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                            UNITED STATES              -------------------------
                  SECURITIES AND EXCHANGE COMMISSION       OMB APPROVAL
                        Washington, D.C. 20549         -------------------------
                                                       OMB Number 3235-0145
                                                       Expires: October 31, 1994
                                                       Estimated average burden
                                                       -------------------------
                                 SCHEDULE 13G
                                       
                                       
                                       
                   UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (Amendment No. 5)
                                            
                                       
                                       
                           PROTEIN DESIGN LABS, INC.
                   -----------------------------------------
                               (Name of Issuer)
                                       
                                       
                                       
                                       
                         Common Stock, $0.01 Par Value
                   -----------------------------------------
                        (Title of Class of Securities)
                                       
                                       
                                       
                                       
                                  74369L-10-3
                   -----------------------------------------
                                (CUSIP Number)
                                       




     Check the following box if a fee is being paid with this statement  / /. 
(A fee is not required only if the filing person: (1) has a previous statement
on file reporting beneficial ownership of more than five percent of the class
of securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such class.)
(See Rule 13d-7).

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).


SEC 1745 (2/92)                Page 1 of 4 pages
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CUSIP NO. 74369L-10-3              SCHEDULE 13G        PAGE   2   OF   4  PAGES
         ---------------------                              -----    -----      

  (1)     NAME OF REPORTING PERSON                 
          S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON                

          Laurence Jay Korn          
          ---------------------------------------------------------------------

  (2)     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*     (a)  [   ]
                                                                (b)  [ X ] (A)

          --------------------------------------------------------------------- 

  (3)     SEC USE ONLY

          ---------------------------------------------------------------------

  (4)     CITIZENSHIP OR PLACE OF ORGANIZATION                      

          United States of America
          ---------------------------------------------------------------------

                       (5)     SOLE VOTING POWER                    
  NUMBER OF                    893,965(A)
   SHARES              --------------------------------------------------------
 BENEFICIALLY          (6)     SHARED VOTING POWER                  
  OWNED BY                     0
    EACH               --------------------------------------------------------
  REPORTING            (7)     SOLE DISPOSITIVE POWER               
 PERSON WITH                   893,965(A)
                       --------------------------------------------------------
                       (8)     SHARED DISPOSITIVE POWER             
                               734,150(A)
                       --------------------------------------------------------

  (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON         
                               893,965
          ---------------------------------------------------------------------

 (10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 9 EXCLUDES CERTAIN
          SHARES*                                                     [X]  (A)

          ---------------------------------------------------------------------

 (11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9           
                               4.9%
          ---------------------------------------------------------------------

 (12)     TYPE OF REPORTING PERSON*
                               IN
          ---------------------------------------------------------------------
          (A) See Item 4

                   *  SEE INSTRUCTIONS BEFORE FILLING OUT!



                          PAGE   2   OF   4   PAGES
                               -----    -----      
   3
                                                        Page  3   of  4   Pages
                                                            -----   -----

Item 1(a).   Name of Issuer:

                 Protein Design Labs, Inc.
                                        
Item 1(b).   Address of Issuer's Principal Executive Offices:    

                 2375 Garcia Avenue                           
                 Mountain View, CA 94043                    

Item 2(a)   Name of Person Filing:

                 Laurence Jay Korn 

Item 2(b)   Address of Principal Business Office or, if none, Residence:

                 Protein Design Labs
                 2375 Garcia Avenue
                 Mountain View, CA 94043

Item 2(c)   Citizenship:

                 The filing person is a citizen of the United States of America

Item 2(d)   Title of Class of Securities:

                 Common Stock, $.01 par value

Item 2(e)   CUSIP Number: 

                 74369L-10-3

Item 3.     Type of Person:

                 Not Applicable

Item 4.  Ownership (at December 31, 1997):

      (a)   Amount owned "beneficially" within the meaning of rule 13d-3:
            893,965 shares; includes 233,333 shares which are subject to
            purchase within 60 days pursuant to the exercise of stock options.
            Does not include 6,667 shares held as the separate property of the
            spouse of the reporting person. Reporting person disclaims
            beneficial ownership of such 6,667 shares. See also Item 4(c).

      (b)   Percent of Class: 4.9%, based on the total number of shares
            outstanding on December 31, 1997.

      (c)   Number of shares as to which such person has:

            (i)   sole power to vote or to direct the vote: 893,965 shares
                                                                       
            (ii)  shared power to vote or to direct the vote: None(1)
                                                                       
            (iii) sole power to dispose or to direct the disposition of:
                  893,965 shares
                                                                       
            (iv)  shared power to dispose or to direct the disposition of:
                  734,150(1)(2)

       (1) Does not include 6,667 shares held as the separate property of the
           spouse of the reporting person, with respect to which reporting 
           person disclaims beneficial ownership.

       (2) Reporting person shares the power to dispose or to direct the
           disposition of 734,150 shares owned beneficially by Dr. Cary L.
           Queen, a separate reporting person. Dr. Queen specifies in advance
           from time to time the number of shares over which reporting person
           will have the power to direct the disposition of. Reporting person
           disclaims beneficial ownership of the shares owned beneficially by
           Dr. Queen.
                                                                       

Item 5. Ownership of Five Percent or Less of a Class:

                 Not Applicable
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                                                        Page  4   of  4   Pages
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Item 6.  Ownership of More than Five Percent on Behalf of Another Person:

                Not Applicable

Item 7.  Identification and Classification of the Subsidiary Which Acquired 
         the Security Being Reported on by the Parent Holding Company:

                Not Applicable


Item 8.  Identification and Classification of Members of the Group:

                See Item 4(c)(iv), Note (2).
  


Item 9.  Notice of Dissolution of Group:

                Not Applicable


Item 10. Certification: Not Applicable




                                   SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct based on information as of December 31, 1997.

Date: 1-31-98                           /s/ LAURENCE JAY KORN
      -------                           ---------------------