UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                               (Amendment No. __)*


                            PROTEIN DESIGN LABS, INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                          Common Stock, $0.01 Par Value
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    74369L103
                            -------------------------
                                 (CUSIP Number)


                                  March 6, 1998
                     --------------------------------------
                      (Date of Event which Requires Filing
                               of this Statement)



Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                                [ ] Rule 13d-1(b)
                                [X] Rule 13d-1(c)
                                [ ] Rule 13d-1(d)



  *The remainder of this cover page shall be filled out for a reporting person's
  initial filing on this form with respect to the subject class of securities,
  and for any subsequent amendment containing information which would alter the
  disclosures provided in a prior cover page.

  The information required on the remainder of this cover page shall not be
  deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
  Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
  the Act but shall be subject to all other provisions of the Act (however, see
  the Notes).






CUSIP No.  74369L103                  13G                


      1  NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Soros Fund Management LLC

      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                    (a) [ ]
                                                    (b) [x]

      3  SEC USE ONLY

      4  CITIZENSHIP OR PLACE OF ORGANIZATION

         DELAWARE

                     5  SOLE VOTING POWER

                        963,700

   NUMBER OF         6  SHARED VOTING POWER
     SHARES
  BENEFICIALLY          -0-
    OWNED BY
      EACH           7  SOLE DISPOSITIVE POWER
   REPORTING
     PERSON             963,700
      WITH

                     8  SHARED DISPOSITIVE POWER

                        -0-

      9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         963,700

     10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                        [X]


     11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         5.29%

     12  TYPE OF REPORTING PERSON*

         OO, IA

                      *SEE INSTRUCTION BEFORE FILLING OUT!




                                        2




CUSIP No.  74369L103                  13G                


      1  NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         George Soros  (in the capacity described herein)

      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                   (a) [ ]
                                                   (b) [x]

      3  SEC USE ONLY


      4  CITIZENSHIP OR PLACE OF ORGANIZATION

         UNITED STATES

                     5  SOLE VOTING POWER

                        -0-

    NUMBER OF        6  SHARED VOTING POWER
     SHARES
  BENEFICIALLY          963,700
    OWNED BY
      EACH           7  SOLE DISPOSITIVE POWER
   REPORTING
     PERSON             -0-
      WITH

                     8  SHARED DISPOSITIVE POWER

                        963,700

      9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         963,700

     10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES*                            [X]


     11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         5.29%

     12  TYPE OF REPORTING PERSON*

         IA



                      *SEE INSTRUCTION BEFORE FILLING OUT!



                                        3




CUSIP No.  74369L103                  13G                


      1  NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Stanley F. Druckenmiller (in the capacity described herein)

      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                        (a) [ ]
                                                        (b) [x]

      3  SEC USE ONLY


      4  CITIZENSHIP OR PLACE OF ORGANIZATION

         UNITED STATES

                     5  SOLE VOTING POWER

                        350,100

   NUMBER OF         6  SHARED VOTING POWER
     SHARES
  BENEFICIALLY          963,700
    OWNED BY
      EACH           7  SOLE DISPOSITIVE POWER
   REPORTING
     PERSON             350,100
      WITH
                     8  SHARED DISPOSITIVE POWER

                        963,700

      9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         1,313,800

     10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES*                        [ ]

     11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         7.21%

     12  TYPE OF REPORTING PERSON*

         IA


                      *SEE INSTRUCTION BEFORE FILLING OUT!



                                        4




CUSIP No.  74369L103                  13G                 


      1  NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Duquesne Capital Management, L.L.C.

      2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                     (a) [ ]
                                                     (b) [x]

      3  SEC USE ONLY


      4  CITIZENSHIP OR PLACE OF ORGANIZATION

         PENNSYLVANIA

                     5  SOLE VOTING POWER

                        350,100

   NUMBER OF         6  SHARED VOTING POWER
     SHARES
  BENEFICIALLY          -0-
    OWNED BY
      EACH           7  SOLE DISPOSITIVE POWER
   REPORTING
     PERSON             350,100
      WITH

                     8  SHARED DISPOSITIVE POWER

                        -0-

      9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         350,100

     10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES*                        [X]


     11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         1.92%

     12  TYPE OF REPORTING PERSON*

         OO, IA


                      *SEE INSTRUCTION BEFORE FILLING OUT!



                                        5



Item 1(a)             Name of Issuer:
                      --------------

                      Protein Design Labs, Inc. (the "Issuer")

Item 1(b)             Address of Issuer's Principal Executive Offices:
                      -----------------------------------------------

                      2375 Garcia Avenue
                      Mountain View, California 94043

Items 2(a)            Name of Person Filing:
                      ---------------------

                      This Statement is filed on behalf of the following persons
                      (collectively, the "Reporting Persons"):

                      i)   Soros Fund Management LLC, a Delaware 
                           limited liability company ("SFM LLC");   
                                                               
                      ii)  Mr. George Soros ("Mr. Soros");

                      iii) Mr. Stanley F. Druckenmiller ("Mr. Druckenmiller");
                           and
                      
                      iv)  Duquesne Capital Management, L.L.C., a   
                           Pennsylvania limited liability company    
                           ("Duquesne LLC").                         
                           
                      This Statement relates to Shares (as defined herein) held
                      for the accounts of Quantum Partners and the Duquesne LLC
                      Clients (each as defined herein). SFM LLC, a Delaware
                      limited liability company, serves as principal investment
                      manager to Quantum Partners LDC, a Cayman Islands exempted
                      duration company ("Quantum Partners") and, as such, has
                      been granted investment discretion over portfolio
                      investments, including the Shares, held for the account of
                      Quantum Partners. Mr. Soros is the Chairman of SFM LLC.
                      Mr. Druckenmiller is the Lead Portfolio Manager and a
                      Member of the Management Committee of SFM LLC. Mr.
                      Druckenmiller also owns a 75% interest in, and is the sole
                      managing member of, Duquesne LLC, an investment advisory
                      firm that serves as a discretionary investment advisor to
                      a limited number of institutional clients (the "Duquesne
                      LLC Clients").
                           


                                        6




Item 2(b)             Address of Principal Business Office:
                      ------------------------------------

                      The address of the principal business office of each of
                      SFM LLC, Mr. Soros and Mr. Druckenmiller is 888 Seventh
                      Avenue, 33rd Floor, New York, NY 10106.

                      The address of the principal business office of Duquesne
                      LLC is 2579 Washington Road, Suite 322, Pittsburgh,
                      Pennsylvania 15241-2591.

Item 2(c)             Citizenship:
                      -----------

                      i)    SFM LLC is a Delaware limited liability company;

                      ii)   Mr. Soros is a United States citizen;

                      iii)  Mr. Druckenmiller is a United States citizen; and

                      iv)   Duquesne LLC is a Pennsylvania limited liability 
                            company.

Item 2(d)             Title of Class of Securities:
                      ----------------------------

                      Common Stock, par value $0.01 per share (the "Shares")

Item 2(e)             CUSIP Number:
                      ------------

                      74369L103

Item 3                Not Applicable

Item 4.               Ownership:
                      ---------

Item 4(a)             Amount Beneficially Owned:
                      -------------------------

                      As of March 5, 1998, each of the Reporting Persons may be
                      deemed the beneficial owner of the following number of
                      Shares:

                      i) SFM LLC and Mr. Soros and may be deemed to be the
                      beneficial owner of the 963,700 Shares held for the
                      account of Quantum Partners.

                      ii) Mr. Druckenmiller may be deemed the beneficial owner
                      of 1,313,800 Shares. This number consists of (A) 963,700
                      Shares held for the account of Quantum Partners and (B)
                      350,100 Shares held for the accounts of the Duquesne LLC
                      Clients.


                                        7



                       
                      iii) Duquesne LLC may be deemed the beneficial owner of
                      the 350,100 Shares held for the accounts of the Duquesne
                      LLC Clients.


Item 4(b)             Percent of Class:
                      ----------------

                      i) The number of Shares of which SFM LLC and Mr. Soros may
                      be deemed to be the beneficial owner constitutes
                      approximately 5.29% of the total number of Shares
                      outstanding.

                      ii) The number of Shares of which Mr. Druckenmiller may be
                      deemed to be the beneficial owner constitutes
                      approximately 7.21% of the total number of Shares
                      outstanding.

                      iii) The number of Shares of which Duquesne LLC may be
                      deemed to be the beneficial owner constitutes
                      approximately 1.92% the total number of Shares
                      outstanding.


Item 4(c)             Number of shares as to which such person has:
                      --------------------------------------------

                      SFM LLC
                      -------

                      (i)   Sole power to vote or to direct the vote:
                            963,700

                      (ii)  Shared power to vote or to direct the vote: -0-

                      (iii) Sole power to dispose or to direct the disposition
                            of: 963,700

                      (iv)  Shared power to dispose or to direct the disposition
                            of: -0-

                      Mr. Soros
                      ---------

                      (i)   Sole power to vote or to direct the vote: -0-

                      (ii)  Shared power to vote or to direct the vote: 963,700

                      (iii) Sole power to dispose or to direct the disposition
                            of: -0-

                      (iv)  Shared power to dispose or to direct the
                            disposition of: 963,700


                                        8



                              
                      Mr. Druckenmiller
                      -----------------

                      (i)   Sole power to vote or to direct the vote: 350,100

                      (ii)  Shared power to vote or to direct the vote: 963,700

                      (iii) Sole power to dispose or to direct the disposition
                            of: 350,100

                      (iv)  Shared power to dispose or to direct the disposition
                            of: 963,700

                      Duquesne LLC
                      ------------

                      (i)   Sole power to vote or to direct the vote: 350,100

                      (ii)  Shared power to vote or to direct the vote: -0-

                      (iii) Sole power to dispose or to direct the disposition
                            of: 350,100

                      (iv)  Shared power to dispose or to direct the disposition
                            of: -0-

Item 5                Ownership of Five Percent or Less of a Class:
                      -------------------------------------------- 

                      Not Applicable

Item 6                Ownership of More than Five Percent on Behalf of Another
                      Person:
                      -------------------------------------------------------- 

                      The shareholders of Quantum Partners, including Quantum
                      Fund N.V., a Netherlands Antilles company, have the right
                      to participate in the receipt of dividends from, or
                      proceeds from the sale of, the Shares held for the account
                      of Quantum Partners in accordance with their ownership
                      interests in Quantum Partners.

                      The Duquesne LLC Clients have the right to participate in
                      the receipt of dividends from, or proceeds from the sale
                      of, the Shares, held for their accounts.

                      Each of SFM LLC and Mr. Soros expressly disclaims
                      beneficial ownership of any Shares held for the accounts
                      of the Duquesne LLC Clients. Duquesne LLC expressly
                      disclaims beneficial ownership of any Shares held for the
                      account of Quantum Partners.


                                        9

                            

Item 7                Identification and Classification of the
                      Subsidiary Which Acquired the Security Being
                      Reported on By the Parent Holding Company:
                      -------------------------------------------- 

                      Not Applicable

Item 8                Identification and Classification of Members of the  
                      Group:
                      ---------------------------------------------------

                      Not Applicable


Item 9                Notice of Dissolution of Group:
                      ------------------------------ 

                      Not Applicable

Item 10               Certification:
                      -------------

    By signing below each signatory certifies that, to the best of his/its
knowledge and belief, the securities referred to above were not acquired and are
not held for the purpose of or with the effect of changing or influencing the
control of the Issuer of the securities and were not acquired and are not held
in connection with or as a participant in any transaction having that purpose or
effect.


                                       10



                                    SIGNATURE
                                    ---------

    After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.



Dated: March 6, 1998         SOROS FUND MANAGEMENT LLC


                             By: /s/  Michael C. Neus
                                --------------------------------
                                   Michael C. Neus
                                   Assistant General Counsel


Dated: March 6, 1998         GEORGE SOROS


                             By: /s/  Michael C. Neus
                                -------------------------------
                                   Michael C. Neus
                                   Attorney-in-Fact


Dated: March 6, 1998         STANLEY F. DRUCKENMILLER


                             By: /s/  Michael C. Neus
                                -------------------------------
                                   Michael C. Neus
                                   Attorney-in-Fact


Dated: March 6, 1998         DUQUESNE CAPITAL MANAGEMENT, L.L.C.


                             By: /s/  Gerald Kerner
                                -------------------------------
                                    Gerald Kerner
                                    Managing Director



                                       11



                                  EXHIBIT INDEX
                                  -------------

Exhibit No.           Description                               
- -----------           -----------                               


A.      Power of Attorney dated as of January 1, 1997
        granted by Mr. George Soros in favor of Mr. Sean
        Warren and Mr. Michael Neus.

B.      Power of Attorney dated as of January 1, 1997
        granted by Mr. Stanley F. Druckenmiller in favor
        of Mr. Sean Warren and Mr. Michael Neus. 

C.      Joint Filing Agreement dated March 6, 1998
        by and among Soros Fund Management LLC, Mr. George
        Soros and Mr. Stanley F. Druckenmiller and Duquesne
        Capital Management, L.L.C.  


















                                    EXHIBIT A
                                POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENTS, that I, GEORGE SOROS, hereby make, constitute
and appoint each of SEAN C. WARREN and MICHAEL C. NEUS, acting individually, as
my agent and attorney-in-fact for the purpose of executing in my name, (a) in my
personal capacity or (b) in my capacity as Chairman of, member of or in other
capacities with Soros Fund Management LLC, all documents, certificates,
instruments, statements, filings and agreements ("documents") to be filed with
or delivered to any foreign or domestic or governmental or regulatory body or
required or requested by any other person or entity pursuant to any legal or
regulatory requirement relating to the acquisition, ownership, management or
disposition of securities or other investments, and any other documents relating
or ancillary thereto, including but not limited to, all documents relating to
filings with the United States Securities and Exchange Commission (the "SEC")
pursuant to the Securities Act of 1933 or the Securities Exchange Act of 1934
(the "Act") and the rules and regulations promulgated thereunder, including: (1)
all documents relating to the beneficial ownership of securities required to be
filed with the Sec pursuant to Section 13(d) or Section 16(a) of the Act,
including, without limitation: (a) any acquisition statements on Schedule 13D or
Schedule 13G and any amendments thereto, (b) any joint filing agreements
pursuant to Rule 13d-1(f) and (c) any initial statements of, or statements of
changes in, beneficial ownership of securities on Form 3, Form 4 or Form 5 and
(2) any information statements on Form 13F required to be filed with the SEC
pursuant to Section 13(f) of the Act.

All past acts of the attorney-in-fact in furtherance of the foregoing are hereby
ratified and confirmed.

This power of attorney shall be valid from the date hereof until revoked by me.

IN WITNESS WHEREOF, I have executed this instrument as of the 1st day of
January, 1997.

                                /s/ George Soros
                                ----------------------------------------
                                GEORGE SOROS





                             








                                    EXHIBIT B
                                POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENTS, that I, STANLEY F. DRUCKENMILLER, hereby make,
constitute and appoint each of SEAN C. WARREN and MICHAEL C. NEUS, acting
individually, as my agent and attorney-in-fact for the purpose of executing in
my name, (a) in my personal capacity or (b) in my capacity as Lead Portfolio
Manager of, member of or in other capacities with Soros Fund Management LLC, all
documents, certificates, instruments, statements, filings and agreements
("documents") to be filed with or delivered to any foreign or domestic or
governmental or regulatory body or required or requested by any other person or
entity pursuant to any legal or regulatory requirement relating to the
acquisition, ownership, management or disposition of securities or other
investments, and any other documents relating or ancillary thereto, including
but not limited to, all documents relating to filings with the United States
Securities and Exchange Commission (the "SEC") pursuant to the Securities Act of
1933 or the Securities Exchange Act of 1934 (the "Act") and the rules and
regulations promulgated thereunder, including: (1) all documents relating to the
beneficial ownership of securities required to be filed with the Sec pursuant to
Section 13(d) or Section 16(a) of the Act, including, without limitation: (a)
any acquisition statements on Schedule 13D or Schedule 13G and any amendments
thereto, (b) any joint filing agreements pursuant to Rule 13d-1(f) and (c) any
initial statements of, or statements of changes in, beneficial ownership of
securities on Form 3, Form 4 or Form 5 and (2) any information statements on
Form 13F required to be filed with the SEC pursuant to Section 13(f) of the Act.

All past acts of the attorney-in-fact in furtherance of the foregoing are hereby
ratified and confirmed.

This power of attorney shall be valid from the date hereof until revoked by me.

IN WITNESS WHEREOF, I have executed this instrument as of the 1st day of
January, 1997.



                                /s/ Stanley F. Druckenmiller
                                -------------------------------------
                                STANLEY F. DRUCKENMILLER







                              



                                    EXHIBIT C

                             JOINT FILING AGREEMENT

    The undersigned hereby agree that the statement on Schedule 13G with respect
to the Common Stock of Protein Design Labs, Inc., dated as of March 6, 1998 is,
and any amendments thereto (including amendments on Schedule 13D) signed by each
of the undersigned shall be, filed on behalf of us pursuant to and in accordance
with the provisions of Rule 13d-1(f) under the Securities Exchange Act of 1934.


Dated: March 6, 1998         SOROS FUND MANAGEMENT LLC


                             By: /s/  Michael C. Neus
                                -------------------------------
                                  Michael C. Neus
                                  Assistant General Counsel


Dated: March 6, 1998         GEORGE SOROS


                             By: /s/  Michael C. Neus
                                -------------------------------
                                  Michael C. Neus
                                  Attorney-in-Fact


Dated: March 6, 1998         STANLEY F. DRUCKENMILLER


                             By: /s/  Michael C. Neus
                                -------------------------------
                                  Michael C. Neus
                                  Attorney-in-Fact


Dated: March 6, 1998         DUQUESNE CAPITAL MANAGEMENT, L.L.C.


                             By: /s/  Gerald Kerner
                                -------------------------------
                                  Gerald Kerner
                                  Managing Director