UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION

                            Washington, D.C.  20549

                                 SCHEDULE 13G

                   Under the Securities Exchange Act of 1934

                              (Amendment No.    )


NAME OF ISSUER:  PDL BIOPHARMA INC.

TITLE OF CLASS OF SECURITIES:  Common

CUSIP NUMBER:  69329Y104

Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

	[X]	Rule 13d-1(b)
	[ ]	Rule 13d-1(c)
	[ ]	Rule 13d-1(d)

CUSIP NO.  69329Y104

(1)   Names of Reporting Persons            MELLON FINANCIAL CORPORATION
      SS or IRS Identification Nos. Of Above Person   IRS No. 25-1233834

(2)   Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)   (        ) (b)  (        )

(3)   SEC use only

(4)   Citizenship or Place of Organization                  Pennsylvania

Number of Shares             (5)  Sole Voting Power             5,159,452
Beneficially
Owned by Each                (6)  Shared Voting Power 		   88,605
Reporting Person
With                         (7)  Sole Dispositive Power        5,845,584

                             (8)  Shared Dispositive Power         14,550

(9)   Aggregate Amount Beneficially Owned by Each Reporting Person  5,876,325

(10)  Check if the Aggregate Amount in Row (9) Excludes Certain
      Shares (see Instructions)                                (        )

(11)  Percent of Class Represented by Amount in Row (9) 	5.09%

(12)  Type of Reporting Person (See Instructions)              HC



                                   UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C.  20549

                                   SCHEDULE 13G
                  (Under the Securities and Exchange Act of 1934)

Item 1(a)  Name of Issuer:  PDL BIOPHARMA INC.

Item 1(b)  Address of Issuer's Principal Executive Offices:
                                        	34801 CAMPUS DR.
						FREMONT, CA 94555

Item 2(a)  Name of Person Filing:  Mellon Financial Corporation and any other
                                   reporting person(s) identified on the
                                   second part of the cover page(s) and
     				   Exhibit I.

Item 2(b)  Address of Principal Business Office, or if None, Residence:
                                             c/o Mellon Financial Corporation
                                             One Mellon Center
                                             Pittsburgh, Pennsylvania 15258
                                             (for all reporting persons)

Item 2(c)  Citizenship:                      See cover page and Exhibit I.

Item 2(d)  Title of Class of Securities:     Common

Item 2(e)  CUSIP Number:  69329Y104

Item 3     See Item 12 of cover page(s) ("Type of Reporting
           Person") for each reporting person.

               BK = Bank as defined in Section 3(a)(6) of the Act

               IV = Investment Company registered under Section 8 of the
                    Investment Company Act of 1940

               IA = Investment Advisor registered under Section 203 of the
                    Investment Advisors Act of 1940

               EP = Employee Benefit Plan, Pension Fund which is subject to
                    the provisions of the Employee Retirement Income
                    Security Act of 1974 or Endowment Fund; see
                    Section 240.13-d(1)(b)(1)(ii)(F)

               HC = Parent Holding Company, in accordance with Section
                    240.13-d(1)(b)(1)(ii)(G)

Item 4  Ownership:  See Item 5 through 9 and 11 of cover page(s)
                    as to each reporting person.

The amount beneficially owned includes, where appropriate, securities
not outstanding which are subject to options, warrants, rights or
conversion privileges that are exercisable within 60 days. The securities
reported herein as beneficially owned may exclude securities of the issuer
with respect to which voting and/or dispositive power is exercised by
subsidiaries of Mellon Financial Corporation, or departments or units
thereof, independently from the exercise of those powers over the
securities reported herein.  See SEC Release No. 34-39538(January 12, 1998).
The filing of this Schedule 13G shall not be construed as an admission
that Mellon Financial Corporation, or its direct or indirect subsidiaries,
including Mellon Bank, N.A., are for the purposes of Section 13(d) or 13(g)
of the Act, the beneficial owners of any securities covered by this
Schedule 13G.

The following information applies if checked: (     ) Mellon Bank, N.A. is the
trustee of the issuer's employee benefit plan (the "Plan"), which is subject to
ERISA. The securities reported include all shares held of record by Mellon Bank,
N.A. as trustee of the Plan which have not been allocated to the individual
accounts of employee participants in the Plan.  The reporting person, however,
disclaims beneficial ownership of all shares that have been allocated to the
individual accounts of employee participants in the Plan for which directions
have been received and followed.

Item 5  Ownership of Five Percent or Less of a Class:  If this
statement is being filed to report the fact that as of the date hereof
the reporting person has ceased to be the beneficial owner of more
than five percent of the class of securities, check the following (  )

Item 6  Ownership of More than Five Percent on Behalf of Another
Person:  All of the securities are beneficially owned by Mellon Financial
Corporation and direct or indirect subsidiaries in their various
fiduciary capacities.  As a result, another entity in every instance
is entitled to dividends or proceeds of sale.  The number of
individual accounts holding an interest of 5% or more is (  )

Item 7  Identification and Classification of the Subsidiary Which Acquired
        the Security Being Reported by the Parent Holding Company:
        See Exhibit I.

Item 8  Identification and Classification of Members of the Group:     N/A

Item 9  Notice of Dissolution of Group:                                N/A



Item 10 Certification:  By signing below I certify that, to the best of
my knowledge and belief, the securities referred to above were acquired and
are held in the ordinary course of business and were not acquired and are
not held for the purpose of and do not have the effect of changing or
influencing the control of the issuer of such securities and were not
acquired and are not held in connection with or as a participant in
any transaction having such purpose or effect.


SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true,
complete and correct.  This filing is signed by Mellon Financial
Corporation on behalf of all reporting entities pursuant to Rule
13d-1(f)(1) promulgated under the Securities and Exchange Act of 1934,
as amended.

Date:  February 12, 2007

MELLON FINANCIAL CORPORATION

By:  /s/ DAVID BELSTERLING
    --------------------------
      David Belsterling
      First Vice President
      Mellon Bank, N.A.
      Attorney-In-Fact for
      Mellon Financial Corporation


				EXHIBIT I

The shares reported on the attached Schedule 13G are beneficially owned by the
following direct or indirect subsidiaries of Mellon Financial Corporation, as
marked (X):

(A)	The Item 3 classification of each of the subsidiaries listed below is
	Item 3(b) Bank as defined in Section 3(a)(6) of the Act.

	(X)  Mellon Bank, N.A. (parent holding company of MMIP, LLC; Mellon Trust
             of Delaware, National Association)
	(X)  Mellon Trust of New England, National Association (parent holding
	     company of Equity (DE) Trust 1 and Equity (DE) Trust 2)
	( )  Mellon Private Trust Company, National Association
	(X)  Mellon Trust of California
	(X)  Mellon Trust of Delaware, National Association
	( )  Mellon Trust of New York, LLC
	(X)  Mellon Trust of Washington

(B)	The Item 3 classification of each of the subsidiaries listed below is
	"Item 3(e) Investment Advisor registered under Section 203 of the
	Investment Advisors Act of 1940."

	( )  Boston Safe Advisors, Inc.
	(X)  The Dreyfus Corporation (parent holding company of Dreyfus Service
	     Corporation)
	(X)  Dreyfus Service Corporation (parent holding company Founders Asset
	     Management LLC)
	( )  Founders Asset Management LLC
	(X)  Franklin Portfolio Associates LLC
	( )  Laurel Capital Advisors, LLP
	(X)  Mellon Capital Management Corporation
	(X)  Mellon Equity Associates, LLP
	( )  Mellon Global Investments Limited
	( )  Mellon Hedge Advisors, LLC
	( )  Newton Capital Management Limited
	(X)  Newton Investment Management Limited
	(X)  Standish Mellon Asset Management Company LLC
	(X)  The Boston Company Asset Management, LLC
	( )  Walter Scott & Partners Limited

(C)	The Item 3 classification of each of the legal entities listed below is
	"Item 3(g) Parent Holding Company, in accordance with
	Section 240.13d-I(b)(ii)(G)."

	(X)  Mellon Financial Corporation
	(X)  MMIP, LLC (parent holding company to Laurel Capital Advisors, LLP;
	     Mellon Equity Associates, LLP)
	(X)  The Boston Company, Inc. (parent holding company of Mellon Private
	     Trust Company, National Association; Mellon Trust of California;
	     Mellon Trust of New York, LLC; Mellon Trust of Washington)
	( )  Equity (MA) Trust (parent holding company of Boston Safe Advisors,
	     Inc.; Mellon Hedge Advisors, LLC)
	( )  Equity (DE) Trust 1 and Equity (DE) Trust 2 (parent holding companies
	     of Equity (MA) Trust)
	(X)  Newton Management Limited (parent holding company of Newton Capital
             Management Limited; Newton Investment Management Limited)
	(X)  Mellon International Limited (parent holding company of Newton Management
             Limited; Walter Scott & Partners Limited)
	(X)  Neptune LLC (parent holding company of Mellon International Limited)
	(X)  MBC Investments Corporation (parent holding company of Mellon Capital
	     Management Corporation; Neptune LLC)
	(X)  Fixed Income (MA) Trust (parent holding company of Franklin Portfolio
	     Associates, LLC; The Boston Company Asset Management, LLC; Standish
	     Mellon Asset Management Company LLC)
	(X)  Fixed Income (DE) Trust (parent holding company of Fixed Income(MA) Trust)


NOTE:  ALL OF THE LEGAL ENTITIES LISTED UNDER (A) AND (B) ABOVE ARE DIRECT OR
INDIRECT SUBSIDIARIES OF MELLON FINANCIAL CORPORATION.  BENEFICIAL OWNERSHIP OF
MORE THAN FIVE PERCENT OF THE CLASS BY ANY ONE OF THE SUBSIDIARIES OR
INTERMEDIATE PARENT HOLDING COMPANIES LISTED ABOVE IS REPORTED ON A JOINT
REPORTING PERSON PAGE FOR THAT SUBSIDIARY ON THE ATTACHED SCHEDULE 13G AND IS
INCORPORATED IN THE TOTAL PERCENT OF CLASS REPORTED ON MELLON FINANCIAL
CORPORATION'S REPORTING PERSON PAGE. (DO NOT ADD THE SHARES OR PERCENT OF CLASS
REPORTED ON EACH JOINT REPORTING PERSON PAGE ON THE ATTACHED SCHEDULE 13G TO
DETERMINE THE TOTAL PERCENT OF CLASS FOR MELLON FINANCIAL CORPORATION).