or commercialization of any resulting products. In these circumstances, our ability to pursue potential products could be severely limited. Continued funding and participation by collaborative partners will depend on the timely achievement of our research and development objectives, the retention of key personnel performing work under those agreements and on each collaborative partner's own financial, competitive, marketing and strategic considerations. Such considerations include: - the commitment of management of the collaborative partners to the continued development of the licensed products or technology - the relationships among the individuals responsible for the implementation and maintenance of the collaborative efforts, and - the relative advantages of alternative products or technology being marketed or developed by the collaborators or by others, including their relative patent and 22 23 proprietary technology positions, and their ability to manufacture potential products successfully. Our ability to enter into new collaborations and the willingness of our existing collaborators to continue development of our potential products depends upon, among other things, our patent position with respect to such products. If we are unable to successfully maintain our patents we may be unable to collect royalties on existing licensed products or enter into additional collaborations and agreements. OUR LACK OF EXPERIENCE IN SALES, MARKETING AND DISTRIBUTION MAY HAMPER MARKET INTRODUCTION AND ACCEPTANCE OF OUR PRODUCTS. We intend to market and sell a number of our products either directly or through sales and marketing partnership arrangements with collaborative partners. To market products directly, we must either establish a marketing group and direct sales force or obtain the assistance of another company. We may not be able to establish marketing, sales and distribution capabilities or succeed in gaining market acceptance for our products. If we were to enter into co-promotion or other marketing arrangements with pharmaceutical or biotechnology companies, our revenues would be subject to the payment provisions of these arrangements and dependent on the efforts of third parties. MANUFACTURING DIFFICULTIES COULD DELAY COMMERCIALIZATION OF OUR PRODUCTS. Of the products that we currently have in clinical development, Roche is responsible for manufacturing Zenapax, SmithKline Beecham is responsible for manufacturing the humanized anti-IL-4 antibody and Scil is responsible for manufacturing the SMART Anti-L-Selectin Antibody. We are responsible for manufacturing our other products for our own development. We intend to continue to manufacture potential products for use in preclinical and clinical trials using our manufacturing facility in accordance with standard procedures that comply with appropriate regulatory standards. The manufacture of sufficient quantities of antibody products that comply with these standards is an expensive, time-consuming and complex process and is subject to a number of risks that could result in delays. For example, we and our collaborative partners have experienced some manufacturing difficulties. Product supply interruptions could significantly delay clinical development of our potential products, reduce third party or clinical researcher interest and support of proposed clinical trials, and possibly delay commercialization and sales of these products. Manufacturing difficulties can even interrupt the supply of marketed products, thereby reducing revenues and risking loss of market share. For example, Roche has received a warning letter from the FDA regarding deficiencies in the manufacture of various products. Although the letter primarily related to products other than Zenapax, at least two deviations in the manufacture of Zenapax were noted. If Roche were not able to correct these and any other deficiencies in the manufacture of Zenapax in a timely manner, Zenapax supplies could be interrupted, which could cause a delay or termination of our clinical trials of Zenapax in autoimmune disease and could force Roche to withdraw Zenapax from the market temporarily or permanently, resulting in loss of revenue to us. These occurrences could materially impair our competitive position. We do not have experience in manufacturing commercial quantities of our potential products, nor do we currently have sufficient capacity to manufacture all of our potential products on a commercial scale. In order to obtain regulatory approvals and to create capacity to produce our products for commercial sale at an acceptable cost, we will need to improve and expand our existing 23 24 manufacturing capabilities. We are reviewing plans to expand our manufacturing capacity, including possible acquisition and conversion of an existing building into a manufacturing plant. If we implement these plans we will incur substantial costs. Any construction delays could impair our ability to produce adequate supplies of our potential products for clinical use or commercial sale on a timely basis. Further, we may be unable to improve and expand our manufacturing capability sufficiently to obtain necessary regulatory approvals and to produce adequate commercial supplies of our potential products on a timely basis. Failure to do so could delay commercialization of these products and could impair our competitive position. MANUFACTURING CHANGES MAY RESULT IN DELAYS IN OBTAINING REGULATORY APPROVAL OR MARKETING FOR OUR PRODUCTS. Manufacturing of antibodies for use as therapeutics in compliance with regulatory requirements is complex, time-consuming and expensive. If we make changes in the manufacturing process, we may be required to demonstrate to the FDA and corresponding foreign authorities that the changes have not caused the resulting drug material to differ significantly from the drug material previously produced. This is particularly important if we want to rely on results of prior preclinical studies and clinical trials performed using the previously produced drug material. Depending upon the type and degree of differences between the newer and older drug material, we may be required to conduct additional animal studies or human clinical trials to demonstrate that the newly produced drug material is sufficiently similar to the previously produced drug material. We have made manufacturing changes and are likely to make additional manufacturing changes for the production of our products currently in clinical development, such as the SMART M195 and SMART Anti-CD3 Antibodies. These manufacturing changes could result in delays in development or regulatory approvals or in reduction or interruption of commercial sales and could impair our competitive position. OUR BUSINESS MAY BE HARMED IF WE CANNOT OBTAIN SUFFICIENT QUANTITIES OF RAW MATERIALS. We depend on outside vendors for the supply of raw materials used to produce our product candidates. Once a supplier's materials have been selected for use in our manufacturing process, the supplier in effect becomes a sole or limited source of that raw material due to regulatory compliance procedures. If the third party suppliers were to cease production or otherwise fail to supply us with quality raw materials and we were unable to contract on acceptable terms for these services with alternative suppliers, our ability to produce our products and to conduct preclinical testing and clinical trials of product candidates would be adversely affected. This could impair our competitive position. OUR REVENUE MAY BE ADVERSELY AFFECTED BY COMPETITION AND RAPID TECHNOLOGICAL CHANGE. We are aware that potential competitors have developed and are developing human and humanized antibodies or other compounds for treating autoimmune diseases, transplantation, inflammatory conditions and cancers. In addition, a number of academic and commercial organizations are actively pursuing similar technologies, and several companies have developed or may develop technologies that may compete with our SMART antibody technology. Competitors may succeed in more rapidly developing and marketing technologies and products that are more effective than our products or that would render our products or technology obsolete or noncompetitive. Our collaborative partners may also independently develop products that are competitive with products 24 25 that we have licensed to them. This could reduce our revenues under our agreements with these partners. Any product that we or our collaborative partners succeed in developing and for which regulatory approval is obtained must then compete for market acceptance and market share. The relative speed with which we and our collaborative partners can develop products, complete the clinical testing and approval processes, and supply commercial quantities of the products to the market compared to competitive companies will affect market success. For example, Novartis, which has a significant marketing and sales force directed to the transplantation market, has received approval to market Simulect(R), a product competitive with Zenapax, in the U.S. and Europe. Since Novartis launched Simulect in the European Union earlier than Roche, Zenapax may have a smaller market share than Simulect and other available products. Other competitive factors include: - the capabilities of our collaborative partners - product efficacy and safety - timing and scope of regulatory approval - product availability, marketing and sales capabilities - reimbursement coverage - the amount of clinical benefit of our products relative to their cost - method of and frequency of administration of our products - price of our products, and - patent protection of our products. IF WE DO NOT ATTRACT AND RETAIN KEY EMPLOYEES, OUR BUSINESS COULD BE IMPAIRED. To be successful, we will have to retain our qualified clinical, manufacturing, scientific and management personnel. Because we are located in a high technology area, we face competition for personnel from other companies, academic institutions, government entities and other organizations. We are currently conducting a search for a chief financial officer and a vice president of marketing, as well as other senior management personnel. If we are unsuccessful in filling these positions or retaining qualified personnel, our business could be impaired. WE MAY BE SUBJECT TO PRODUCT LIABILITY CLAIMS, AND OUR INSURANCE COVERAGE MAY NOT BE ADEQUATE TO COVER THESE CLAIMS. We face an inherent business risk of exposure to product liability claims in the event that the use of products during research and development efforts or after commercialization results in adverse effects. This risk will exist even with respect to any products that receive regulatory approval for commercial sale. While we have obtained liability insurance for our products, it may not be 25 26 sufficient to satisfy any liability that may arise. Also, adequate insurance coverage may not be available in the future at acceptable cost, if at all. WE MAY REQUIRE ADDITIONAL FUNDS THAT MAY BE DIFFICULT TO OBTAIN IN ORDER TO CONTINUE OUR BUSINESS ACTIVITIES AS PLANNED. Our operations to date have consumed substantial amounts of cash. We will be required to spend substantial funds in conducting clinical trials, to expand our marketing capabilities and efforts, to expand existing research and development programs, to develop and expand our development and manufacturing capabilities and to defend or prosecute our patents and patent applications. In order to develop and commercialize our products, we may need to raise substantial additional funds through equity or debt financings, collaborative arrangements, the use of sponsored research efforts or other means. Additional financing may not be available on acceptable terms, if at all, and may only be available on terms dilutive to existing stockholders or that would increase the amount of our indebtedness. Our inability to secure adequate funds on a timely basis could result in the delay or cancellation of programs that we might otherwise pursue. WE MAY INCUR SIGNIFICANT COSTS IN ORDER TO COMPLY WITH ENVIRONMENTAL REGULATIONS OR TO DEFEND CLAIMS ARISING FROM ACCIDENTS INVOLVING THE USE OF HAZARDOUS MATERIALS. We are subject to federal, state and local laws and regulations governing the use, discharge, handling and disposal of materials and wastes used in our operations. As a result, we may be required to incur significant costs to comply with these laws and regulations. We cannot eliminate the risk of accidental contamination or injury from these materials. In the event of such an accident, we could be held liable for any resulting damages and incur liabilities which exceed our resources. In addition, we cannot predict the extent of the adverse effect on our business or the financial and other costs that might result from any new government requirements arising out of future legislative, administrative or judicial actions. CHANGES IN THE U.S. AND INTERNATIONAL HEALTH CARE INDUSTRY COULD ADVERSELY AFFECT OUR REVENUES. The U.S. and international health care industry is subject to changing political, economic and regulatory influences that may significantly affect the purchasing practices and pricing of pharmaceuticals. Cost containment measures, whether instituted by health care providers or imposed by government health administration regulators or new regulations, could result in greater selectivity in the purchase of drugs. As a result, third-party payors may challenge the price and cost effectiveness of our products. In addition, in many major markets outside the U.S., pricing approval is required before sales can commence. As a result, significant uncertainty exists as to the reimbursement status of approved health care products. We may not be able to obtain or maintain our desired price for our products. Our products may not be considered cost effective relative to alternative therapies. As a result, adequate third-party reimbursement may not be available to enable us to maintain prices sufficient to realize an appropriate return on our investment in product development. Also, the trend towards managed health care in the U.S. and the concurrent growth of organizations such as health maintenance organizations, as well as legislative proposals to reform health care or reduce government insurance programs, may all result in lower prices, reduced reimbursement levels and diminished markets for 26 27 our products. These factors will also affect the products that are marketed by our collaborative partners. AS A RESULT OF OUR SALE OF THE NOTES, WE WILL HAVE A SIGNIFICANT AMOUNT OF DEBT AND MAY HAVE INSUFFICIENT CASH TO SATISFY OUR DEBT SERVICE OBLIGATIONS. IN ADDITION, THE AMOUNT OF OUR DEBT COULD IMPEDE OUR OPERATIONS AND FLEXIBILITY. As a result of our sale of the notes, we have a significant amount of debt and debt service obligations. If we are unable to generate sufficient cash flow or otherwise obtain funds necessary to make required payments on the notes, including from cash and cash equivalents on hand, we will be in default under the terms of the indenture which could, in turn, cause defaults under our other existing and future debt obligations. Even if we are able to meet our debt service obligations, the amount of debt we have could adversely affect us in a number of ways, including by: - limiting our ability to obtain any necessary financing in the future for working capital, capital expenditures, debt service requirements or other purposes - limiting our flexibility in planning for, or reacting to, changes in our business - placing us at a competitive disadvantage relative to our competitors who have lower levels of debt - making us more vulnerable to a downturn in our business or the economy generally, and - requiring us to use a substantial portion of our cash to pay principal and interest on our debt, instead of applying those funds to other purposes such as working capital and capital expenditures. WE MAY BE UNABLE TO REPURCHASE THE NOTES UPON THE OCCURRENCE OF A CHANGE IN CONTROL. Upon the occurrence of a Change in Control of PDL, we will be required to offer to repurchase all outstanding notes. Although the Indenture allows us, subject to satisfaction of certain conditions, to repurchase the notes using shares of our common stock, if a Change in Control were to occur, our ability to repurchase the notes with cash will depend on the availability of sufficient funds and compliance with the terms of any debt ranking senior to the notes. Our failure to repurchase tendered notes upon a Change in Control would constitute an event of default under the Indenture, which could result in the acceleration of the maturity of the notes and all of our other outstanding debt. These repurchase requirements may also delay or make it harder for others to obtain control of us. CLAIMS BY HOLDERS OF THE NOTES WILL BE SUBORDINATED TO CLAIMS BY HOLDERS OF OUR SENIOR DEBT. The notes rank behind all of our Senior Debt. The notes are effectively subordinated in right of payment to all indebtedness and other liabilities of our subsidiaries. As a result, if we declare bankruptcy, liquidate, reorganize, dissolve or otherwise wind up our affairs or are subjected to 27 28 similar proceedings, we must repay all Senior Debt before we will be able to make any payments on the notes. Likewise, upon a default in payment with respect to any of our debt or an event of default with respect to this debt resulting in its acceleration, our assets will be available to pay the amounts due on the notes only after all Senior Debt has been paid in full. The Indenture does not prohibit us from incurring additional Senior Debt, other debt or other liabilities or our subsidiaries from incurring any indebtedness. Our ability to pay our obligations on the notes could be adversely affected if we incur more debt. As of December 31, 1999, one of our subsidiaries had outstanding approximately $10.1 million of indebtedness to which the notes are effectively subordinated. See "Description of the Notes--Subordination." YOU CANNOT BE SURE THAT AN ACTIVE TRADING MARKET WILL DEVELOP FOR THE NOTES. While the outstanding notes are eligible for trading in the PORTAL Market, there is no public market for the notes. The Initial Purchasers, as that term is defined in this prospectus, informed us that they intend to make a market in the notes, but they may cease their market-making at any time. We do not intend to apply for a listing of any of the notes on any securities exchange. We do not know if an active public market has developed or will develop for the notes or, if developed, will continue. If an active market is not developed or maintained, the market price and the liquidity of the notes may be adversely affected. In addition, the liquidity and the market price of the notes may be adversely affected by changes in the overall market for convertible securities and by changes in our financial performance or prospects, or in the prospects for companies in our industry. As a result, you cannot be sure that an active trading market will develop for these notes. OUR COMMON STOCK PRICE IS VOLATILE AND AN INVESTMENT IN OUR COMPANY COULD DECLINE IN VALUE. Market prices for securities of biotechnology companies (including PDL) have been highly volatile so that investment in our securities involves substantial risk. Additionally, the stock market from time to time has experienced significant price and volume fluctuations that may be unrelated to the operating performance of particular companies. The following are some of the factors that may have a significant effect on the market price of our common stock: - developments or disputes as to patent or other proprietary rights - disappointing sales of approved products - approval or introduction of competing products and technologies - results of clinical trials - failures or unexpected delays in obtaining regulatory approvals or FDA advisory panel recommendations - delays in manufacturing or clinical trial plans - fluctuations in our operating results 28 29 - disputes or disagreements with collaborative partners - market reaction to announcements by other biotechnology or pharmaceutical companies - announcements of technological innovations or new commercial therapeutic products by us or our competitors - initiation, termination or modification of agreements with our collaborative partners - loss of key personnel - litigation or the threat of litigation - public concern as to the safety of drugs developed by us - sales of our common stock held by collaborative partners or insiders - comments and expectations of results made by securities analysts, and - general market conditions. If any of these factors causes us to fail to meet the expectations of securities analysts or investors, or if adverse conditions prevail or are perceived to prevail with respect to our business, the price of the common stock would likely drop significantly. A significant drop in the price of a company's common stock often leads to the filing of securities class action litigation against the company. This type of litigation against us could result in substantial costs and a diversion of management's attention and resources. SUBSTANTIAL SALES OF OUR COMMON STOCK COULD CAUSE OUR STOCK PRICE AND THE PRICE OF THE NOTES TO FALL. If our stockholders sell substantial amounts of our common stock, including shares issued upon the exercise of outstanding options, the market prices of the notes and our common stock could fall. Such sales also might make it more difficult for us to sell equity or equity-related securities in the future at a time and price that we deem appropriate. Substantially all of our outstanding shares of common stock can be sold at any time without limitation. 29 30 USE OF PROCEEDS We will not receive any proceeds from the sale of the notes or the shares of common stock issuable on conversion of the notes. See "Selling Security Holders." PRICE RANGE OF COMMON STOCK Our common stock trades on The Nasdaq National Market under the symbol "PDLI." The following table sets forth for the periods indicated the high and low closing bid prices for our common stock as quoted on The Nasdaq National Market. On April 25, 2000, the closing bid price quoted on The Nasdaq National Market for the common stock was $78.875 per share. On March 31, 2000, there were approximately 127 holders of record of our common stock. Because many of these shares are held by brokers and other institutions on behalf of stockholders, we are unable to estimate the total number of stockholders represented by these record holders. DIVIDEND POLICY We have never declared or paid cash dividends on our capital stock. We currently intend to retain all available funds and any future earnings for use in the operation and expansion of our business and do not anticipate paying any cash dividends in the foreseeable future. Payment of future dividends, if any, will be at the discretion of our board of directors after taking into account various factors, including our financial condition, operating results and current and anticipated cash needs. 30
HIGH LOW ---- --- 1998 First Quarter ............................... $ 46 1/4 $ 34 5/8 Second Quarter .............................. 39 1/2 20 1/8 Third Quarter ............................... 26 1/4 16 3/4 Fourth Quarter .............................. 27 1/4 16 1/2 1999 First Quarter ............................... $ 26 1/2 $ 13 1/4 Second Quarter .............................. 22 14 3/8 Third Quarter ............................... 36 1/8 22 1/8 Fourth Quarter .............................. 72 5/8 32 1/4 2000 First Quarter ............................... $ 327 1/4 $ 59 7/16 Second Quarter (through April 25, 2000) ..... 110 13/16 59 5/16 31 DESCRIPTION OF THE NOTES The 5.50% Convertible Subordinated Notes due February 15, 2007 were issued under an indenture (the Indenture) between us and Chase Manhattan Bank and Trust Company, National Association, as trustee. The Indenture and the notes are governed by New York law. Because this section is a summary, it does not describe every aspect of the notes. This summary is subject to and qualified in its entirety by reference to all the provisions of the Indenture, including definitions of certain terms used in the Indenture. For example, we use capitalized words to signify defined terms that have been given special meaning in the Indenture. We describe the meaning for only the more important terms. Wherever we refer to particular defined terms, those terms are incorporated herein by reference. In this section, references to "PDL", "we" or "us" refer solely to PDL and not to any of our subsidiaries. GENERAL The notes are general, unsecured obligations of PDL. The notes are subordinated, which means that they rank behind certain of our other indebtedness as described below. The aggregate principal amount of the notes is $150,000,000. The notes bear interest at 5.50% per year from February 15, 2000. We will pay interest twice a year, on each February 15 and August 15 (each, an Interest Payment Date), beginning August 15, 2000, until the principal is paid or made available for payment or the notes have been converted. Interest will be paid to the person in whose name the note is registered at the close of business on the preceding February 1 or August 1, as the case may be (each, a Regular Record Date). Interest payable per $1,000 principal amount of notes for the period from February 15, 2000 to August 15, 2000, will be $27.50. Interest will be calculated on the basis of a 360-day year consisting of twelve 30-day months. You may convert the notes into shares of our common stock at any time before the close of business on February 15, 2007 unless the notes have been previously redeemed or repurchased. The initial conversion rate is 6.6225 shares per each $1,000 principal amount of notes. This is equivalent to a conversion price of approximately $151.00 per share. The conversion rate may be adjusted as described below. We may redeem the notes at our option at any time on or after February 15, 2003, in whole or in part, at the redemption prices set forth below under "Optional Redemption", plus accrued and unpaid interest to the redemption date. If there is a Change in Control (as defined below), you may have the right to require us to repurchase your notes as described below under "Repurchase at Option of Holders Upon a Change in Control." FORM, DENOMINATION, TRANSFER, EXCHANGE AND BOOK-ENTRY PROCEDURES The notes will be issued: - only in fully registered form - without interest coupons, and - in denominations of $1,000 and integral multiples thereof. 31 32 Principal of, premium, if any, and interest (and Liquidated Damages (as defined below), if any) on the notes will be payable, and the notes may be presented for registration or exchange, at the office or agency we maintain for such purpose in the Borough of Manhattan, The City of New York. Until we designate otherwise, our office or agency will be the trustee's corporate trust office now located in the Borough of Manhattan, The City of New York. The notes are currently evidenced by one or more global notes that have been deposited with the trustee as custodian for DTC and registered in the name of Cede & Co. (Cede), as nominee of DTC. Except as set forth below, record ownership of the global note may be transferred, in whole or in part, only to another nominee of DTC or to a successor of DTC or its nominee. The global note will not be registered in the name of any person, or exchanged for notes that are registered in the name of any person, other than DTC or its nominee unless either of the following occurs: - DTC has notified us that it is unwilling or unable to continue as depositary for the global note or has ceased to be a clearing agency registered as such under the Securities Exchange Act of 1934, as amended (the Exchange Act), or announces an intention permanently to cease business or does in fact do so, or - an Event of Default (as defined below) with respect to the notes represented by the global note has occurred and is continuing. In those circumstances, DTC will determine in whose names any securities issued in exchange for the global note will be registered. DTC or its nominee is considered the sole owner and holder of the global note for all purposes, and as a result: - you cannot receive notes registered in your name if they are represented by the global note - you cannot receive certificated (physical) notes in exchange for your beneficial interest in the global notes - you will not be considered to be the owner or holder of the global note or any note it represents for any purpose, and - all payments on the global note will be made to DTC or its nominee. The laws of some jurisdictions require that certain kinds of purchasers (for example, certain insurance companies) can only own securities in definitive (certificated) form. These laws may limit your ability to transfer your beneficial interests in the global note to these types of purchasers. Only institutions (such as a securities broker or dealer) that have accounts with DTC or its nominee (called "participants") and persons that may hold beneficial interests through participants can own a beneficial interest in the global note. The only place where the ownership of beneficial interests in the global note will appear and the only way the transfer of those interests can be made is on the 32 33 records kept by DTC (for its participants' interests) and the records kept by those participants (for interests of persons participants hold on their behalf). Secondary trading in bonds and notes of corporate issuers is generally settled in clearinghouse (that is, next-day) funds. In contrast, beneficial interests in a global note usually trade in DTC's same-day funds settlement system, and settle in immediately available funds. We make no representations as to the effect that settlement in immediately available funds will have on trading activity in those beneficial interests. We will make cash payments of interest on, and principal of, and the redemption or repurchase price of, the global note, as well as any payment of Liquidated Damages, to Cede, the nominee for DTC, as the registered owner of the global note. We will make these payments by wire transfer of immediately available funds on each payment date. We have been informed that, with respect to any cash payment of interest on, principal of, or the redemption or repurchase price of, the global note, as well as any payment of Liquidated Damages, DTC's practice is to credit participants' accounts on the payment date with payments in amounts proportionate to their respective beneficial interests in the notes represented by the global note as shown on DTC's records, unless DTC has reason to believe that it will not receive payment on that payment date. Payments by participants to owners of beneficial interests in notes represented by the global note held through participants will be the responsibility of those participants, as is now the case with securities held for the accounts of customers registered in "street name." We will send any redemption notices to the trustee. If fewer than all of the notes are being redeemed, the particular ratio to be redeemed will be selected by the trustee by a method that the trustee deems to be fair and appropriate. We understand that if less than all of a global note is being redeemed, DTC's current practice is to determine by lot the amount of the holdings of each participant in the global note to be redeemed. We also understand that neither DTC nor Cede will consent or vote with respect to the notes. We have been advised that under its usual procedures, DTC will mail an "omnibus proxy" to us as soon as possible after the record date. The omnibus proxy assigns Cede's consenting or voting rights to those participants to whose accounts the notes are credited on the record date identified in a listing attached to the omnibus proxy. Because DTC can only act on behalf of participants, who in turn act on behalf of indirect participants, the ability of a person having a beneficial interest in the principal amount represented by the global note to pledge the interest to persons or entities that do not participate in the DTC book entry system, or otherwise take actions in respect of that interest, may be affected by the lack of a physical certificate evidencing its interest. DTC has advised us that it will take any action permitted to be taken by a holder of notes (including the presentation of notes for exchange) only at the direction of one or more participants to whose account with DTC interests in the global note are credited and only in respect of such portion of the principal amount of the notes represented by the global note as to which such participant has, or participants have, given such direction. DTC has also advised us as follows: DTC is a limited purpose trust company organized under the laws of the State of New York, a member of the Federal Reserve System, a "clearing corporation" 33 34 within the meaning of the Uniform Commercial Code, as amended, and a "clearing agency" registered pursuant to the provisions of Section 17A of the Exchange Act. DTC was created to hold securities for its participants and to facilitate the clearance and settlement of securities transactions between participants through electronic book-entry changes in accounts of its participants. Participants include securities brokers and dealers, banks, trust companies and clearing corporations and may include certain other organizations. Certain of such participants (or their representatives), together with other entities, own DTC. Indirect access to the DTC system is available to other entities such as banks, brokers, dealers and trust companies that clear through or maintain a custodial relationship with a participant, either directly or indirectly. DTC's policies and procedures, which may change periodically, will apply to payments, transfers, exchanges and other matters relating to beneficial interests in the global note. The trustee and we have no responsibility or liability for any aspect of DTC's or any participant's records relating to beneficial interests in the global note, including for payments made on the global note, and we and the trustee are not responsible for maintaining, supervising or reviewing any of those records. CONVERSION RIGHTS You may, at your option, convert any portion of the principal amount of a note that is an integral multiple of $1,000 into shares of our common stock at any time prior to the close of business on the maturity date; provided, however, that if a note is called for redemption or repurchase, you may convert such note at any time before the close of business on the date fixed for redemption or repurchase, as the case may be, unless we default in making the payment due upon redemption or repurchase. In either case, the conversion rate is equal to 6.6225 shares per $1,000 principal amount of notes, which is equivalent to a conversion price of approximately $151.00 per share. The conversion rate is subject to adjustment as described below. The holder of a note can convert the note by delivering the note at the trustee's corporate trust office, accompanied by a duly signed and completed notice of conversion, a copy of which may be obtained from the trustee. In the case of a global note, DTC will effect the conversion upon notice from the holder of a beneficial interest in the global note in accordance with DTC's rules and procedures. The conversion date will be the date on which the note and the duly signed and completed notice of conversion are so delivered to the trustee. As promptly as practicable on or after the conversion date, we will issue and deliver to the trustee a certificate or certificates for the number of full shares of common stock issuable upon conversion, together with payment in lieu of any fraction of a share, and the trustee shall deliver the certificate(s) to the conversion agent for delivery to the holder of the note being converted. The shares of common stock issuable upon conversion of the notes will be fully paid and nonassessable and will also rank equally with other shares of our common stock outstanding from time to time. If you surrender a note for conversion on a date that is not an Interest Payment Date, you will not be entitled to receive any interest for the period from the preceding Interest Payment Date to the date of conversion, except as described below. However, if you are a holder of a note on a Regular Record Date, including a note that is subsequently surrendered for conversion after the Regular Record Date, you will receive the interest payable on such note on the next Interest Payment Date. To correct for this resulting overpayment of interest, we will require that any note surrendered for conversion during the period from the close of business on a Regular Record Date to the opening of business on the next Interest Payment Date be accompanied by payment of an amount equal to the interest payable on such Interest Payment Date on the principal amount of notes being surrendered for 34 35 conversion. However, you will not be required to make that payment if you are converting a note, or a portion of a note, that we have called for redemption, or that you are entitled to require us to repurchase from you, if your conversion right would terminate because of the redemption or repurchase between the Regular Record Date and the close of business on the next Interest Payment Date. If we distribute rights or warrants (other than those referred to in paragraph (2) below) pro rata to holders of common stock, so long as any such rights or warrants have not expired or been redeemed by us, the holder of any note surrendered for conversion will be entitled to receive upon such conversion, in addition to the shares of common stock issuable upon such conversion (the Conversion Shares), a number of rights or warrants to be determined as follows: - if such conversion occurs on or prior to the date for the distribution to the holders of rights or warrants of separate certificates evidencing such rights or warrants (the Distribution Date), the same number of rights or warrants to which a holder of a number of shares of common stock equal to the number of Conversion Shares is entitled at the time of such conversion in accordance with the terms and provisions of, and applicable to, the rights or warrants, and - if such conversion occurs after such Distribution Date, the same number of rights or warrants to which a holder of the number of shares of common stock into which such note was convertible immediately prior to such Distribution Date would have been entitled on such Distribution Date in accordance with the terms and provisions of, and applicable to, the rights or warrants. No other payment or adjustment for interest, or for any dividends on our common stock, will be made upon conversion. If you receive common stock upon conversion of a note, you will not be entitled to receive any dividends payable to holders of common stock as of any record date before the close of business on the conversion date. We will not issue fractional shares upon conversion of notes. Instead, we will pay an amount in cash based on the average of the high and low sales price of the common stock on the conversion date. If you deliver a note for conversion, you will not be required to pay any taxes or duties in respect of the issuance or delivery of common stock on conversion. However, you will be required to pay any tax or duty that may be payable in respect of any transfer involved in the issuance or delivery of the common stock in a name other than that of the holder of the note. We will not issue or deliver certificates representing shares of common stock unless the person requesting the issuance or delivery has paid to us the amount of any such tax or duty or has established to our satisfaction that no such tax or duty is payable. The conversion rate is subject to adjustment if, among other things: (1) there is a dividend or other distribution payable in common stock on shares of our common stock, (2) we issue to all holders of common stock rights, options or warrants entitling them to subscribe for or purchase common stock at less than the then current market price, calculated as described in the Indenture, of our common stock; however, if those rights, options or 35 36 warrants are only exercisable upon the occurrence of specified triggering events, then the conversion rate will not be adjusted until the triggering events occur, (3) we subdivide, reclassify or combine our common stock, (4) we distribute to all holders of our common stock evidences of our indebtedness, shares of capital stock, cash or assets, including securities, but excluding: - those dividends, rights, options, warrants and distributions referred to in paragraphs (1) and (2) above - dividends and distributions paid in cash (except as set forth in paragraphs (5) and (6) below), and - distributions upon a merger or consolidation as discussed below, (5) we make a distribution consisting exclusively of cash (excluding cash distributed upon a merger or consolidation as discussed below) to all holders of our common stock if the aggregate amount of the distribution combined together with (A) other such all cash distributions made within the preceding 365-day period in respect of which no adjustment has been made and (B) any cash and the fair market value of other consideration payable in respect of any tender offer by us or any of our subsidiaries for our common stock concluded within the preceding 365-day period in respect of which no adjustment has been made, exceeds 10% of our market capitalization, being the product of the current market price per share of our common stock on the record date for such distribution and the number of shares of common stock then outstanding, or (6) the successful completion of a tender offer made by us or any of our subsidiaries for our common stock that involves aggregate consideration that, together with (A) any cash and the fair market value of other consideration payable in a tender offer by us or any of our subsidiaries for our common stock concluded within the 365-day period preceding the completion of such tender offer in respect of which no adjustment has been made and (B) the aggregate amount of any such all cash distributions referred to in paragraph (5) above to all holders of common stock within the 365-day period preceding the expiration of such tender offer in respect of which no adjustments have been made, exceeds 10% of our market capitalization on the expiration of such tender offer. We reserve the right to make such increases in the conversion rate in addition to those required by the provisions described above as we may consider to be advisable so that any event treated for United States federal income tax purposes as a dividend of stock or stock rights will not be taxable to the recipients. No adjustment of the conversion rate will be required to be made until the cumulative adjustments amount to 1.0% or more of the conversion rate. We will compute any adjustments to the conversion rate and give notice to the holders of any such adjustments. If we merge or consolidate with another person or sell or transfer all or substantially all of our assets, each note then outstanding will, without the consent of the holder of any note, become convertible only into the kind and amount of securities, cash and other property receivable upon such consolidation, merger, sale or transfer by a holder of the number of shares of, common stock into which the note was convertible immediately prior to the merger, consolidation or sale. This 36 37 calculation will be made based on the assumption that the holder of common stock failed to exercise any fights of election that the holder may have had to select a particular type of consideration. The adjustment will not be made for a merger that does not result in any reclassification, conversion, exchange or cancellation of our common stock. We may, from time to time, increase the conversion rate by any amount for any period of at least 20 days if our board of directors has determined that such increase would be in our best interests. Any such determination will be conclusive. We will give holders of notes at least 15 days' notice of such an increase in the conversion rate. No such increase will be taken into account for purposes of determining whether the closing price of the common stock exceeds the conversion price by 105% in connection with an event which otherwise would be a Change in Control. If at any time we make a distribution of property to our stockholders that would be taxable to them as a dividend for United States federal income tax purposes (for example, distributions of evidences of indebtedness or assets of PDL, but generally not stock dividends on common stock or rights to subscribe for common stock) and, pursuant to the anti-dilution provisions of the Indenture, the number of shares into which notes are convertible is increased, that increase may be deemed for United States federal income tax purposes to be the payment of a taxable dividend to holders of notes. For more details, see "Certain Federal Income Tax Consequences." SUBORDINATION The payment of the principal of, premium, if any, and interest on the notes (including any Liquidated Damages and any amounts payable upon the redemption or repurchase of the notes that the Indenture permits) will be subordinated in right of payment to the extent set forth in the Indenture to the prior payment in full of all of our Senior Debt. "Senior Debt" means the principal of, and premium, if any, and interest, including all interest accruing subsequent to the commencement of any bankruptcy or similar proceeding, whether or not a claim for post-petition interest is allowable as a claim in any such proceeding, on, and all fees and other amounts payable in connection with, the following, whether absolute or contingent, secured or unsecured, due or to become due, outstanding on the date of the Indenture or thereafter created, incurred or assumed: - all our indebtedness evidenced by a credit or loan agreement, note, bond, debenture or other similar instrument - all our obligations for money borrowed - all our obligations as lessee under leases required to be capitalized on the balance sheet of the lessee under generally accepted accounting principles - all our obligations to our subsidiaries as lessee under facility leases - all our obligations under interest rate and currency swaps, caps, floors, collars, hedge agreements, forward contracts or similar agreements or arrangements - all our obligations with respect to letters of credit, bankers' acceptances and similar facilities, including related reimbursement obligations 37 38 - all our obligations issued or assumed as the deferred purchase price of property or services, but excluding trade accounts payable and accrued liabilities arising in the ordinary course of business - all our obligations of the type referred to above of another person and all dividends of another person, the payment of which, in either case, we have assumed or guaranteed, or for which we are responsible or liable, directly or indirectly, jointly or severally, as obligor, guarantor or otherwise, or which are secured by a lien on our property, and - renewals, extensions, modifications, replacements, restatements and refundings of, or any indebtedness or obligation issued in exchange for any indebtedness or obligation described in the bullets above. Senior Debt will not include any indebtedness or obligation if the terms of the indebtedness or obligation, or the terms of the instrument under which the indebtedness or obligation is issued, expressly provide that the indebtedness or obligation is not superior in right of payment to the notes. In addition, Senior Debt will not include trade payables and any indebtedness or obligation that we may owe to any of our direct or indirect subsidiaries, except for our obligations as lessee under facility leases. We will not make any payment on account of principal, premium or interest on the notes (including any Liquidated Damages and any amounts payable upon the redemption or repurchase of the notes) if either of the following occurs: - we default in our obligations to pay principal, premium, interest or other amounts on our Senior Debt, including a default under any redemption or repurchase obligation (a Payment Default), and the default continues beyond any grace period that we may have to make those payments, or - a default (other than a Payment Default) occurs and is continuing on any Designated Senior Debt (as defined below) and (1) the default permits the holders of the Designated Senior Debt to accelerate its maturity and (2) the trustee has received a notice (a Payment Blockage Notice) of the default from a holder of the Designated Senior Debt (or, in the case of a syndicated credit facility, the agent or representative of the lenders thereunder). If payments of the notes have been blocked by a Payment Default, payments on the notes may resume (including missed payments, if any) when the Payment Default has been cured or waived. If payments on the notes have been blocked by a default, other than a Payment Default, payments on the notes may resume (including missed payments, if any) on the earlier of (1) the date on which such default is cured or waived and (2) 179 days after the date on which the trustee receives the Payment Blockage Notice if the maturity of the Designated Senior Debt has not been accelerated, unless the Indenture otherwise prohibits payment at that time. No non-payment default that existed on the day a Payment Blockage Notice was delivered to the trustee can be used as the basis for any subsequent Payment Blockage Notice unless that existing non-payment default has been cured for a period of at least 90 days. In addition, once a holder of 38 39 Designated Senior Debt has blocked payment on the notes by giving a Payment Blockage Notice, no new period of payment blockage can be commenced until both of the following are satisfied: - 365 days have elapsed since the effectiveness of the immediately prior Payment Blockage Notice, and - all scheduled payments of principal, any premium and interest (and Liquidated Damages, if any) on the notes that have come due have been paid in full in cash. "Designated Senior Debt" means our obligations under any particular Senior Debt in which the instrument creating or evidencing the debt, or the assumption or guarantee of the debt, or related agreements or documents to which we are a party, expressly provides that the indebtedness will be Designated Senior Debt for purposes of the Indenture. That instrument, agreement or other document may place limitations and conditions on the right of that Senior Debt to exercise the rights of Designated Senior Debt. In addition, upon any acceleration of the principal due on the notes as a result of an Event of Default or payment or distribution of our assets to creditors upon any dissolution, winding up, liquidation or reorganization, whether voluntary or involuntary, marshaling of assets, assignment for the benefit of creditors, or in bankruptcy, insolvency, receivership or other similar proceedings, all principal, premium, interest and other amounts due on all Senior Debt must be paid in full in cash or cash equivalents before you will be entitled to receive any payment. Because of this subordination, in the event of insolvency, our creditors who are holders of Senior Debt may recover more, ratably, than you would, and this subordination may reduce or eliminate payments to you. The notes will be "structurally subordinated" to all indebtedness and other liabilities, including trade payables and lease obligations, of any of our subsidiaries. This occurs because any right we have to receive any assets of our subsidiaries upon their liquidation or reorganization, and the consequent right of the holders of the notes to participate in those assets, will be effectively subordinated to the claims of that subsidiary's creditors, including trade creditors, except to the extent that we are recognized as a creditor of the subsidiary, in which case our claims would still be subordinate to any security interest in the subsidiary's assets and any indebtedness of the subsidiary senior to that which we hold. As of December 31, 1999, our subsidiaries had indebtedness and other liabilities totaling approximately $10.1 million. The Indenture does not limit our ability to incur indebtedness, including Senior Debt, or the ability of any of our subsidiaries to incur indebtedness. OPTIONAL REDEMPTION On or after February 15, 2003, we may redeem the notes, in whole or in part, at our option, at the redemption prices specified below. The redemption price, expressed as a percentage of principal amount, is as follows for the 12-month periods beginning on February 15 of the following years: 39
YEAR REDEMPTION PRICE ---- ---------------- 2003 102.75% 2004 101.83% 2005 100.92% 40 and thereafter is equal to 100% of the principal amount. In each case, we will also pay accrued interest to the redemption date. The Indenture requires us to give notice of redemption not more than 60 and not less than 30 days before the redemption date. No "sinking fund" is provided for the notes, which means that the Indenture does not require us to redeem or retire the notes periodically. REPURCHASE AT OPTION OF HOLDERS UPON A CHANGE IN CONTROL If a Change in Control occurs, you will have the right, at your option, to require us to repurchase all of your notes not called for redemption, or any portion of the principal amount of your notes that is equal to $1,000 or any greater integral multiple of $1,000. The price we are required to pay is 100% of the principal amount of the notes to be repurchased, together with interest accrued to the repurchase date. At our option, instead of paying the repurchase price in cash, we may pay the repurchase price in our common stock, valued at 95% of the average of the high and low sales prices of the common stock for each of the five trading days ending with the third trading day prior to the repurchase date. We may only pay the repurchase price in common stock if we satisfy conditions provided in the Indenture. Because the number of shares of common stock to be delivered to holders of notes in payment of the repurchase price (should we elect such payment option) is determined on the basis of the market price of our common stock after we have given notice of the occurrence of the Change in Control and prior to the repurchase date, the value of the shares of common stock on the date of delivery thereof to such holders may be more or less than the repurchase price had we elected to pay such price in cash. Within 30 days after the occurrence of a Change in Control, we are obligated to give you notice of the Change in Control and of your repurchase right arising as a result of the Change in Control. We must also deliver a copy of this notice to the trustee. To exercise the repurchase right, you must deliver, on or before the 30th day (or such greater period as may be required by applicable law) after the date of our notice, irrevocable written notice to the trustee of your exercise of your repurchase right, together with the notes with respect to which that right is being exercised. We are required to make the repurchase on a date that is no later than 45 days after your notice to the trustee. 40 41 A Change in Control will be deemed to have occurred if any of the following occurs: (1) any person, including any syndicate or group deemed to be a "person" under Section 13 (d) (3) of the Exchange Act, (A) acquires beneficial ownership, directly or indirectly, through a purchase, merger or other acquisition transaction or series of transactions, of shares of our capital stock entitling that person to exercise more than 50% of the total voting power of all shares of our capital stock entitled to vote generally in elections of directors; however, any acquisition by us, any of our subsidiaries or any of our employee benefit plans will not trigger this provision or (B) succeeds in having sufficient of its nominees (who are not supported by a majority of the then current board of directors) elected to the board of directors such that such nominees, when added to any existing directors remaining on the board of directors after such election who are affiliates of or acting in concert with such person, shall constitute a majority of the board of directors, (2) we consolidate with or merge with or into any other person or another person merges into us, except if the transaction satisfies any of the following: - the transaction is a merger (A) that does not result in any reclassification, conversion, exchange or cancellation of outstanding shares of our capital stock and (B) pursuant to which holders of our common stock immediately prior to the transaction have, directly or indirectly, 50% or more of the total voting power of all shares of capital stock or other ownership interest of the continuing or surviving person entitled to vote generally in elections of directors of the continuing or surviving person immediately after the transaction, or - the transaction is a merger effected only to change our jurisdiction of incorporation and it results in a reclassification, conversion or exchange of outstanding shares of our common stock only into shares of common stock of us or another corporation, or (3) we convey, transfer, sell, lease or otherwise dispose of all or substantially all of our assets to another person. However, a Change in Control will not be deemed to have occurred if the average of the high and low sales price per share of our common stock for any five trading days within (A) the period of 10 consecutive trading days ending immediately after the later of the Change in Control and the public announcement of the Change in Control, in the case of a Change in Control relating to an acquisition of capital stock not involving a merger or consolidation covered by clause (B) below, or (B) the period of 10 consecutive trading days ending immediately before the Change in Control, in the case of Change in Control relating to a merger, consolidation or asset sale, in each case, equals or exceeds 105% of the conversion price of the notes in effect on each of those trading days. For purposes of these provisions: - the conversion price is equal to $1,000 divided by the conversion rate, and - whether a person is a "beneficial owner" will be determined in accordance with Rule 13d-3 under the Exchange Act. 41 42 Any repurchase of notes arising as a result of the Change in Control will be made in compliance with all applicable laws, rules and regulations, including, if applicable, Regulation 14E under the Exchange Act and the rules thereunder and all other applicable federal and state securities laws. To the extent the provisions of any securities laws or regulations conflict with the provisions of this covenant, our compliance with such laws and regulations shall not be deemed to cause a breach of our obligations under the Indenture. We may, to the extent permitted by applicable law, at any time purchase notes in the open market or by tender at any price or by private agreement. Any note that we so purchase may, to the extent permitted by applicable law, be reissued or resold or may, at our option, be surrendered to the trustee for cancellation. Any notes surrendered may not be reissued or resold and will be canceled promptly. The definition of Change in Control includes a phrase relating to the conveyance, transfer, sale, lease or disposition of "all or substantially all" of our assets. There is no precise, established definition of the phrase "substantially all" under applicable law. Accordingly, your ability to require us to repurchase your notes as a result of conveyance, transfer, sale, lease or other disposition of less than all of our assets may be uncertain. The foregoing provisions would not necessarily provide you with protection if we are involved in a highly leveraged or other transaction that may adversely affect you. Our ability to repurchase notes upon the occurrence of a Change in Control is subject to important limitations. Some of the events constituting a Change in Control could cause an event of default or be prohibited or limited by the terms of Senior Debt. As a result, any repurchase of the notes would, absent a waiver, be prohibited under the Indenture's subordination provisions until the Senior Debt is paid in full. Further, we may not have the financial resources, or would be unable to arrange financing to pay the repurchase price for all the notes that holders seeking to exercise their repurchase right deliver to us. If we were to fail to repurchase the notes when required following a Change in Control, an Event of Default would occur, whether or not such repurchase is permitted by the Indenture's subordination provisions. Any such default may, in turn, cause a default under our Senior Debt. For more details, see "Subordination." MERGERS AND SALES OF ASSETS Pursuant to the terms of the Indenture, we may not consolidate with or merge into any other person or convey, transfer, sell or lease our properties and assets substantially as an entirety to any person, and we may not permit any person to consolidate with or merge into us or convey, transfer, sell or lease such person's properties and assets substantially as an entirety to us, unless each of the following requirements is met: - the person formed by the consolidation or into or with which we merge or the person to which our properties and assets are conveyed, transferred, sold or leased, is (A) a corporation, limited liability company, partnership or trust organized and existing under the laws of the United States, any State or the District of Columbia or (B) organized under the laws of a jurisdiction outside the U.S. and has (x) common stock or American Depositary Shares representing such common stock traded on a national securities exchange in the U.S., including The Nasdaq Stock Market, Inc. 42 43 and (y) a worldwide total market capitalization of its equity securities (before giving effect to such consolidation or merger) of at least US$5 billion and, in each case, if other than us, expressly assumes the due and punctual payment of the principal of, any premium, and interest (and Liquidated Damages, if any) on the notes and the performance of our other covenants under the Indenture - immediately after giving effect to that transaction, no Event of Default, and no event that, after notice or lapse of time or both, would become an Event of Default, shall have occurred and be continuing, and - an officer's certificate and legal opinion relating to these conditions is delivered to the trustee. EVENTS OF DEFAULT The following will be Events of Default under the Indenture: - we fail to pay principal of or any premium on any note when due, whether or not the payment is prohibited by the Indenture's subordination provisions - we fail to pay any interest on any note when due and that default continues for 30 days, whether or not the payment is prohibited by the Indenture's subordination provisions - we fail to give the notice that we are required to give if there is a Change in Control, whether or not the notice is prohibited by the Indenture's subordination provisions - we fail to perform any other covenant in the Indenture and that failure continues for 60 days after written notice to us by the trustee or the holders of at least 25% in aggregate principal amount of outstanding notes - we fail to pay when due the principal of any indebtedness for money borrowed by us or any of our subsidiaries, if any, in excess of $10 million if the indebtedness is not discharged and such failure continues for 20 days or more, or, if such indebtedness has been accelerated, such acceleration is not annulled, within 30 days after written notice to us by the trustee or the holders of at least 25% in aggregate principal amount of the outstanding notes, and - events of bankruptcy, insolvency or reorganization with respect to us and our significant subsidiaries specified in the Indenture. Subject to the provisions of the Indenture relating to the trustee's duties, if an Event of Default exists, the trustee will not be obligated to exercise any of its rights or powers under the Indenture at the request or direction of any of the holders, unless they have offered to the trustee reasonable indemnity. Subject to such trustee indemnification provisions, the holders of a majority in aggregate principal amount of the outstanding notes will have the right to direct the time, method and place of conducting any proceeding for any remedy available to the trustee or exercising any trust or power conferred on the trustee, provided that such direction does not conflict with any rule of law or with 43 44 the Indenture, and the trustee may take any other action the trustee deems proper which is not inconsistent with such direction. If an Event of Default, other than an Event of Default arising from events of bankruptcy, insolvency or reorganization, occurs and is continuing, either the trustee or the holders of at least 25% in principal amount of the outstanding notes may accelerate the maturity of all notes. After acceleration, but before a judgment or decree based on acceleration, the holders of a majority in aggregate principal amount of outstanding notes may, under circumstances set forth in the Indenture, rescind the acceleration if all Events of Default, other than the non-payment of principal of the notes which have become due solely because of the acceleration, have been cured or waived as provided in the Indenture. If an Event of Default arising from events of bankruptcy, insolvency or reorganization occurs and is continuing, then the principal of, and accrued interest (and Liquidated Damages, if any) on, all of the notes will automatically become immediately due and payable without any declaration or other act an the part of the holders of the notes or the trustee. Before you may take any action to institute any proceeding relating to the Indenture, or to appoint a receiver or a trustee, or for any other remedy, each of the following must occur: - you must have given the trustee written notice of a continuing Event of Default - the holders of at least 25% of the aggregate principal amount of all outstanding notes must make a written request of the trustee to take action because of the default and must have offered reasonable indemnification to the trustee against the cost, liabilities and expenses of taking such action, and - the trustee must not have taken action for 60 days after receiving such notice and offer of indemnification. These limitations do not apply to a suit for the enforcement of payment of the principal of, or any premium or interest (and Liquidated Damages, if any) on, a note, or the repurchase price payable for a note on or after the due dates for such payments, or of the right to convert the note in accordance with the Indenture. We will furnish to the trustee annually a statement as to our performance of our obligations under the Indenture and as to any default in performance. MODIFICATION AND WAIVER The Indenture will contain provisions permitting us and the trustee to enter into a supplemental indenture for certain limited purposes without the consent of the holders of the notes. With the consent of the holders of not less than a majority in aggregate principal amount of the notes at the time outstanding, we and the trustee are permitted to amend or supplement the Indenture or any supplemental indenture or modify the rights of the holders, provided, that no such modification may, without the consent of each holder affected thereby: - change the stated maturity of the principal or interest of a note - reduce the principal amount, any premium or interest on any note 44 45 - reduce the amount payable upon a redemption at our option - amend or modify our obligation to make or consummate a repurchase offer upon a Change in Control after our obligation to make a Change in Control repurchase offer arises - change the place or currency of payment on a note - impair the right to institute suit for the enforcement of any payment on any note - modify the subordination provisions in a manner that is adverse to the holders of the notes - adversely affect the right of holders of notes to convert any of the notes - reduce the percentage of holders whose consent is needed to modify, amend or waive any provision in the Indenture, or - modify the provisions dealing with modification and waiver of the Indenture, except to increase any required percentage or to provide that certain other provisions of the Indenture cannot be modified or waived without the consent of the holder of each outstanding note affected thereby. The holders of a majority in principal amount of the outstanding notes must consent to waive our compliance with certain restrictive provisions of the Indenture. The holders of a majority in principal amount of the outstanding notes may waive any past default, except a default in the payment of principal, any premium, interest or the repurchase price (or Liquidated Damages, if any). Notes will not be considered outstanding if money for their payment or redemption has been deposited or set aside in trust for the holders. SATISFACTION AND DISCHARGE The Indenture will be discharged and will cease to be of further effect (except as to any surviving rights of conversion, or registration of transfer or exchange, or replacement of notes, any right to receive Liquidated Damages and our obligations to the trustee) as to all outstanding notes when: (1) either (A) all notes theretofore authenticated and delivered (other than (x) notes that have been destroyed, lost or stolen and which have been replaced or paid as provided in the Indenture and (y) notes for which payment money has theretofore been deposited in trust or segregated and held in trust by us and thereafter repaid to us or discharged from such trust, as provided in the Indenture) have been delivered to the trustee for cancellation, or (B) all such notes not theretofore delivered to the trustee or its agent for cancellation (other than notes referred to in clauses (x) and (y) of clause (1) (A) above) (I) have become due and payable, or 45 46 (II) will become due and payable within one year, or (III) are to be called for redemption within one year under arrangements satisfactory to the trustee for the giving of notice of redemption by the trustee in our name, and at our expense, and we, in the case of clause (I), (II) or (III) above, have deposited with the trustee as trust funds (immediately available to the holders of the notes in the case of clause (I)) an amount sufficient to pay and discharge the entire principal, premium, if any, and interest (and Liquidated Damages, if any) on such notes to the date of deposit (in the case of notes which have become due and payable) or to the final maturity or redemption date, as the case may be, and (2) we have paid all other sums payable by us under the Indenture. In addition, we must deliver an officers' certificate stating that all conditions precedent to satisfaction and discharge have been complied with. REGISTRATION RIGHTS We entered into a registration rights agreement (the Registration Rights Agreement) with CIBC World Markets Corp., Credit Suisse First Boston Corporation, SG Cowen Securities Corporation and Warburg Dillon Read LLC (the Initial Purchasers) on February 15, 2000. In the Registration Rights Agreement we agreed, for the benefit of the holders of the notes and the shares of common stock issuable upon conversion of the notes (together, the Registrable Securities, but excluding securities that are eligible for disposition under Rule 144 of the Securities Act) that we would, at our expense: - file with the SEC, on or prior to 90 days following February 15, 2000, the date the notes were originally issued, a shelf registration statement covering resales of the Registrable Securities - use all reasonable efforts to cause the shelf registration statement to be declared effective under the Securities Act on or prior to 180 days following February 15, 2000, the date the notes were originally issued, and - use all reasonable efforts to keep effective the shelf registration statement until the earlier of (1) the sale under the shelf registration statement of all the securities registered thereunder and (2) the expiration of the holding period applicable to such securities held by persons that are not our affiliates under Rule 144(k) under the Securities Act or any successor provision, subject to specific permitted exceptions (the Effectiveness Period). We agreed to provide to each holder of Registrable Securities copies of the prospectus that is a part of the shelf registration statement, notify each holder when the shelf registration statement has become effective and take certain other actions required to permit public resales of the Registrable Securities. Upon written notice to all the holders of notes, we will be permitted to suspend the use of the prospectus that is part of the shelf registration statement in connection with sales of Registrable 46 47 Securities during prescribed periods of time if we possess material non-public information the disclosure of which would have a material adverse effect on us. The periods during which we can suspend the use of the prospectus may not exceed a total of 60 consecutive days. Upon receipt of such notice, the holders of notes are required to cease disposing of securities under the prospectus and to keep the notice confidential. Liquidated damages (Liquidated Damages) will accrue if any of the following events (Registration Defaults) occurs: - on or prior to 90 days following February 15, 2000, the date the notes were originally issued, a shelf registration statement has not been filed with the SEC - on or prior to 180 days following February 15, 2000, the date the notes were originally issued, the SEC does not declare the shelf registration statement effective, or - the shelf registration statement ceases to be effective, or we otherwise prevent or restrict holders of Registrable Securities from making sales under the shelf registration statement, for more than 60 consecutive days. In any case, Liquidated Damages will accrue at a rate of 0.5% of the principal amount per annum from and including the day following the Registration Default to but excluding the day on which the Registration Default is cured. Liquidated Damages will be paid semi-annually in arrears, with the first semi-annual payment due on the first Interest Payment Date following the date on which the Liquidated Damages begin to accrue. A holder who elects to sell any Registrable Securities pursuant to the shelf registration statement will be required to be named as a selling security holder in the related prospectus, may be required to deliver a prospectus to purchasers, may be subject to certain civil liability provisions under the Securities Act in connection with those sales and will be bound by the provisions of the Registration Rights Agreement that apply to a holder making such an election, including certain indemnification provisions. We mailed a notice and questionnaire to the holders of Registrable Securities not less than 30 calendar days prior to the time we intended in good faith to have the shelf registration statement declared effective (the Effective Time). No holder of Registrable Securities was entitled to be named as a selling security holder in the shelf registration statement as of the Effective Time, and no holder of Registrable Securities was entitled to use the prospectus forming a part of the shelf registration statement for offers and resales of Registrable Securities at any time, unless such holder had returned a completed and signed notice and questionnaire to us by the deadline for response set forth in the notice and questionnaire. Holders of Registrable Securities, however, had at least 20 calendar days from the date on which the notice and questionnaire was first mailed to them to return a completed and signed notice and questionnaire to us. Beneficial owners of Registrable Securities who had not returned a notice and questionnaire by the questionnaire deadline described above may receive another notice and questionnaire from us upon request. When we receive a completed and signed notice and questionnaire prior to the Effective 47 48 Date of the Registration Statement, we will include the Registrable Securities covered thereby in the shelf registration statement, subject to restrictions on the timing and number of supplements to the shelf registration statement provided in the Registration Rights Agreement. We agreed in the Registration Rights Agreement to use our reasonable efforts to cause the shares of common stock issuable upon conversion of the notes to be quoted on The Nasdaq National Market. However, if the common stock is not then quoted on The Nasdaq National Market, we will use our reasonable efforts to cause the shares of common stock issuable upon conversion of the notes to be quoted or listed on whichever market or exchange the common stock is then quoted or listed, if any, on or prior to the effectiveness of the shelf registration statement. This summary of certain provisions of the Registration Rights Agreement is not complete and is subject to, and qualified in its entirety by reference to, all the provisions of the Registration Rights Agreement, a copy of which we will make available to beneficial owners of the notes upon request to us. We gave notice to holders of the notes by mail to the addresses of the holders as they appear in the Security Register. Notices are deemed to have been given on the date of mailing. REPLACEMENT OF NOTES We will replace, at the holders' expense, notes that become mutilated, destroyed, stolen or lost upon delivery to the trustee of the mutilated notes or evidence of the loss, theft or destruction thereof satisfactory to us and the trustee. In the case of a lost, stolen or destroyed note, indemnity satisfactory to the trustee and us may be required at the expense of the holder of the note before a replacement note will be issued. NO PERSONAL LIABILITY OF STOCKHOLDERS, OFFICERS, DIRECTORS AND EMPLOYEES No direct or indirect stockholder, officer, director or employee, as such, past, present or future of PDL, or any successor entity, shall have any personal liability in respect of our obligations under the Indenture or the notes solely by reason of his or its status as such stockholder, officer, director or employee. THE TRUSTEE The trustee for the holders of notes issued under the Indenture is Chase Manhattan Bank and Trust Company, N. A. If an Event of Default occurs, and is not cured, the trustee will be required to use the degree of care of a prudent person in the conduct of his own affairs in the exercise of its powers. Subject to these provisions, the trustee will be under no obligation to exercise any of its rights or powers under the Indenture at the request of any holders of notes, unless they have offered the trustee reasonable security or indemnity. 48 49 DESCRIPTION OF CAPITAL STOCK This summary does not purport to be complete and is subject to, and qualified in its entirety by, the provisions of our certificate of incorporation, as amended, and all applicable provisions of Delaware law. GENERAL We are authorized to issue 40,000,000 shares of common stock, $.01 par value, and 10,000,000 shares of preferred stock, $.01 par value. COMMON STOCK As of March 31, 2000, we had issued and outstanding approximately 19,573,677 shares of common stock held of record by approximately 127 stockholders. Holders of common stock are entitled to one vote per share for the election of directors and all other matters submitted to a vote of our stockholders. Subject to the rights of any holders of preferred stock that may be issued in the future, the holders of common stock are entitled to share ratably in such dividends as may be declared by our board of directors out of funds legally available therefor. In the event of our dissolution, liquidation or winding up, holders of common stock are entitled to share ratably in all assets remaining after payment of all liabilities and liquidation preferences of any preferred stock. Holders of common stock have no preemptive, subscription, redemption, conversion rights or similar rights. Our certificate of incorporation does not provide for cumulative voting rights with respect to the election of directors. All outstanding common stock is, and the common stock issuable on conversion of the notes will be, fully paid and nonassessable. Shares of the Company's common stock are reserved for issuance under the Company's option and employee stock purchase plans, and there are options outstanding under the Company's stock plans for shares of common stock. PREFERRED STOCK Our board of directors has the authority, without any action by our stockholders, to issue preferred stock in one or more series with such designations, rights and preferences (including dividend, conversion, voting or other rights or liquidation preferences) as determined by our board of directors. The issuance of preferred stock could delay, defer or prevent a change of control of PDL and could decrease the amount of earnings and assets available for distribution to, or adversely affect the voting power or other rights of, holders of common stock. In addition, the issuance of preferred stock could have the effect of decreasing the market price of our common stock. At present, there are no shares of preferred stock outstanding. TRANSFER AGENT The transfer agent for our common stock is ChaseMellon Shareholder Services, L.L.C. Its address is 235 Montgomery Street, 23rd Floor, San Francisco, California 94104. Its telephone number is (415) 743-1444. 49 50 CERTAIN FEDERAL INCOME TAX CONSIDERATIONS The following is a summary of certain United States federal income tax considerations relating to the purchase, ownership and disposition of the notes, but does not purport to be a complete analysis of all the potential tax considerations relating thereto. This summary is based on laws, regulations, rulings and decisions now in effect, all of which are subject to change. This summary deals only with holders that will hold notes as "capital assets" within the meaning of Section 1221 of the Internal Revenue Code of 1986, as amended, which we sometimes refer to as the Code and does not address tax considerations applicable to investors that may be subject to special tax rules, such as banks, tax-exempt organizations, insurance companies, dealers in securities or currencies, persons that will hold notes as a position in a hedging transaction, "straddle" or "conversion transaction" for tax purposes or persons deemed to sell notes under the constructive sale provisions of the Code. For purposes of this summary, the term "U.S. Holder" means a holder that is, as determined for United States federal income tax purposes, either (1) a citizen or resident of the United States, or U.S.; (2) an entity formed under the laws of the U.S. or a state of the U.S.; (3) an estate the income of which is subject to U.S. federal income tax regardless of its source; or (4) a trust subject to the primary supervision of a court within the U.S. and the control of a U.S. fiduciary as described in Section 7701(a)(30). A "Non-U.S. Holder" is any holder other than a U.S. Holder. We have not sought any ruling from the Internal Revenue Service with respect to the statements made and the conclusions reached in the following summary, and there can be no assurance that the IRS will agree with such statements and conclusions. In addition, the IRS is not precluded from successfully adopting a contrary position. This summary does not consider the effect of any applicable foreign, state, local or other tax laws. HOLDERS OF NOTES SHOULD CONSULT THEIR OWN TAX ADVISORS WITH RESPECT TO THE APPLICATION OF THE UNITED STATES FEDERAL INCOME AND ESTATE TAX LAWS TO THEIR PARTICULAR SITUATIONS AS WELL AS ANY TAX CONSEQUENCES ARISING UNDER THE LAWS OF ANY STATE, LOCAL OR FOREIGN TAXING JURISDICTION OR UNDER ANY APPLICABLE TAX TREATY. U.S. HOLDERS Taxation of Interest Interest paid on the notes will be included in the income of a holder as ordinary income at the time it is treated as received or accrued, in accordance with the holder's regular method of tax accounting. Our failure to maintain the effectiveness of the registration statement will cause additional interest to accrue on the notes in the manner described under "Description of the Notes -- Registration Rights." According to Treasury Regulations, the possibility of a change in the interest rate due to our obligation to pay Liquidated Damages (see "Description of the Notes--Registration Rights") will not affect the amount of interest income recognized by a holder, or the timing of such recognition, if the likelihood of the change, as of the date the notes are issued, is remote. We believe that the likelihood of a change in the interest rate on the notes is remote and do not intend to treat the possibility of a change in the interest rate as affecting the yield to maturity of any note. Similarly, we intend to take the position that the occurrence of an event requiring us to repurchase the notes is remote under the Treasury Regulations, and likewise does not intend to treat the possibility of the 50 51 occurrence of an event requiring us to repurchase the notes as affecting the yield to maturity of any note. Market Discount "Market discount" will exist if the stated redemption price at maturity exceeds the U.S. Holder's initial tax basis in the note. If the market discount is less than 0.25% of the stated redemption price of the note at maturity multiplied by the number of complete years to maturity, then the market discount will be deemed to be zero. A U.S. Holder may elect to include market discount in income currently as it accrues. Any such election will apply to all market discount bonds acquired during or after the year for which the election is made, and the election may be terminated only with the consent of the Internal Revenue Service. If a U.S. Holder does not make an election to include market discount in income currently as it accrues, any principal amount received or gain realized by a U.S. Holder on the sale, exchange, retirement or other taxable disposition of a note will be treated as ordinary income to the extent of any accrued market discount on the note. Unless a U.S. holder irrevocably elects to accrue market discount under a constant-interest method, accrued market discount is the total market discount multiplied by a fraction, the numerator of which is the number of days the U.S. Holder has held the note and the denominator of which is the number of days from the date the holder acquired the note until its maturity. If a U.S. Holder exchanges or converts a note into our common stock in a transaction that is otherwise tax free, any accrued market discount will carry over and generally be recognized upon a disposition of our common stock. A U.S. Holder may be required to defer a portion of such holder's interest deductions for the taxable year attributable to any indebtedness incurred or continued to purchase or carry a note purchased with market discount. Any such deferred interest expense may not exceed the market discount that accrues during a taxable year and is, in general, allowed as a deduction not later than the year in which the market discount is includible in income. This interest expense deferral will not apply if a U.S. Holder makes an election to include market discount in income currently as it accrues. Market Premium A "market premium" will exist if a U.S. Holder's initial tax basis in a note is greater than the stated redemption price at maturity of such note. If an election is made, the market premium may be amortized using a constant yield method, over the remaining term of the note, or, if shorter, over the period from the date of purchase to the date of an assumed redemption option exercise. We will be presumed to exercise our option to redeem the notes if, by using the date of exercise of the call option as the maturity date and the redemption price as the stated redemption price at maturity, the yield on the notes would be lower than such yield would be if the option were not exercised. A U.S. Holder may deduct any remaining market premium upon redemption if a note is redeemed prior to the time at which it is assumed that the note would be redeemed. Interest otherwise required to be included in income with respect to the note during any tax year may be offset by the amount of any amortized market premium. An election to amortize market premium will apply to all market premium bonds acquired during or after the year for which the election is made, and the election may be terminated only with the consent of the Internal Revenue Service. 51 52 Sale, Exchange or Redemption of the Notes Upon the sale, exchange, retirement or other taxable disposition of a note, a holder will recognize gain or loss equal to the difference between the amount received on such disposition (other than amounts received in respect of accrued and unpaid interest, which will be taxable as such) and the holder's tax basis in the note. A holder's tax basis in a note will be, in general, the cost of the note to the holder, increased by any accrued market discount and decreased by any principal payments received and any amortizable market premium accrued. Except to the extent of any accrued market discount, gain or loss realized on the sale, exchange or retirement of a note generally will be capital gain or loss, and will be long-term capital gain or loss if, at the time of such sale, exchange or retirement, the note had been held for more than one year. Long-term capital gain recognized by an individual holder is generally subject to a maximum U.S. federal rate of 20%; an individual's ability to offset capital losses against ordinary income is, however, limited. Conversion of the Notes A holder will generally not recognize income, gain or loss upon conversion of the note into our common stock, except with respect to any cash received in lieu of a fractional share (which will generally result in capital gain or loss). The holder's tax basis in the common stock received upon conversion will be the same as the holder's tax basis in the note at the time of conversion (exclusive of any tax basis allocable to a fractional share), and the holding period for the our common stock received upon conversion will include the holding period of the note converted. Adjustment to Conversion Price Holders of convertible debt instruments such as the notes may, in certain circumstances, be deemed to have received constructive distributions where the conversion ratio of such instruments is adjusted. Adjustments to the conversion price made pursuant to a bona fide reasonable adjustment formula which has the effect of preventing the dilution of the interest of the holders of the debt instruments, however, will generally not be considered to result in a constructive distribution of stock. Certain of the possible adjustments provided in the notes, including, without limitation, adjustments in respect of taxable dividends to our stockholders, will not qualify as being pursuant to a bona fide reasonable adjustment formula. If such adjustments are made, the holders of notes might be deemed to have received constructive distributions taxable as dividends. Moreover, in certain other circumstances, the failure to adjust the conversion ratio on the notes may result in a deemed taxable dividend to holders of our common stock. Sale of Common Stock: Upon the sale or exchange of our common stock, a holder generally will recognize capital gain or loss equal to the difference between - the amount of cash and the fair market value of any property received upon the sale or exchange, and - such holder's adjusted tax basis in the our common stock. Such capital gain or loss will be long-term capital gain or loss if the holder's holding period in our common stock is more than one year at the time of the sale or exchange. A holder's basis and 52 53 holding period in our common stock received upon conversion of a note are determined as discussed above under "Conversion of the Notes." Information Reporting and Backup Withholding Tax In general, information reporting requirements will apply to payments of principal, premium, if any, and interest on a note, payments of dividends on our common stock, payments of the proceeds of the sale of a note and payments of the proceeds of the sale of our common stock, and a 31% backup withholding tax may apply to such payments if the holder either: - fails to demonstrate that the holder comes within certain exempt categories of holders or - fails to furnish or certify his correct taxpayer identification number to the payor in the manner required, - is notified by the IRS that he has failed to report payments of interest and dividends properly, or - under certain circumstances, fails to certify that he has not been notified by the IRS that he is subject to backup withholding for failure to report interest and dividend payments. Any amounts withheld under the backup withholding rules from a payment to a holder will be allowed as a credit against such holder's United States federal income tax and may entitle the holder to a refund, provided that the required information is furnished to the IRS. NON-U.S. HOLDERS The following discussion is limited to the U.S. federal income tax consequences relevant to a Non-U.S. Holder. For purposes of withholding tax on interest and dividends discussed below, a Non-U.S. Holder (as defined above) includes a non-resident fiduciary of an estate or trust. For purposes of the following discussion, interest, dividends and gain on the sale, exchange or other disposition of a note or common stock will be considered to be "U.S. trade or business income" if such income or gain is (1) effectively connected with the conduct of a U.S. trade or business or (2) in the case of a treaty resident, attributable to a permanent establishment (or, in the case of an individual, a fixed base) in the United States. Taxation of Interest Generally any interest paid to a Non-U.S. Holder of a note that is not U.S. trade or business income will not be subject to U.S. tax if the interest qualifies as "portfolio interest." Generally interest on the notes will qualify as portfolio interest if: - the Non-U.S. Holder does not actually or constructively own 10% or more of the total voting power of all PDL voting stock and is not a "controlled foreign 53 54 corporation" with respect to which PDL is a "related person" within the meaning of the Code - the beneficial owner, under penalty of perjury, certifies that the beneficial owner is not a U.S. person and such certificate provides the beneficial owner's name and address, and - the Non-U.S. Holder is not a bank receiving interest on an extension of credit made pursuant to a loan agreement made in the ordinary course of its trade or business. The gross amount of payments of interest to a Non-U.S. Holder that do not qualify for the portfolio interest exemption and that are not U.S. trade or business income will be subject to U.S. federal income tax at the rate of 30%, unless a U.S. income tax treaty applies to reduce or eliminate withholding. U.S. trade or business income will be taxed at regular U.S. rates rather than the 30% gross rate. In the case of a Non-U.S. Holder that is a corporation, such U.S. trade or business income may also be subject to the branch profits tax (which is generally imposed on a foreign corporation on the actual or deemed repatriation from the United States of earnings and profits attributable to U.S. trade or business income) at a 30% rate. The branch profits tax may not apply (or may apply at a reduced rate) if a recipient is a qualified resident of certain countries with which the United States has an income tax treaty. To claim the benefit of a tax treaty or to claim exemption from withholding because the income is U.S. trade or business income, the Non-U.S. Holder must provide a properly executed Form W-8 BEN or W-8 ECI (or such successor forms as the IRS designates), as applicable, prior to the payment of interest. These forms must be periodically updated. Under new regulations which are effective with respect to payments made after December 31, 2000, a Non-U.S. Holder who is claiming the benefits of a treaty may be required to obtain a U.S. taxpayer identification number, which may require providing certain documentary evidence issued by foreign governmental authorities to prove residence in the foreign country. Certain special procedures are provided in such new regulations for payments through qualified intermediaries. Sales, Exchange or Redemption of the Notes Except as described below and subject to the discussion concerning backup withholding, any gain realized by a Non-U.S. Holder on the sale, exchange or redemption of a note generally will not be subject to U.S. federal income tax, unless: - such gain is U.S. trade or business income - subject to certain exceptions, the Non-U.S. Holder is an individual who holds the note as a capital asset and is present in the United States for 183 days or more in the taxable year of the disposition - the Non-U.S. Holder is subject to tax pursuant to the provisions of U.S. tax law applicable to certain U.S. expatriates (including certain former citizens or residents of the United States, or - in the case of the disposition of PDL common stock, PDL is a U.S. real property holding corporation. 54 55 PDL does not believe that it is currently a "United States real property holding corporation," or that it will become one in the future. Conversion of the Notes A Non-U.S. Holder generally will not be subject to U.S. federal income tax on the conversion of notes into our common stock, except with respect to cash (if any) received in lieu of a fractional share or interest which does not qualify for the portfolio interest exemption, is not U.S. trade or business income and has not previously included in income. Cash received in lieu of a fractional share may give rise to gain that would be subject to the rules described below for the sale of notes. Cash or common stock treated as issued for accrued interest would be treated as interest under the rules described above. Information Reporting and Backup Withholding Tax We must report annually to the IRS and to each Non-U.S. Holder any interest or dividend that is subject to withholding or is exempt from U.S. withholding tax pursuant to a tax treaty, or interest that is exempt from U.S. tax under the portfolio interest exception. Copies of these information returns may also be made available under the provisions of a specific treaty or agreement to the tax authorities of the country in which the Non-U.S. Holder resides. Treasury Regulations provide that backup withholding and additional information reporting will not apply to payments of principal on the notes by us to a Non-U.S. Holder if the holder certifies as to its Non-U.S. status under penalties of perjury or otherwise establishes an exemption (provided that neither we nor our paying agent have actual knowledge that the holder is a U.S. person or that the conditions of any other exemption are not, in fact, satisfied). As a general matter, information reporting and backup withholding will not apply to a payment of the proceeds of a sale of notes or common stock effected outside the United States by a foreign office of a foreign broker. However, information reporting requirements (but not backup withholding) will apply to a payment of the proceeds of a sale of notes or common stock effected outside the United States by a foreign office of a broker if the broker: - is a U.S. person - derives 50% or more of its gross income for certain periods from the conduct of a trade or business in the United States - is a "controlled foreign corporation" as to the United States, or - with respect to payments made after December 31, 2000, is a foreign partnership that, at any time during its taxable year is 50% or more (by income or capital interest) owned by U.S. persons or is engaged in the conduct of a U.S. trade or business unless the broker has documentary evidence in its records that the holder is a non-U.S. holder and certain conditions are met, or the holder otherwise establishes an exemption. 55 56 Payment by a United States office of a broker of the proceeds of a sale of notes or common stock will be subject to both backup withholding and information reporting unless the holder certifies its non-United States status under penalties of perjury or otherwise establishes an exemption. New regulations, generally effective with respect to payments made after December 31, 2000, make certain modifications to the withholding, backup withholding and information reporting rules described above. The new regulations generally attempt to unify certification requirements and modify reliance standards. Prospective investors are urged to consult their own tax advisors regarding the new regulations. Any amounts withheld under the backup withholding rules from a payment to a Non-U.S. Holder will be allowed as a refund or a credit against such Non-U.S. Holder's U.S. federal income tax liability, provided that the requisite procedures are followed. 56 57 SELLING SECURITY HOLDERS The notes offered hereby were issued by us and sold by the Initial Purchasers in a transaction exempt from the registration requirements of the Securities Act to persons reasonably believed by the Initial Purchasers to be "qualified institutional buyers" (as defined in Rule 144A under the Securities Act). The selling security holders (which term includes the Initial Purchasers' transferees, pledgees, donees or their successors) may from time to time offer and sell pursuant to this prospectus any or all of the notes and common stock issued upon conversion of the notes. The following table sets forth information, as of March 30, 2000, with respect to the selling security holders and the respective principal amounts of notes beneficially owned by each selling security holder that may be offered pursuant to this prospectus. Such information has been obtained from the selling security holders. None of the selling security holders has, or within the past three years has had, any position, office or other material relationship with us or any of our predecessors or affiliates. Because the selling security holders may offer all or some portion of the notes or the common stock issuable upon conversion of the notes pursuant to this prospectus, no estimate can be given as to the amount of the notes or the common stock issuable upon conversion of the notes that will be held by the selling security holders upon termination of any such sales. In addition, the selling security holders identified below may have sold, transferred or otherwise disposed of all or a portion of their notes since the date on which they provided the information regarding their notes in transactions exempt from the registration requirements of the Securities Act. 57 58 58
Principal Amount Number of Shares of of Notes Common Stock ---------------- --------------------------------------------- Beneficially Owned and Offered Beneficially Offered Owned After Selling Security Holder (1) Hereby (1) Owned(1)(2) Hereby the Offering - ------------------------------------------------------- ----------------- ------------ ------------- --------------- AIG/National Union Fire Insurance $ 1,100,000 7,284 7,284 -- AIG SoundShore Strategic Holdings Fund $ 300,000 1,986 1,986 -- Ltd. AIG SoundShore Opportunity Holding Fund $ 3,500,000 23,178 23,178 -- Ltd. AIG Soundshore Holdings Ltd. $ 2,700,000 17,880 17,880 -- Allstate Insurance Company $ 500,000 11,911 3,311 8,600 Aloha Airlines Non-Pilots Pension Trust $ 75,000 496 496 -- Aloha Airlines Pilots Retirement Trust $ 45,000 298 298 -- Alta Partners Holdings, LDC $ 2,000,000 13,245 13,245 -- Argent Classic Convertible Arbitrage Fund $13,500,000 89,403 89,403 -- (Bermuda) L.P. Associated Electric & Gas Insurance $ 370,000 2,450 2,450 -- Services Limited BNP Arbitrage SNC $10,000,000 66,225 66,225 -- C&H Sugar Company, Inc. $ 120,000 794 794 -- Coastal Convertibles Ltd. $ 400,000 2,649 2,649 -- Clinton Riverside convertible Portfolio $ 2,000,000 13,245 13,245 -- Limited CIBC World Markets $14,677,000 97,198 97,198 -- Deephaven Domestic Convertible Trading $ 6,500,000 43,046 43,046 -- Ltd. Delaware Public Employees' Retirement $ 750,000 4,966 4,966 -- System Deutsche Bank Securities, Inc. $29,670,000 196,490 196,490 -- Fidelity Financial Trust: Fidelity $ 3,640,000 24,105 24,105 -- Convertible Securities Fund First Republic Bank $ 100,000 662 662 -- Grace Brothers, Ltd. $ 2,000,000 13,245 13,245 -- Hawaiian Airlines Employees Pension $ 65,000 430 430 -- Plan-IAM Hawaiian Airlines Pension Plan for $ 15,000 99 99 -- Salaried Employees Hawaiian Airlines Pilots Retirement Plan $ 100,000 662 662 -- ICI American Holdings Trust $ 600,000 3,973 3,973 -- Island Holdings $ 75,000 496 496 -- Janus Capital Corporation $16,000,000 105,960 105,960 -- Lincoln National Convertible Securities $ 3,000,000 19,867 19,867 -- Fund Lipper Convertibles L.P. $ 4,000,000 26,490 26,490 -- Lord Abbett Bond Debenture Fund $ 3,000,000 19,867 19,867 -- 59 (1) Information concerning the selling security holders may change from time to time and any such changed information will be set forth in supplements to this prospectus if and when necessary. In addition, the per share conversion price, and therefore the number of shares issuable upon conversion of the notes, is subject to adjustment under certain circumstances. Accordingly, the aggregate principal amount of notes and the number of shares of common stock issuable upon conversion of the notes offered hereby may increase or decrease. (2) Assumes a conversion price of $151.00 per share, and a cash payment in lieu of any fractional share interest. 59
Principal Amount Number of Shares of of Notes Common Stock ---------------- --------------------------------------------- Beneficially Owned and Offered Beneficially Offered Owned After Selling Security Holder(1) Hereby(1) Owned(1)(2) Hereby the Offering - ------------------------------------------------------- ----------------- ------------ ------------- --------------- Museum of Fine Arts, Boston $ 26,000 172 172 -- Nalco Chemical Company $ 420,000 2,781 2,781 -- New Hampshire Retirement System $ 155,000 1,026 1,026 -- Parker-Hannifin Corporation $ 45,000 298 298 -- ProMutual $ 96,000 635 635 -- Putnam Asset Allocation Funds - Balanced $ 170,000 1,125 1,125 -- Portfolio Putnam Asset Allocation Funds - $ 112,000 741 741 -- Conservative Portfolio Putnam Balanced Retirement Fund $ 52,000 344 344 -- Putnam Convertible Income - Growth Trust $ 455,000 3,013 3,013 -- Putnam Convertible Opportunities and $ 69,000 456 456 -- Income Trust Queen's Health Plan $ 25,000 165 165 -- Rhone-Poulenc Rorer Pension Plan $ 33,000 218 218 -- Salomon Smith Barney, Inc. $ 1,150,000 7,615 7,615 -- SG Cowen Securities Corporation $ 3,000,000 19,867 19,867 -- Starvest Combined Portfolio $ 1,390,000 9,205 9,205 -- State of Oregon Equity $ 3,095,000 20,496 20,496 -- State of Oregon/SAIF Corporation $ 3,550,000 23,509 23,509 -- Sun America Equity Income Fund $ 15,000 99 99 -- Tribeca Investments L.L.C. $ 7,700,000 50,993 50,993 -- University of Rochester $ 25,000 165 165 -- Zeneca Holdings Pension Trust $ 500,000 3,311 3,311 -- Highbridge International LLC $ 7,115,000 47,119 47,119 -- ----------- ----------- ----------- ----------- Total: 150,000,000 1,001,953 993,353 8,600 =========== =========== =========== =========== 60 PLAN OF DISTRIBUTION The notes and common stock offered hereby may be sold from time to time to purchasers directly by the selling security holders. Alternatively, the selling security holders may from time to time offer the notes and common stock to or through underwriters, broker/dealers or agents, who may receive compensation in the form of underwriting discounts, concessions or commissions from the selling security holders or the purchasers of notes and common stock for whom they may act as agents. The selling security holders and any underwriters, broker/dealers or agents that participate in the distribution of notes and common stock may be deemed to be "underwriters" within the meaning of the Securities Act and any profit on the sale of notes and common stock by them and any discounts, commissions, concessions or other compensation received by any such underwriter, broker/dealer or agent may be deemed to be underwriting discounts and commissions under the Securities Act. The notes and common stock offered hereby may be sold from time to time in one or more transactions at fixed prices, at prevailing market prices at the time of sale, any varying prices determined at the time of sale or at negotiated prices. The sale of the notes and the common stock issuable upon conversion of the notes may be effected in transactions (which may involve crosses or block transactions) (i) on any national securities exchange or quotation service on which the notes or the common stock may be listed or quoted at the time of sale, (ii) in the over-the-counter market, (iii) in transactions otherwise than on such exchanges or in the over-the-counter market; or (iv) through the settlement of short sales. At the time a particular offering of the notes and the common stock is made, a prospectus supplement, if required, will be distributed that will set forth the aggregate amount and type of notes and common stock being offered and the terms of the offering, including the name or names of any underwriters, broker/dealers or agents, if any, any discounts, commissions and other terms constituting compensation from the selling security holders and any discounts, commissions or concessions allowed or reallowed or paid to broker/dealers. To comply with the securities laws of certain jurisdictions, if applicable, the notes and common stock will be offered or sold in such jurisdictions only through registered or licensed brokers or dealers. In addition, in certain jurisdictions the notes and common stock may not be offered or sold unless they have been registered or qualified for sale in such jurisdictions or an exemption from registration or qualification is available and is complied with. The selling security holders will be subject to applicable provisions of the Exchange Act and the rules and regulations thereunder, which provisions may limit the timing of purchases and sales of any of the notes and common stock by the selling security holders. The foregoing may affect the marketability of the notes and the common stock. Pursuant to the Registration Rights Agreement, all expenses of the registration of the notes and common stock will be paid by us, including, without limitation, Commission filing fees and expenses of compliance with state securities or "blue sky" laws; however, the selling security holders will pay all underwriting discounts and selling commissions, if any. The selling security holders will be indemnified by us against certain civil liabilities, including certain liabilities under the Securities Act, or will be entitled to contribution in connection therewith. 60 61 LEGAL MATTERS The legality of the notes is being passed upon by Graham James LLP, New York, New York. The legality of the common stock issuable on conversion of the notes is being passed upon by Gray Cary Ware & Freidenrich LLP, Palo Alto, California. EXPERTS The consolidated financial statements of PDL appearing in our Annual Report on Form 10-K for the year ended December 31, 1999, have been audited by Ernst & Young LLP, independent auditors, as set forth in their report thereon included therein and incorporated herein by reference. Such consolidated financial statements are incorporated herein by reference in reliance upon such report given upon the authority of such firm as experts in accounting and auditing. AVAILABLE INFORMATION We are subject to the informational requirements of the Securities Exchange Act of 1934, as amended (the Exchange Act), and in accordance therewith we file reports, proxy statements and other information with the Securities and Exchange Commission (the SEC). Such reports, proxy statements and other information can be inspected and copied at the public reference facilities maintained by the SEC at 450 Fifth Street, N.W., Room 1024, Washington, D.C. 20549-1004, and at the SEC's following Regional Offices: New York Regional Office, 7 World Trade Center, New York, New York 10048; and Chicago Regional Office, Citicorp Center, 500 West Madison Street, Suite 1400, Chicago, Illinois 60661-2511. Copies of such material may also be obtained at prescribed rates from the Public Reference Room of the SEC at 450 Fifth Street, N.W., Washington, D.C. 20549-1004. Information on the operation of the Public Reference Room can be obtained by calling the SEC at 1-800-SEC-0330. Our Common Stock is listed on the Nasdaq National Market and such reports and other information concerning us may also be inspected at the offices of The Nasdaq Stock Market, 1735 K Street, N.W., Washington DC 20006-1506. The SEC also maintains a web site at http://www.sec.gov that contains reports, proxy and other information statements and other information regarding registrants, including us, that file such information electronically with the SEC. We have also filed with the SEC a registration statement on Form S-3 (together with all amendments and exhibits thereto, the Registration Statement) under the Securities Act of 1933, as amended. This prospectus does not contain all the information set forth in the Registration Statement, certain parts of which are omitted in accordance with the rules and regulations of the Commission. For further information, reference is made to the Registration Statement, copies of which may be obtained from the Public Reference Section of the Commission, 450 Fifth Street, N.W., Washington DC 20549, upon payment of the fees prescribed by the Commission. INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE The following documents we filed with the SEC pursuant to the Exchange Act are incorporated herein by reference and made a part hereof: - Annual Report on Form 10-K for the year ended December 31, 1999 filed on March 30, 2000 61 62 - Current Reports on Form 8-K filed on February 14, 2000 and March 1, 2000, and - The description of our Common Stock which is contained in our Registration Statement on Form 8-A under the Exchange Act on December 23, 1991, including any amendment or reports filed for the purpose of updating such description. All documents and reports filed by us with the SEC pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of this prospectus and prior to the termination of this offering shall be deemed to be incorporated by reference into this prospectus and to be a part hereof from the date of filing of such documents. Any statement contained in a document incorporated herein by reference shall be deemed to be modified or superseded for purposes of this prospectus to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such earlier statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this prospectus. Upon written or oral request, we will provide without charge to each person to whom this prospectus is delivered, a copy of any or all documents incorporated by reference in this prospectus (other than any exhibits to those documents not specifically incorporated in those documents by reference). Requests for such documents should be submitted to Protein Design Labs, Inc., 34801 Campus Drive, Fremont, California 94555, Attention: Corporate Communications, or made by telephone at (510) 574-1400. LIMITATIONS OF LIABILITY AND INDEMNIFICATION MATTERS We have adopted provisions in our certificate of incorporation, which the Delaware General Corporation Law permits, that provide that our directors shall not be personally liable to us or our stockholders for monetary damages resulting from a violation of the directors' duty to act with care and in the best interests of the stockholders, except for liability: - for any breach of a director's duty of loyalty to us or our stockholders - for acts or omissions that are not in good faith, or involve intentional misconduct or a knowing violation of the law - under Section 174 of the Delaware General Corporation Law relating to improper dividends or distributions, and - for any transaction from which the director obtained an improper personal benefit. This limitation of liability does not affect the availability of equitable remedies, including injunctive relief or rescission. Our bylaws authorize us to indemnify our officers, directors, employees and agents to the fullest extent permitted by the Delaware General Corporation Law. Section 145 of the Delaware General Corporation Law empowers us to enter into indemnification agreements with our officers, directors, employees and agents. 62 63 We have entered into separate indemnification agreements with each of our current directors and executive officers which, in some cases, are broader than the specific indemnification provisions allowed by the Delaware General Corporation Law. The indemnification agreements require us to indemnify the executive officers and directors against liabilities that may arise by reason of status or service as directors or executive officers and to advance expenses they spend as a result of any proceeding against them for which they could be indemnified to the fullest extent permitted by the Delaware General Corporation Law. At present, there is no pending litigation or proceeding involving any of our directors, officers, employees or agents where indemnification will be required or permitted, and we are not aware of any threatened litigation or proceeding that may result in a claim for indemnification. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, executive officers or persons controlling us as described above, we have been informed that in the opinion of the SEC, such indemnification is against public policy as expressed in the Securities Act of 1933, as amended, and is therefore unenforceable. 63 64 ================================================================================ NO DEALER, SALESPERSON OR OTHER PERSON HAS BEEN AUTHORIZED TO GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS OTHER THAN THOSE CONTAINED OR INCORPORATED BY REFERENCE IN THIS PROSPECTUS IN CONNECTION WITH THE OFFERING DESCRIBED HEREIN, AND, IF GIVEN OR MADE, SUCH INFORMATION OR REPRESENTATION MUST NOT BE RELIED UPON AS HAVING BEEN AUTHORIZED BY PDL, ANY SELLING SECURITY HOLDER OR BY ANY UNDERWRITER. THIS PROSPECTUS DOES NOT CONSTITUTE AN OFFER TO SELL, OR A SOLICITATION OF AN OFFER TO BUY, ANY SECURITIES OTHER THAN THE REGISTERED SECURITIES TO WHICH IT RELATES, OR AN OFFER TO SELL, OR A SOLICITATION OF AN OFFER TO BUY, IN ANY JURISDICTION IN WHICH IT IS UNLAWFUL TO MAKE SUCH OFFER OR SOLICITATION. NEITHER THE DELIVERY OF THIS PROSPECTUS NOR ANY SALE MADE HEREUNDER SHALL, UNDER ANY CIRCUMSTANCES, CREATE AN IMPLICATION THAT THERE HAS BEEN NO CHANGE IN THE AFFAIRS OF PDL SINCE THE DATE HEREOF OR THAT THE INFORMATION CONTAINED HEREIN IS CORRECT AS OF ANY TIME SUBSEQUENT TO THE DATE HEREOF. TABLE OF CONTENTS PAGE Summary.......................................................................6 Selected Financial Data......................................................13 Risk Factors.................................................................15 Use of Proceeds..............................................................30 Price Range of Common Stock..................................................30 Dividend Policy..............................................................30 Description of Notes.........................................................31 Description of Capital Stock.................................................49 Certain Federal Income Tax Considerations...............................................................50 Selling Security Holders.....................................................57 Plan of Distribution.........................................................60 Legal Matters................................................................61 Experts......................................................................61 Available Information........................................................61 ================================================================================ ================================================================================ PROSPECTUS ------------------ $150,000,000 PROTEIN DESIGN LABS, INC. 5.50% CONVERTIBLE SUBORDINATED NOTES DUE 2007 May __, 2000 ------------------ ================================================================================ 65 PART II INFORMATION NOT REQUIRED IN PROSPECTUS ITEM 14. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION. The following table sets forth the fees and expenses in connection with the issuance and distribution of the securities being registered hereunder. Except for the SEC registration fee, all amounts are estimates. ITEM 15. INDEMNIFICATION OF DIRECTORS AND OFFICERS. Section 145 of the Delaware General Corporation Law ("DGCL") authorizes a court to award, or a corporation's board of directors to grant, indemnity to directors and officers under certain circumstances for liabilities incurred in connection with their activities in such capacities (including reimbursement for expenses incurred). The Registrant's Restated Certificate of Incorporation provides that the Registrant will indemnify its directors and officers to the fullest extent permitted by law and that directors shall not be liable for monetary damages to the Registrant or its stockholders for breach of fiduciary duty, except to the extent that the DGCL prohibits elimination or limitation of such liability. The Registrant's Restated Certificate of Incorporation provides that no director of the Registrant will be personally liable to the Registrant or its stockholders for monetary damages for breach of fiduciary duty as a director, except for liability (i) for any breach of the director's duty of loyalty to the Registrant or to its stockholders, (ii) for acts or omissions not made in good faith or involving intentional misconduct or a knowing violation of the law, (iii) under Section 174 of the DGCL, or (iv) for any transactions from which the director derives an improper personal benefit. In addition, the Registrant's Amended and Restated Bylaws provide that any director or officer who was or is a party or is threatened to be made a party to any action or proceeding by reason of his or her services to the Registrant will be indemnified to the fullest extent permitted by the DGCL. The Registrant has entered into agreements with each of its executive officers and directors under which the Registrant has agreed to indemnify each of them against expenses and losses incurred for claims brought against them by reason of their being an officer or director of the Registrant. There is no pending litigation or proceeding involving a director or officer of the Registrant as to which indemnification is being sought, nor is the Registrant aware of any pending or threatened litigation that may result in claims for indemnification by any director or executive officer. II-1
- ------------------------------------------------------------------------ SEC registration fee $ 39,600 - ------------------------------------------------------------------------ Accounting fees and expenses $ 10,000 - ------------------------------------------------------------------------ Legal fees and expenses $ 25,000 - ------------------------------------------------------------------------ Blue Sky fees and expenses (including counsel fees) $ 0 - ------------------------------------------------------------------------ Printing and engraving expenses $ 0 - ------------------------------------------------------------------------ Transfer agent's and registrar's fees and expenses $ 0 - ------------------------------------------------------------------------ Miscellaneous expenses, including Listing Fees $ 17,500 - ------------------------------------------------------------------------ $ 92,100 Total - ------------------------------------------------------------------------ 66 ITEM 16. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES. Exhibits: EXHIBIT NUMBER DESCRIPTION ------ ----------- 5.1 Opinion of Gray Cary Ware & Freidenrich LLP as to legality of shares 5.2 Opinion of Graham & James LLP as to legality of notes 10.33* Indenture between the Company and Chase Manhattan Bank And Trust Company, National Association, a national banking association, dated February 15, 2000 10.34* Registration Rights Agreement for the Company's 5.50% Convertible Subordinated Notes due February 15, 2007, between the Company and the Initial Purchasers dated February 15, 2000 12 Statements Regarding Computations of Ratios 23.1 Consent of Gray Cary Ware & Freidenrich LLP (contained in Exhibit 5.1) 23.2 Consent of Ernst & Young LLP, independent auditors 24 Power of Attorney (contained in the signature page hereof) 25 Statement of Eligibility of the Trustee on Form T-1 * Incorporated herein by reference from the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 1999 filed March 30, 2000. ITEM 17. UNDERTAKINGS. (a) The undersigned Registrant hereby undertakes: (1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement: (i) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933 ("Securities Act"). (ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of II-2 67 securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement. (iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement. Notwithstanding the foregoing, paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed by the registrant pursuant to Section 13 or Section 15(d) of the Securities and Exchange Act of 1934 that are incorporated by reference in the registration statement. (2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. (3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering. (b) The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. (c) Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue. II-3 68 (d) The undersigned registrant hereby undertakes to file an application for the purpose of determining the eligibility of the trustee to act under subsection (a) of Section 310 of the Trust Indenture Act ("TIA") in accordance with the rules and regulations prescribed by the commission under Section 305(b)(2) of the Act. II-4 69 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the County of Alameda, State of California on May 9, 2000. PROTEIN DESIGN LABS, INC. By: /s/ LAURENCE JAY KORN ---------------------------------------- Laurence Jay Korn Chief Executive Officer and Chairperson of the Board of Directors POWER OF ATTORNEY Each person whose signature appears below constitutes and appoints Laurence Jay Korn and Cary L. Queen, and each of them, with full power of substitution and resubstitution and each with full power to act without the other, his or her true and lawful attorney-in-fact and agent, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and all other documents in connection therewith, with the Securities and Exchange Commission or any state, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their, his or her substitutes or substitute, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated. Date: May 9, 2000 /s/ LAURENCE JAY KORN ----------------------------------------- Laurence Jay Korn Chief Executive Officer and Chairperson of the Board of Directors Date: May 9, 2000 /s/ ROBERT L. KIRKMAN ----------------------------------------- Robert L. Kirkman Vice President, Business Development and Corporation Communications (Principal Accounting Officer) 70 Date: May 9, 2000 /s/ JON S. SAXE ------------------------------------------ Jon S. Saxe Director Date: May 9, 2000 /s/ CARY L. QUEEN ------------------------------------------ Cary L. Queen Director Date: May 9, 2000 /s/ GEORGE M. GOULD ------------------------------------------ George M. Gould Director Date: May 9, 2000 /s/ MAX LINK ------------------------------------------ Max Link Director Date: May 9, 2000 /s/ JURGEN DREWS ------------------------------------------ Jurgen Drews Director 71 INDEX TO EXHIBITS
Exhibit No. ----------- 5.1 Opinion of Gray Cary Ware & Freidenrich LLP as to legality of shares 5.2 Opinion of Graham & James LLP as to legality of notes 10.33* Indenture between the Company and Chase Manhattan Bank And Trust Company, National Association, a national banking association, dated February 15, 2000 10.34* Registration Rights Agreement for the Company's 5.50% Convertible Subordinated Notes due February 15, 2007 between the Company and the Initial Purchasers, dated February 15, 2000 12 Statements Regarding Computations of Ratios 23.1 Consent of Gray Cary Ware & Freidenrich LLP (contained in Exhibit 5.1) 23.2 Consent of Ernst & Young LLP, independent auditors 24 Power of Attorney (contained in the signature page hereof) 25 Statement of Eligibility of the Trustee on Form T-1 * Incorporated herein by reference from the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 1999 filed March 30, 2000.
1 Exhibit 5.1 [GRAY CARY LETTERHEAD] May 9, 2000 Protein Design Labs, Inc. 34801 Campus Drive Fremont, California 94555 Re: PROTEIN DESIGN LABS, INC. REGISTRATION STATEMENT ON FORM S-3 Dear Ladies and Gentlemen: As counsel to Protein Design Labs, Inc., a Delaware corporation (the "Company"), we are rendering this opinion in connection with the registration by the Company pursuant to the above-referenced Registration Statement on Form S-3 (the "Registration Statement") under the Securities Act of 1933, as amended (the "Act"), of $150,000,000 aggregate principal amount of the Company's 5.50% Convertible Subordinated Notes due February 15, 2007 (the "Notes") and the common stock, par value $0.01 per share (the "Stock"), of the Company issuable upon conversion thereof. The Notes were issued pursuant to the Indenture (the "Indenture"), dated as of February 15, 2000, between the Company and Chase Manhattan Bank and Trust Company, National Association, as Trustee thereunder (the "Trustee"). As such counsel and in connection with the opinions expressed below, we have examined a copy of (a) the Registration Statement, (b) the Indenture, (c) a specimen of the Stock and (d) the originals, or copies identified to our satisfaction, of such corporate records of the Company, certificates of public officials, officers of the Company and other persons, and such other documents, agreements and instruments as we have deemed necessary as a basis for the opinions hereinafter expressed. In our examinations, we have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals and the conformity with the originals of all documents submitted to us as copies. In expressing the opinions set forth below, we have also relied on certain certificates of officers of the Company and certificates of public officials. Our opinions expressed below are limited to the laws of the State of California and the federal law of the United States, and we do not express any opinion herein concerning any other law. Based on such examination and review and subject to the foregoing, we are of the opinion that the shares of Stock initially issuable upon conversion of the Notes have been duly and validly authorized and reserved for issuance and, when issued and delivered in accordance with the provisions of the Notes and the Indenture, will be duly and validly issued and fully paid and non-assessable. 2 PROTEIN DESIGN LABS, INC. APRIL 28, 2000 PAGE TWO We hereby consent to the use of this opinion as an exhibit to the Registration Statement and to the reference to our firm under the caption "Legal Matters" therein. In giving this consent, we do not thereby agree that we come within the category of persons whose consent is required by the Act or the rules and regulations promulgated thereunder. Very truly yours, /s/ GRAY CARY WARE & FREIDENRICH LLP - ------------------------------------ Gray Cary Ware & Freidenrich LLP
1 EXHIBIT 5.2 [GRAHAM & JAMES LLP LETTERHEAD] April 20, 2000 Protein Design Labs, Inc. 34801 Campus Drive Fremont, California 94555 RE: PROTEIN DESIGN LABS CONVERTIBLE SUBORDINATED NOTE OFFERING Ladies and Gentlemen: We have acted as special New York counsel for Protein Design Labs, Inc., a Delaware corporation (the "Company"), in connection with the registration by the Company of 5.50% Convertible Subordinated Notes due February 15, 2007 (the "Notes") pursuant to a Registration Statement on Form S-3 (the "Registration Statement") under the Securities Act of 1933, as amended (the "Act"), and rules and regulations promulgated thereunder (the "Rules"). In connection with the opinion expressed herein, we have examined (i) the Registration Statement, (ii) the form of the Notes, and (iii) a final execution copy of the Indenture dated as of February 15, 2000 (the "Indenture") between the Company and Chase Manhattan Bank and Trust Company, National Association. In addition, we have assumed the due authorization, execution, authentication, issuance and delivery of the Notes. We have made no independent investigation of fact. We have made such investigations of law as we have deemed necessary. In providing the opinion hereafter set forth, we have also assumed the due authorization, execution and delivery of the Indenture by each party named therein (including the Company) and that the Indenture so executed and delivered is identical to the final execution copy delivered to us. In addition, we have assumed that the Indenture is enforceable against each of the parties thereto other than the Company. Based upon the foregoing and subject to the matters hereinafter set forth we are of the opinion that: (i) The Notes, insofar as they are governed by the laws of the State of New York, when duly authorized, executed, authenticated, issued and delivered in accordance with the provisions of the Indenture will constitute valid and legally binding obligations of the Company enforceable in accordance with their terms, except as enforcement thereof may be limited by bankruptcy, insolvency, reorganization, fraudulent transfer, moratorium and similar laws relating to or affecting enforcement of creditors rights or by the availability of equitable 2 April 20, 2000 Page 2 remedies. We are not admitted to practice in any jurisdiction other than the State of New York and do not purport to be expert on, and we are not expressing an opinion with respect to, laws other than the laws of the State of New York. This opinion is furnished for your benefit, and no other person or entity is entitled to rely on this opinion without our express written consent. This opinion may not be published or reproduced in any manner or distributed or circulated to any person or entity without our express written consent; provided, however, that we consent to the filing of this opinion as an exhibit to the Registration Statement and to the reference to our firm under the caption "Legal Matters" therein. In giving this consent, we do not thereby agree that we come within the category of persons whose consent is required by the Act or the Rules. This opinion is limited to the matters stated herein, and no opinion is implied or may be inferred beyond the matters expressly stated herein. This opinion speaks as of the date hereof, and we undertake no obligation to update this opinion after the date hereof. Very truly yours, /s/ GRAHAM & JAMES LLP - ---------------------------------------- Graham & James LLP
1 EXHIBIT 10.33 Indenture between the Company and Chase Manhattan Bank And Trust Company, National Association, a national banking association, dated February 15, 2000 (Incorporated herein by reference from the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 1999 filed March 30, 2000, and accompanied by its table of contents and the following cross-reference sheet) 2 TABLE OF CONTENTS
PAGE ARTICLE ONE DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION SECTION 1.1 Definitions..................................................................1 SECTION 1.2 Compliance Certificates and Opinions........................................12 SECTION 1.3 Form of Documents Delivered to the Trustee..................................13 SECTION 1.4 Acts of Holders of Securities...............................................13 SECTION 1.5 Notices, Etc., to Trustee and Company.......................................15 SECTION 1.6 Notice to Holders of Securities; Waiver.....................................16 SECTION 1.7 Effect of Headings and Table of Contents....................................16 SECTION 1.8 Successors and Assigns......................................................16 SECTION 1.9 Separability Clause.........................................................17 SECTION 1.10 Benefits of Indenture.......................................................17 SECTION 1.11 Governing Law...............................................................17 SECTION 1.12 Legal Holidays..............................................................17 SECTION 1.13 Conflict with Trust Indenture Act...........................................17 SECTION 1.14 Counterparts................................................................18 ARTICLE TWO THE SECURITIES SECTION 2.1 Form Generally..............................................................18 SECTION 2.2 Title and Terms.............................................................19 SECTION 2.3 Denominations...............................................................20 SECTION 2.4 Execution, Authentication, Delivery and Dating..............................20 SECTION 2.5 Global Securities; Non-Global Securities....................................20 SECTION 2.6 Registration, Registration of Transfer and Exchange; Restrictions on Transfer....................................................................22 SECTION 2.7 Mutilated, Destroyed, Lost or Stolen Securities.............................25 SECTION 2.8 Payment of Interest; Interest Rights Preserved..............................26 SECTION 2.9 Persons Deemed Owners.......................................................27 SECTION 2.10 Cancellation................................................................27 SECTION 2.11 Computation of Interest.....................................................27 SECTION 2.12 CUSIP Numbers...............................................................27 3
ARTICLE THREE SATISFACTION AND DISCHARGE SECTION 3.1 Satisfaction and Discharge of Indenture......................................28 SECTION 3.2 Application of Trust Money...................................................29 ARTICLE FOUR REMEDIES SECTION 4.1 Events of Default............................................................29 SECTION 4.2 Acceleration of Maturity; Rescission and Annulment...........................31 SECTION 4.3 Collection of Indebtedness and Suits for Enforcement by Trustee..............32 SECTION 4.4 Trustee May File Proofs of Claim.............................................33 SECTION 4.5 Trustee May Enforce Claims without Possession of Securities..................34 SECTION 4.6 Application of Money Collected...............................................34 SECTION 4.7 Limitation on Suits..........................................................34 SECTION 4.8 Unconditional Right of Holders to Receive Principal, Premium and Interest and to Convert...............................................35 SECTION 4.9 Restoration of Rights and Remedies...........................................35 SECTION 4.10 Rights and Remedies Cumulative...............................................35 SECTION 4.11 Delay or Omission Not Waiver.................................................36 SECTION 4.12 Control by Holders of Securities.............................................36 SECTION 4.13 Waiver of Past Defaults......................................................36 SECTION 4.14 Undertaking for Costs........................................................37 SECTION 4.15 Waiver of Stay, Usury or Extension Laws......................................37 ARTICLE FIVE THE TRUSTEE SECTION 5.1 Certain Duties and Responsibilities..........................................37 SECTION 5.2 Notice of Defaults...........................................................39 SECTION 5.3 Certain Rights of Trustee....................................................39 SECTION 5.4 Not Responsible for Recitals or Issuance of Securities.......................40 SECTION 5.5 May Hold Securities, Act as Trustee under Other Indentures...................41 SECTION 5.6 Money Held in Trust..........................................................41 SECTION 5.8 Corporate Trustee Required; Eligibility......................................42 SECTION 5.9 Resignation and Removal; Appointment of Successor............................42 SECTION 5.10 Acceptance of Appointment by Successor.......................................44 SECTION 5.11 Merger, Conversion, Consolidation or Succession to Business..................44 SECTION 5.12 Authenticating Agents........................................................44 4
SECTION 5.13 Disqualification; Conflicting Interests......................................46 SECTION 5.14 Preferential Collection of Claims against Company............................46 ARTICLE SIX CONSOLIDATION, MERGER, CONVEYANCE, TRANSFER OR LEASE SECTION 6.1 Company May Consolidate, Etc., Only on Certain Terms SECTION 6.2 Successor Substituted........................................................47 ARTICLE SEVEN SUPPLEMENTAL INDENTURES SECTION 7.1 Supplemental Indentures without Consent of Holders of Securities.............47 SECTION 7.2 Supplemental Indentures with Consent of Holders of Securities................48 SECTION 7.3 Execution of Supplemental Indentures.........................................49 SECTION 7.4 Effect of Supplemental Indentures............................................50 SECTION 7.5 Reference in Securities to Supplemental Indentures...........................50 SECTION 7.6 Notice of Supplemental Indentures............................................50 ARTICLE EIGHT COVENANTS SECTION 8.1 Payment of Principal, Premium and Interest...................................50 SECTION 8.2 Maintenance of Offices or Agencies...........................................51 SECTION 8.3 Money for Security Payments to Be Held in Trust..............................51 SECTION 8.4 Existence 52 SECTION 8.5 Maintenance of Properties....................................................53 SECTION 8.6 Payment of Taxes and Other Claims............................................53 SECTION 8.7 Registration and Listing.....................................................53 SECTION 8.8 Statement by Officers as to Default..........................................54 SECTION 8.9 Delivery of Certain Information..............................................54 SECTION 8.10 Resale of Certain Securities; Reporting Issuer...............................55 SECTION 8.11 Waiver of Certain Covenants..................................................55 5
ARTICLE NINE REDEMPTION OF SECURITIES SECTION 9.1 Right of Redemption..........................................................55 SECTION 9.2 Applicability of Article.....................................................55 SECTION 9.3 Election to Redeem; Notice to Trustee........................................55 SECTION 9.4 Selection by Trustee of Securities to Be Redeemed............................56 SECTION 9.5 Notice of Redemption.........................................................56 SECTION 9.6 Deposit of Redemption Price..................................................57 SECTION 9.7 Securities Payable on Redemption Date........................................57 SECTION 9.8 Securities Redeemed in Part..................................................58 SECTION 9.9 Conversion Arrangement on Call for Redemption................................58 ARTICLE TEN CONVERSION OF SECURITIES SECTION 10.1 Conversion Privilege and Conversion Rate.....................................59 SECTION 10.2 Exercise of Conversion Privilege.............................................59 SECTION 10.3 Fractions of Shares..........................................................61 SECTION 10.4 Adjustment of Conversion Rate................................................61 SECTION 10.5 Notice of Adjustments of Conversion Rate.....................................66 SECTION 10.6 Notice of Certain Corporate Action...........................................67 SECTION 10.7 Company to Reserve Common Stock..............................................68 SECTION 10.8 Taxes on Conversions.........................................................68 SECTION 10.9 Covenant as to Common Stock..................................................68 SECTION 10.10 Cancellation of Converted Securities.........................................68 SECTION 10.11 Provision in Case of Consolidation, Merger or Sale of Assets.................69 SECTION 10.12 Responsibility of Trustee for Conversion Provisions..........................70 ARTICLE ELEVEN SUBORDINATION OF SECURITIES SECTION 11.1 Securities Subordinate to Senior Debt........................................70 SECTION 11.2 No Payments in Certain Circumstances; Payment Over of Proceeds Upon Dissolution, Etc.....................................................70 SECTION 11.3 Trustee to Effectuate Subordination..........................................72 SECTION 11.4 No Waiver of Subordination Provisions........................................73 SECTION 11.5 Notice to Trustee............................................................73 SECTION 11.6 Reliance on Judicial Order or Certificate of Liquidating Agent...............74 SECTION 11.7 Trustee Not Fiduciary for Holders of Senior Debt.............................74 6
SECTION 11.8 Reliance by Holders of Senior Debt on Subordination Provisions...............74 SECTION 11.9 Rights of Trustee as Holder of Senior Debt; Preservation of Trustee's Rights..............................................................75 SECTION 11.10 Article Applicable to Paying Agents..........................................75 SECTION 11.11 Certain Conversions and Repurchases Deemed Payment...........................75 ARTICLE TWELVE REPURCHASE OF SECURITIES AT THE OPTION OF THE HOLDER UPON A CHANGE IN CONTROL SECTION 12.1 Right to Require Repurchase..................................................76 SECTION 12.2 Conditions to the Company's Election to Pay the Repurchase Price in Common Stock........................................................77 SECTION 12.3 Notices; Method of Exercising Repurchase Right, Etc..........................77 ARTICLE THIRTEEN HOLDERS LISTS AND REPORTS BY TRUSTEE AND COMPANY; NON-RECOURSE SECTION 13.1 Company to Furnish Trustee Names and Addresses of Holders....................80 SECTION 13.2 Preservation of Information..................................................81 SECTION 13.3 No Recourse against Others...................................................81 SECTION 13.4 Reports by Trustee...........................................................81 SECTION 13.5 Reports by Company...........................................................82 7 Certain Sections of the Indenture relating to Sections 310 through 318 of the Trust Indenture Act of 1989: -------------------------------------------------- TIA Indenture Section Section -------------------------------------------------- 310(a)(1) 5.8 -------------------------------------------------- (a)(2) 5.8 -------------------------------------------------- (a)(3) N/A -------------------------------------------------- (a)(4) N/A -------------------------------------------------- (a)(5) 5.8 -------------------------------------------------- (b) 5.13 -------------------------------------------------- (c) N/A -------------------------------------------------- 311(a) 5.14 -------------------------------------------------- (b) 5.14 -------------------------------------------------- (c) N/A -------------------------------------------------- 312(a) 13.1, 13.2 -------------------------------------------------- (b) 13.2(b) -------------------------------------------------- (c) 13.2(c) -------------------------------------------------- 313(a) 13.4 -------------------------------------------------- (b)(1) N/A -------------------------------------------------- (b)(2) 13.4 -------------------------------------------------- (c) 13.4 -------------------------------------------------- (d) 13.4 -------------------------------------------------- 314(a) 13.5 -------------------------------------------------- (b) N/A -------------------------------------------------- (c)(1) 1.2 -------------------------------------------------- (c)(2) 1.2 -------------------------------------------------- (c)(3) N/A -------------------------------------------------- (d) N/A -------------------------------------------------- (e) 1.2 -------------------------------------------------- (f) N/A -------------------------------------------------- 315(a) 5.1(a) -------------------------------------------------- (b) 5.2 -------------------------------------------------- (c) 5.1(b) -------------------------------------------------- (d) 5.1, 5.3 -------------------------------------------------- (e) 4.14 -------------------------------------------------- 316(a)(last sentence) 1.1, 5.1 -------------------------------------------------- (a)(1)(A) 4.12 -------------------------------------------------- (a)(1)(B) 4.13 -------------------------------------------------- (a)(2) N/A -------------------------------------------------- 8 -------------------------------------------------- TIA Indenture Section Section -------------------------------------------------- (b) 4.8 -------------------------------------------------- (c) 1.4(e) -------------------------------------------------- 317(a)(1) 4.3 -------------------------------------------------- (a)(2) 4.4 -------------------------------------------------- (b) 8.3 -------------------------------------------------- 318(a) 1.13 -------------------------------------------------- - ---------------------- N/A means Not Applicable Note: This Cross-Reference Table shall not, for any purpose, be deemed as part of the Indenture
1 EXHIBIT 12. Statement Regarding Computations of Ratios RATIO OF EARNINGS TO FIXED CHARGES (in thousands) (1) For the purposes of computing the ratio of earnings to fixed charges, earnings consist of income (loss) before provision for income taxes plus fixed charges. Fixed charges consist of interest charges, amortization of debt expense and discount or premium related to indebtedness, whether expensed or capitalized, and that portion of rental payments under operating leases we believe to be representative of interest. (2) Earnings for the years ended December 31, 1995, 1996, 1997, 1998 and 1999, were insufficient to cover fixed charges by $8,354, $11,796, $23,875, $9,502, and $10,333, respectively (in thousands).
YEAR ENDED DECEMBER 31, ------------------------------------------------------ 1995 1996 1997 1998 1999 ------- -------- -------- ------- -------- FIXED CHARGES(1): Interest charges $ 1 $ -- $ -- $ -- $ 155 Interest portion of rental expense 472 485 563 788 894 ------- -------- -------- ------- -------- Total Fixed Charges $ 473 $ 485 $ 563 $ 788 $ 1,049 EARNINGS(1): Net loss $(8,354) $(11,796) $(23,875) $(9,502) $(10,333) Plus fixed charges 473 485 563 788 1,049 ------- -------- -------- ------- -------- Total Earnings $(7,881) $(11,311) $(23,312) $(8,714) $ (9,284) RATIO OF EARNINGS TO FIXED CHARGES(2) -- -- -- -- --
1 EXHIBIT 23.2 Consent of Ernst & Young LLP We consent to the reference to our firm under the caption "Experts" in the Registration Statement (Form S-3) and related Prospectus of Protein Design Labs, Inc. for the registration of $150,000,000 principal amount of 5.5% Convertible Subordinated Notes Due February 15, 2007 and the 993,377 shares of Common Stock issuable upon conversion of the Notes and to the incorporation by reference therein of our report dated February 1, 2000 with respect to the consolidated financial statements of Protein Design Lab, Inc. included in its Annual Report on Form 10-K for the year ended December 31, 1999, filed with the Securities and Exchange Commission. /S/ ERNST & YOUNG LLP Palo Alto, California May 9, 2000
1 EXHIBIT NO. 25 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 --------------------------- FORM T-1 Statement of Eligibility and Qualification Under the Trust Indenture Act of 1939 of a Corporation Designated to Act as Trustee ----------------------- CHECK IF AN APPLICATION TO DETERMINE ELIGIBILITY OF A TRUSTEE PURSUANT TO SECTION 305(B)(2)____ ------------------------- CHASE MANHATTAN BANK AND TRUST COMPANY, NATIONAL ASSOCIATION (Exact name of trustee as specified in its charter) 95-4655078 (I.R.S. Employer Identification No.) 101 California Street, San Francisco, California (Address of principal executive offices) 94111 (Zip Code) ------------------ PROTEIN DESIGN LABS, INCORPORATED (Exact name of Obligor as specified in its charter) Delaware (State or other jurisdiction of incorporation or organization) 94-3023969 (I.R.S. Employer Identification No.) 34801 Campus Drive Fremont, CA (Address of principal executive offices) 94555 (Zip Code) -------------------------------- 5.50% Convertible Subordinated Notes Due February 15, 2007 (Title of Indenture securities) 2 ITEM 1. GENERAL INFORMATION. Furnish the following information as to the trustee: (a) Name and address of each examining or supervising authority to which it is subject. Comptroller of the Currency, Washington, D.C. Board of Governors of the Federal Reserve System, Washington, D.C. (b) Whether it is authorized to exercise corporate trust powers. Yes. ITEM 2. AFFILIATIONS WITH OBLIGOR. If the Obligor is an affiliate of the trustee, describe each such affiliation. None. ITEM 4. TRUSTEESHIPS UNDER OTHER INDENTURES. None. ITEM 16. LIST OF EXHIBITS. List below all exhibits filed as part of this statement of eligibility. Exhibit 1. Articles of Association of the Trustee as Now in Effect (see Exhibit 1 to Form T-1 filed in connection with Registration Statement No. 333-41329, which is incorporated by reference). Exhibit 2. Certificate of Authority of the Trustee to Commence Business (see Exhibit 2 to Form T-1 filed in connection with Registration Statement No. 333-41329, which is incorporated by reference). Exhibit 3. Authorization of the Trustee to Exercise Corporate Trust Powers (contained in Exhibit 2). Exhibit 4. Existing By-Laws of the Trustee (see Exhibit 4 to Form T-1 filed in connection with Registration Statement No. 333-41329, which is incorporated by reference). Exhibit 5. Not Applicable Exhibit 6. The consent of the Trustee required by Section 321 (b) of the Act (see Exhibit 6 to Form T-1 filed in connection with Registration Statement No. 333-41329, which is incorporated by reference). Exhibit 7. A copy of the latest report of condition of the Trustee, published pursuant to law or the requirements of its supervising or examining authority. Exhibit 8. Not Applicable Exhibit 9. Not Applicable 3 SIGNATURE Pursuant to the requirements of the Trust Indenture Act of 1939, the Trustee, Chase Manhattan Bank and Trust Company, National Association, has duly caused this statement of eligibility and qualification to be signed on its behalf by the undersigned, thereunto duly authorized, all in the City of San Francisco, and State of California, on the 24th day of March, 2000. CHASE MANHATTAN BANK AND TRUST COMPANY, NATIONAL ASSOCIATION By /s/ James V. Myers --------------------------------- James V. Myers Vice President 4
EXHIBIT 7. Report of Condition of the Trustee. - ---------------------------------------------------------------------------------------- CONSOLIDATED REPORT OF CONDITION OF Chase Manhattan Bank and Trust Company, N.A. ---------------------------------------------------- (Legal Title) LOCATED AT 1800 Century Park East, Ste. 400 Los Angeles, CA 94111 ----------------------------------------------------------------------------- (Street) (City) (State) (Zip) AS OF CLOSE OF BUSINESS ON December 31, 1999 ------------------- ========================================================================================= ========================================================================================= ASSETS DOLLAR AMOUNTS IN THOUSANDS 1. Cash and balances due from a. Noninterest-bearing balances and currency and coin(1,2) 4,258 b. Interest bearing balances(3) 0 2. Securities a. Held-to-maturity securities (from Schedule RC-B, column A) 0 b. Available-for-sale securities (from Schedule RC-B, column D) 1,089 3. Federal Funds sold (4) and securities purchased agreements to resell 82,900 4. Loans and lease financing receivables: a. Loans and leases, net of unearned income (from Schedule RC-C) 68 b. LESS: Allowance for loan and lease losses 0 c. LESS: Allocated transfer risk reserve 0 d. Loans and leases, net of unearned income, allowance, and reserve (item 4.a minus 4.b and 4.c) 68 5. Trading assets 0 6. Premises and fixed assets (including capitalized leases) 142 7. Other real estate owned (from Schedule RC-M) 0 8. Investments in unconsolidated subsidiaries and associated companies (from Schedule RC-M) 0 9. Customers liability to this bank on acceptances outstanding 0 10. Intangible assets (from Schedule RC-M) 1,026 11. Other assets (from Schedule RC-F) 1,996 12a. TOTAL ASSETS 91,479 (1) includes cash items in process of collection and unposted debits. (2) The amount reported in this item must be greater than or equal to the sum of Schedule RC-M, items 3.a and 3.b (3) includes time certificates of deposit not held for trading. 5 (4) Report "term federal funds sold" in Schedule RC, item 4.a "Loans and leases, net of unearned income" and in Schedule RC-C, part 1. 6
LIABILITIES 13. Deposits: a. In domestic offices (sum of totals of columns A and C from Schedule RC-E) 59,457 (1) Noninterest-bearing 7,509 (2) Interest-bearing 51,948 b. In foreign offices, Edge and Agreement subsidiaries, and IBF (1) Noninterest-bearing (2) Interest-bearing 14. Federal funds purchased (2) and securities sold under agreements to repurchase 0 15. a. Demand notes issued to the U.S. Treasury 0 b. Trading liabilities 0 16. Other borrowed money (includes mortgage indebtedness and obligations under capitalized leases): a. With a remaining maturity of one year or less 0 b. With a remaining maturity of more than one year through three years 0 c. With a remaining maturity of more than three years 0 17. Not applicable 18. Bank's liability on acceptances executed and outstanding 0 19. Subordinated notes and Debentures(3) 0 20. Other liabilities (from Schedule RC-G) 5,756 21. Total liabilities (sum of items 13 through 20) 65,213 22. Not applicable EQUITY CAPITAL 23. Perpetual preferred stock and related surplus 0 24. Common stock-- 600 25. Surplus (exclude all surplus related to preferred stock) 12,590 26. a. Undivided profits and capital reserves 13,076 b. Net unrealized holding gains (losses) on available-for-sale securities 0 27. Cumulative foreign currency translation adjustments 28. a. Total equity capital (sum of items 23 through 27) 26,266 29. Total liabilities, equity capital, and losses deferred pursuant to 12 U.S.C. 1823 (j) (sum of items 21 and 28.c) 91,479