SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 10-Q

       (Mark One)

       [X]    Quarterly report pursuant to Section 13 or 15(d) of the Securities
              Exchange Act of 1934

       For the Quarterly Period Ended September 30, 1998

                                       OR

       [ ]    Transition report pursuant to Section 13 or 15(d) of the
              Securities Exchange Act of 1934

                         Commission File Number: 0-19756

                            PROTEIN DESIGN LABS, INC.
             (Exact name of registrant as specified in its charter)

                   Delaware                               94-3023969
        (State or other jurisdiction of                (I.R.S. Employer
        incorporation or organization)              Identification Number)


                               34801 Campus Drive
                               Fremont, Ca. 94555
                    (Address of principal executive offices)
                         Telephone Number (510) 574-1400

       Indicate by check mark whether the registrant (1) has filed all reports
       required to be filed by Section 13 or 15(d) of the Securities Exchange
       Act of 1934 during the preceding 12 months (or for such shorter period
       that the registrant was required to file such reports) and, (2) has been
       subject to such filing requirements for the past 90 days:

                          Yes [X]              No [ ]


     As of September 30, 1998, there were 18,554,572 shares of the Registrant's
     Common Stock outstanding.










PROTEIN DESIGN LABS, INC.


INDEX


PART I. FINANCIAL INFORMATION




ITEM 1.  FINANCIAL STATEMENTS   

Statements of Operations
Three months ended September 30, 1998 and 1997   
Nine months ended September 30, 1998 and 1997

Balance Sheets
September 30, 1998 and December 31, 1997        

Statements of Cash Flows
Nine months ended September 30, 1998 and 1997   

Notes to Unaudited Financial Statements 


ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF        
         FINANCIAL CONDITION AND RESULTS OF OPERATIONS    



PART II. OTHER INFORMATION

ITEM 5.  OTHER INFORMATION - RISK FACTORS      

ITEM 6.  EXHIBITS AND REPORTS ON FORM 8-K       

Signatures              


















                          PART I. FINANCIAL INFORMATION

ITEM 1.  FINANCIAL STATEMENTS
                            PROTEIN DESIGN LABS, INC.
                            STATEMENTS OF OPERATIONS
(In thousands, except net loss per share data)
                                   (unaudited)
Three Months Ended Nine Months Ended September 30, September 30, --------------------- --------------------- 1998 1997 1998 1997 ---------- ---------- ---------- ---------- Revenues: Revenue under agreements with third parties $9,610 $4,550 $17,274 $9,341 Interest and other income 2,268 2,485 7,198 6,608 ---------- ---------- ---------- ---------- Total revenues 11,878 7,035 24,472 15,949 Costs and expenses: Research and development 8,949 6,311 22,683 19,124 General and administrative 2,240 1,629 6,040 4,651 ---------- ---------- ---------- ---------- Total costs and expenses 11,189 7,940 28,723 23,775 ---------- ---------- ---------- ---------- Net income / (loss) $689 ($905) ($4,251) ($7,826) ========== ========== ========== ========== Net income / (loss) per share: Basic $0.04 ($0.05) ($0.23) ($0.45) Diluted $0.04 ($0.05) ($0.23) ($0.45) ========== ========== ========== ========== Weighted average number of shares: Basic 18,545 18,170 18,506 17,433 Diluted 18,845 18,170 18,506 17,433 ========== ========== ========== ==========
See accompanying notes PROTEIN DESIGN LABS, INC. BALANCE SHEETS (In thousands, except par value per share)
September 30,December 31, 1998 1997 ------------ ---------- (unaudited) ASSETS Current assets: Cash and cash equivalents $44,740 $9,266 Short-term investments 78,106 63,003 Other current assets 9,808 779 ------------ ---------- Total current assets 132,654 73,048 Property and equipment, net 22,169 9,996 Long-term investments 22,946 91,386 Other assets 710 596 ------------ ---------- $178,479 $175,026 ============ ========== LIABILITIES AND STOCKHOLDERS' EQUITY Current liabilities: Accounts payable $1,175 $475 Accrued compensation 962 833 Accrued clinical trials 1,126 1,434 Other accrued liabilities 4,899 2,212 Deferred revenue 2,729 1,604 ------------ ---------- Total current liabilities 10,891 6,558 Commitments Stockholders' equity: Preferred stock, par value $0.01 per share, 10,000 shares authorized; no shares issued and outstanding -- -- Common stock, par value $0.01 per share, 40,000 shares authorized; 18,555 and 18,348 issued and outstanding at September 30, 1998 and December 31, 1997, respectively 186 183 Additional paid-in capital 230,425 227,093 Accumulated deficit (63,633) (59,382) Unrealized gain on investments 610 574 ------------ ---------- Total stockholders' equity 167,588 168,468 ------------ ---------- $178,479 $175,026 ============ ==========
See accompanying notes PROTEIN DESIGN LABS, INC. STATEMENTS OF CASH FLOWS INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS (unaudited) (In thousands)
Nine Months Ended September 30, ---------------------- 1998 1997 ---------- ---------- Cash flows from operating activities: Net loss ($4,251) ($7,826) Adjustments to reconcile net loss to net cash used in operating activities: Depreciation and amortization 2,595 2,392 Other 735 (879) Changes in assets and liabilities: Other current assets (9,028) (476) Accounts payable 700 (538) Accrued liabilities 2,508 (356) Deferred revenue 1,125 -- ---------- ---------- Total adjustments (1,365) 143 ---------- ---------- Net cash used in operating activities (5,616) (7,683) Cash flows from investing activities: Purchases of short- and long-term investments (92,320) (230,723) Maturities of short- and long-term investments 145,000 192,758 Capital expenditures (14,810) (2,646) Increase in other assets (114) (213) ---------- ---------- Net cash provided by (used in) investing activities 37,756 (40,824) Cash flows from financing activities: Proceeds from issuance of capital stock 3,334 71,332 ---------- ---------- Net cash provided by financing activities 3,334 71,332 ---------- ---------- Net increase in cash and cash equivalents 35,474 22,825 Cash and cash equivalents at beginning of period 9,266 14,141 ---------- ---------- Cash and cash equivalents at end of period $44,740 $36,966 ========== ==========
See accompanying notes PROTEIN DESIGN LABS, INC. NOTES TO FINANCIAL STATEMENTS September 30, 1998 (unaudited) Summary of Significant Accounting Policies Organization and Business Since the Company's founding in 1986, a primary focus of its operations has been research and development. Achievement of successful research and development and commercialization of products derived from such efforts is subject to high levels of risk and significant resource commitments. The Company has a history of operating losses and expects to incur substantial additional expenses over at least the next few years as it continues to develop its proprietary products, devote significant resources to preclinical studies, clinical trials, and manufacturing and to defend its patents and other proprietary rights. The Company's revenues to date have consisted principally of research and development funding, licensing and signing fees and milestone payments from pharmaceutical and biotechnology companies under collaborative research and development, humanization, patent licensing and clinical supply agreements. These revenues may vary considerably from quarter to quarter and from year to year, and revenues in any period may not be predictive of revenues in any subsequent period, and variations may be significant depending on the terms of the particular agreements. In 1998, the Company began receiving royalties from sales of Zenapax[R]. Royalties on sales of Zenapax are payable under exclusive license agreements with Hoffmann-La Roche Inc. and affiliates ("Roche"). The Company has also entered into non-exclusive licensing arrangements for other products recently approved for marketing. The Company is dependent upon the further development, regulatory and marketing efforts of its licensees and there can be no assurance that the development, regulatory and marketing efforts of its licensees will be successful, including, without limitation, if and when regulatory approvals in various countries may be obtained and whether or how quickly products might be adopted by the medical community. In addition, the Company recognizes royalty revenues when royalty reports are received from Roche and the Company's other licensees. This method of recognizing royalty revenues from the Company's licensees, taken together with the unpredictable timing of payments of non-recurring licensing and signing fees and milestones under new and existing collaborative research and development, humanization, patent licensing and clinical supply agreements, may result in significant fluctuations in revenues in quarterly and annual periods. Although the Company anticipates entering into new collaborations from time to time, the Company presently does not anticipate continuing to realize non-royalty revenue from its new and proposed collaborations at levels commensurate with the revenue historically recognized under its older collaborations. Moreover, the Company anticipates that it will incur significant operating expenses as the Company increases its research and development, manufacturing, preclinical, clinical, marketing and administrative and patent activities. Accordingly, in the absence of substantial revenues from new corporate collaborations or patent licensing arrangements, royalties on sales of products licensed under the Company's intellectual property rights or other sources, the Company anticipates that its operating expenses will continue to increase significantly as the Company increases its research and development, manufacturing, preclinical and clinical activity, and administrative and patent activities. Accordingly, in the absence of substantial revenues from new corporate collaborations or patent licensing agreements, significant royalties on sales of Zenapax and other products licensed under the Company's intellectual property rights, or other sources, the Company expects to incur substantial operating losses in the foreseeable future as certain of its earlier stage potential products move into later stage clinical development, as additional potential products are selected as clinical candidates for further development, as the Company invests in additional facilities or manufacturing capacity, as the Company defends or prosecutes its patents and patent applications and as the Company invests in research or acquires additional technologies, product candidates or businesses. Basis of Presentation and Responsibility for Quarterly Financial Statements The balance sheet as of September 30, 1998 and the statements of operations for the three month and nine periods and cash flows for the nine month periods ended September 30, 1998 and 1997 are unaudited but include all adjustments (consisting of normal recurring adjustments) which the Company considers necessary for a fair presentation of the financial position at such dates and the operating results and cash flows for those periods. Although the Company believes that the disclosures in these financial statements are adequate to make the information presented not misleading, certain information and footnote information normally included in financial statements prepared in accordance with generally accepted accounting principles have been condensed or omitted pursuant to the rules and regulations of the Securities and Exchange Commission. The accompanying financial statements should be read in conjunction with the Company's Annual Report on Form 10-K, filed with the Securities and Exchange Commission for the year ended December 31, 1997. Results for any quarterly period are not necessarily indicative of results for any other quarterly period or for the entire year. Cash Equivalents, Investments and Concentration of Credit Risk The Company considers all highly liquid investments purchased with a maturity of three months or less at the date of acquisition to be cash equivalents. The "Other" adjustments line item in the Statements of Cash Flows represents the accretion of the book value of certain debt securities. The Company places its cash and short-term and long- term investments with high-credit-quality financial institutions and in securities of the U.S. government and U.S. government agencies and, by policy, limits the amount of credit exposure in any one financial instrument. To date, the Company has not experienced credit losses on investments in these instruments. Cash and cash equivalents for the period ended September 30, 1998 increased primarily as a result of maturities of short-term and redemption of certain long-term investments. The changes in short- and long-term investments were the result of certain long-term investments reaching maturities of one year or less. Revenue Recognition Contract revenues from research and development are recorded as earned based on the performance requirements of the contracts. Revenues from achievement of milestone events are recognized when the funding party agrees that the scientific, clinical or regulatory results stipulated in the agreement have been met. Revenue recognized under certain clinical supply agreements is based upon the percentage of completion method. Deferred revenue arises principally due to the timing of cash payments received under research and development contracts. The Company's collaborative, humanization and patent licensing agreements with third parties provide for the payment of royalties to the Company based on net sales of licensed products under the agreements. Royalties, as reported to the Company, may include deductions for creditable amounts related to third party royalties as well as milestone payments, certain patent expense reimbursements and maintenance fees previously received by the Company. The agreements generally provide for royalty reports to the Company following completion of each calendar quarter or semi-annual period and royalty revenue is recognized when royalty reports are received from the third party. New Accounting Standards Effective as of January 1, 1998, the Company adopted Financial Accounting Standards Board Statement No. 130, "Reporting Comprehensive Income" ("FAS 130"). FAS 130 establishes new rules for the reporting and display of comprehensive income (loss) and its components; however, the adoption of FAS 130 had no impact on the Company's net loss or stockholders' equity. FAS 130 requires unrealized gains and losses on the Company's available-for-sale securities, which prior to adoption were reported separately in stockholders' equity, to be included in other comprehensive income (loss). FAS 130 permits the disclosure of this information in notes to interim financial statements and the Company has elected this approach. For the three month periods ended September 30, 1998 and 1997, total comprehensive income (loss) amounted to $0.9 million and ($0.6) million, respectively. For the nine month periods ended September 30, 1998 and 1997, total comprehensive loss amounted to $4.2 million and $7.3 million, respectively. Effective December 31, 1997, the Company adopted Financial Accounting Standards Board Statement No. 128, "Earnings Per Share" ("FAS 128"). FAS 128 requires the presentation of basic earnings (loss) per share and diluted earnings (loss) per share for all periods presented. In accordance with FAS 128, basic earnings (loss) per share have been computed using the weighted average number of shares of common stock outstanding during the periods presented and excluded the dilutive effect of stock options. If the Company had a net loss position for the applicable period, as is the case for the three month period ended September 30, 1997 and the nine month periods ended September 30, 1998 and 1997, FAS 128 specifies that the Company shall not include the effect of stock options outstanding for the applicable period as the effect would be antidilutive. Following is a reconciliation of the numerators and denominators of the basic and diluted earnings (loss) per share computations for the periods presented below: (In thousands, except net income / loss per share)
Three Months Ended Nine Months Ended September 30, September 30, --------------------- --------------------- 1998 1997 1998 1997 ---------- ---------- ---------- ---------- Numerator: Net income / (loss) $689 $(905) $(4,251) $(7,826) ========== ========== ========== ========== Denominator: Basic earnings / (loss) per share - weighted-average shares 18,545 18,170 18,506 17,433 Dilutive potential common shares: Stock Options 300 -- -- -- ---------- ---------- ---------- ---------- Denominator for diluted earnings/ (loss) per share 18,845 18,170 18,506 17,433 ========== ========== ========== ========== Basic net income / (loss) per share $0.04 $(0.05) $(0.23) $(0.45) ========== ========== ========== ========== Diluted net income / (loss) per share $0.04 $(0.05) $(0.23) $(0.45) ========== ========== ========== ==========
Management Estimates The preparation of financial statements in conformity with generally accepted accounting principles requires the use of management's estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. For example, the Company has a policy of recording expenses for clinical trials based upon pro rating estimated total costs of a clinical trial over the estimated length of the clinical trial and the number of patients anticipated to be enrolled in the trial. Expenses related to each patient are recognized ratably beginning upon entry into the trial and over the course of the trial. In the event of early termination of a clinical trial, management accrues an amount based on its estimate of the remaining non-cancellable obligations associated with the winding down of the clinical trial. These estimates and assumptions could differ significantly from the amounts which may actually be realized. In 1997, Boehringer Mannheim GmbH ("Boehringer Mannheim") invoked the dispute resolution provisions under its collaborative research agreement to address the reimbursement of up to $2.0 million for the Phase II study of OST 577 for the treatment of chronic hepatitis B ("CHB") then being conducted by Boehringer Mannheim as well as certain legal expenses related to Boehringer Mannheim's participation in the Company's public offering in the first quarter of 1997. In March 1998, Roche acquired Corange Limited, the parent company of Boehringer Mannheim. The Company is unable to predict the outcome of this proceeding but in any event has estimated and recorded a liability with respect to this matter. The collaborative research agreement with Boehringer Mannheim provides for reimbursement from PDL of costs and expenses of up to $2.0 million for a Phase II study of OST 577 in the event certain conditions were met with respect to that study. In June 1997, the Company entered into a Sponsored Research Agreement with Stanford University to provide aggregate funding and equipment support of up to $3.4 million over a period of 3 years for the laboratory of Stanley Falkow, Ph.D., Distinguished Investigator (consultant) of the Company. Dr. Falkow resigned as a member of the Board of Directors in September 1998 in connection with his assuming a more extensive role with the Company in certain ongoing research programs. The funding arrangement provides the Company with certain exclusive rights to intellectual property resulting from the research efforts in Dr. Falkow's laboratory during the funding period. The Company expensed approximately $0.5 and $0.2 million in connection with this funding arrangement for the nine month periods ended September 30, 1998 and 1997, respectively. Other Current Assets Other current assets increased for the period ended September 30, 1998 primarily as a result of an accounts receivable of $6.0 million for a nonrefundable licensing and signing fee received in October 1998. Property and Equipment Property and equipment increased for the period ended September 30, 1998 primarily as a result of capital expenditures related to the Company's new Fremont, California facilities. Other Accrued Liabilities Other accrued liabilities increased for the period ended September 30, 1998 primarily as a result of accruals of approximately $1.0 million each for (i) a signing and licensing fee paid in October 1998, and (ii) capital expenditures related to the Company's new Fremont, California facilities. ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS This Quarterly Report contains forward-looking statements which involve risks and uncertainties. The Company's actual results may differ significantly from the results discussed in the forward-looking statements. Factors that might cause such a difference include, but are not limited to those discussed in "Risk Factors" as well as those discussed elsewhere in this document and the Company's Annual Report on Form 10-K, filed with the Securities and Exchange Commission for the year ended December 31, 1997. OVERVIEW Since the Company's founding in 1986, a primary focus of its operations has been research and development. Achievement of successful research and development and commercialization of products derived from such efforts is subject to high levels of risk and significant resource commitments. The Company has a history of operating losses and expects to incur substantial additional expenses over at least the next few years as it continues to develop its proprietary products, devote significant resources to preclinical studies, clinical trials, and manufacturing and to defend its patents and other proprietary rights. The Company's revenues to date have consisted principally of research and development funding, licensing and signing fees and milestone payments from pharmaceutical and biotechnology companies under collaborative research and development, humanization, patent licensing and clinical supply agreements. These revenues may vary considerably from quarter to quarter and from year to year, and revenues in any period may not be predictive of revenues in any subsequent period, and variations may be significant depending on the terms of the particular agreements. In 1998, the Company began receiving royalties from sales of Zenapax. Royalties on sales of Zenapax are payable under exclusive license agreements with Hoffmann-La Roche Inc. and affiliates ("Roche"). The Company has also entered into non-exclusive licensing arrangements for other products recently approved for marketing. The Company is dependent upon the further development, regulatory and marketing efforts of its licensees and there can be no assurance that the development, regulatory and marketing efforts of its licensees will be successful, including, without limitation, if and when regulatory approvals in various countries may be obtained and whether or how quickly products might be adopted by the medical community. In addition, the Company recognizes royalty revenues when royalty reports are received from Roche and the Company's other licensees. This method of recognizing royalty revenues from the Company's licensees, taken together with the unpredictable timing of payments of non-recurring licensing and signing fees and milestones under new and existing collaborative research and development, humanization, patent licensing and clinical supply agreements, may result in significant fluctuations in revenues in quarterly and annual periods. Although the Company anticipates entering into new collaborations from time to time, the Company presently does not anticipate continuing to realize non-royalty revenue from its new and proposed collaborations at levels commensurate with the revenue historically recognized under its older collaborations. Moreover, the Company anticipates that it will incur significant operating expenses as the Company increases its research and development, manufacturing, preclinical, clinical, marketing and administrative and patent activities. Accordingly, in the absence of substantial revenues from new corporate collaborations or patent licensing arrangements, royalties on sales of products licensed under the Company's intellectual property rights or other sources, the Company anticipates that its operating expenses will generally continue to increase significantly as the Company expands its business activities and advances potential products in clinical development, dedicates more resources to its research and development, manufacturing, preclinical and clinical activity, and administrative and patent activities. Accordingly, in the absence of substantial revenues from new corporate collaborations, humanization and patent licensing agreements, significant royalties on sales of Zenapax and other products licensed under the Company's intellectual property rights, or other sources, the Company expects to incur substantial operating losses in the foreseeable future as certain of its earlier stage potential products move into later stage clinical development, as additional potential products are selected as clinical candidates for further development, as the Company invests in additional facilities or manufacturing capacity, as the Company defends or prosecutes its patents and patent applications and as the Company invests in research or acquires additional technologies, product candidates or businesses. Contract revenues from research and development are recorded as earned based on the performance requirements of the contracts. Revenues from achievement of milestone events are recognized when the funding party agrees that the scientific, clinical or regulatory results stipulated in the agreement have been met. Revenue recognized under certain clinical supply agreements are based on the percentage of completion method. Deferred revenue arises principally due to timing of cash payments received under research and development contracts. The Company's collaborative, humanization and patent licensing agreements with third parties provide for the payment of royalties to the Company based on net sales of the licensed product under the agreement. Royalties, as reported to the Company, may include deductions for creditable amounts related to third party royalties as well as milestone payments, certain patent expense reimbursements and maintenance fees previously received by the Company. The agreements generally provide for royalty reports to the Company following completion of each calendar quarter or semi-annual period and royalty revenue is recognized when royalty reports are received from the third party. RESULTS OF OPERATIONS Three Months Ended September 30, 1998 and 1997 The Company's total revenues for the three months ended September 30, 1998 were $11.9 million as compared to $7.0 million in 1997. Total revenues recognized under agreements with third parties were $9.6 million in the third quarter of 1998 compared to $4.6 million in the comparable period in 1997. Interest and other income amounted to $2.3 million in the third quarter of 1998 compared to $2.5 million in the comparable period in 1997. Revenues under agreements with third parties of $9.6 million for the three months ended September 30, 1998 consisted principally of a $6.0 million nonrefundable licensing and signing fee from Genentech, Inc. ("Genentech"), milestone payments earned under licensing agreements, manufacturing services revenues under clinical supply agreements, research and development reimbursement funding and royalties. In the third quarter of 1997, revenues under agreements with third parties consisted principally of $4.6 million of licensing and signing fees and milestone payments earned under licensing agreements. Total costs and expenses for the three months ended September 30, 1998 increased to $11.2 million from $7.9 million in the comparable period in 1997. The increase in costs was primarily due to the accrual of a licensing and signing fee payable to Genentech, the addition of staff in the Company's pharmaceutical research and development programs, administrative functions and associated expenses desirable to manage and support the Company's expanding operations. Research and development expenses for the three month period ended September 30, 1998 increased to $8.9 million from $6.3 million in the comparable period in 1997. The increase in costs was primarily due to the accrual of a licensing and signing fee payable to Genentech, the addition of staff, the continuation of clinical trials, costs of conducting preclinical tests and expansion of research and pharmaceutical development capabilities, including support for both clinical development and manufacturing process development. General and administrative expenses for the three months ended September 30, 1998 increased to $2.2 million from $1.6 million in the comparable period in 1997. These increases were primarily the result of increased staffing and associated expenses desirable to manage and support the Company's expanding operations. Nine Months Ended September 30, 1998 and 1997 The Company's total revenues for the nine months ended September 30, 1998 were $24.5 million as compared to $15.9 million in 1997. Total revenues recognized under agreements with third parties were $17.3 million for the nine months ended September 30, 1998 compared to $9.3 million in the comparable period in 1997. This increase in total revenues is primarily the result of increased licensing and signing fees during the period. Interest and other income for the nine months ended September 30, 1998 were $7.2 million compared to $6.6 million in the comparable period in 1997. This increase in interest and other income is primarily attributable to the increased interest earned on the Company's higher cash and cash equivalents balances as a result of the Company's follow-on public offering which was completed during the first quarter of 1997. Revenues under agreements with third parties of $17.3 million for the nine months ended September 30, 1998 consisted principally of a $6.0 million nonrefundable licensing and signing fee from Genentech, licensing and signing fees from other third parties, milestone payments earned under licensing agreements, manufacturing services revenues under clinical supply agreements, research and development reimbursement funding and royalties. In the comparable period of 1997, revenues under agreements with third parties consisted principally of $9.3 million of licensing and signing fees and milestone payments earned under licensing agreements. Total costs and expenses for the nine months ended September 30, 1998 increased to $28.7 million from $23.8 million in the comparable period in 1997. The increase in costs was primarily due to the addition of staff in the Company's pharmaceutical research and development programs, administrative functions and associated expenses desirable to manage and support the Company's expanding operations. Research and development expenses for the nine months ended September 30, 1998 increased to $22.7 million from $19.1 million in the comparable period in 1997. The increase in costs was primarily due to the addition of staff, the continuation of clinical trials and expansion of research and pharmaceutical development capabilities, including support for both clinical development and manufacturing process development. General and administrative expenses for the nine months ended September 30, 1998 increased to $6.0 million from $4.7 million in the comparable period in 1997. These increases were primarily the result of increased staffing and associated expenses desirable to manage and support the Company's expanding operations. LIQUIDITY AND CAPITAL RESOURCES To date, the Company has financed its operations primarily through public and private placements of equity securities, research and development revenues and interest income on invested capital. At September 30, 1998, the Company had cash, cash equivalents and investments in the aggregate of $145.8 million, compared to $163.7 million at December 31, 1997. This decrease was due to the year to date net loss and capital expenditures for the Company's new facility. Cash and cash equivalents and investments for the period do not include the $6.0 million licensing and signing fee received from Genentech in October 1998. In 1997, Boehringer Mannheim GmbH ("Boehringer Mannheim") invoked the dispute resolution provisions under its collaborative research agreement with the Company to address the reimbursement of up to $2.0 million for the Phase II study of OST 577 for the treatment of chronic hepatitis B ("CHB") then being conducted by Boehringer Mannheim as well as certain legal expenses related to Boehringer Mannheim's participation in the Company's public offering in the first quarter of 1997. In March 1998, Roche acquired Corange Limited, the parent company of Boehringer Mannheim. The Company is unable to predict the outcome of this proceeding but in any event has estimated and recorded a liability with respect to this matter. The collaborative research agreement with Boehringer Mannheim provides for reimbursement from PDL of costs and expenses of up to $2.0 million for a Phase II study of OST 577 in the event certain conditions were met with respect to that study. As set forth in the Statements of Cash Flows, net cash used in operating activities was $5.6 million for the nine months ended September 30, 1998 compared to $7.7 million in the same period in 1997. The decrease in 1998 was primarily due to a lower net loss for the period, an increase in accounts receivable primarily due to the Genentech licensing and signing fee, which is included in other current assets, and the Company receiving research and development reimbursement funding in advance of the related work to be performed by the Company. As set forth in the Statements of Cash Flows, net cash provided by investing activities for the nine months ended September 30, 1998 was $37.8 million, resulting primarily from maturities of short-term investments. Net cash used in investing activities for the comparable period in 1997 was $40.8 million reflecting the purchase of short- and long-term investments. The Company has a twelve year lease of approximately 90,000 square feet for its new headquarters and research and development facilities in Fremont, California. The Company has invested approximately $13 million in order to make the facilities suitable for its operations, including tenant improvements and equipment. As set forth in the Statements of Cash Flows, capital expenditures increased to $14.8 million for the nine months ended September 30, 1998 compared to $2.6 million in the comparable period in 1997, primarily from its investment in these facilities. As set forth in the Statements of Cash Flows, net cash provided by financing activities for the nine months ended September 30, 1998 was $3.3 million resulting primarily from the exercise of outstanding stock options. Net cash provided by financing activities for the comparable period in 1997 was $71.3 million. The 1997 amount resulted primarily from the completion of a public offering of 2.275 million shares of the Company's common stock in the first quarter of 1997. The Company's future capital requirements will depend on numerous factors, including, among others, royalties from sales of products of third party licensees, including Zenapax, Synagis[R] and Herceptin[R]; the ability of the Company to enter into additional collaborative, humanization and patent licensing arrangements; the progress of the Company's product candidates in clinical trials; the ability of the Company's licensees to obtain regulatory approval and successfully manufacture and market products licensed under the Company's patents; the continued or additional support by collaborative partners or other third parties of research and development efforts and clinical trials; enhancement of existing and investment in new research and development programs; the time required to gain regulatory approvals; the resources the Company devotes to self-funded products, manufacturing facilities and methods and advanced technologies; the ability of the Company to obtain and retain funding from third parties under collaborative agreements; the continued development of internal marketing and sales capabilities; the demand for the Company's potential products, if and when approved; potential acquisitions of technology, product candidates or businesses by the Company; and the costs of defending or prosecuting any patent opposition or litigation necessary to protect the Company's proprietary technology. In order to develop and commercialize its potential products the Company may need to raise substantial additional funds through equity or debt financings, collaborative arrangements, the use of sponsored research efforts or other means. No assurance can be given that such additional financing will be available on acceptable terms, if at all, and such financing may only be available on terms dilutive to existing stockholders. The Company believes that existing capital resources will be adequate to satisfy its capital needs through at least 2001. YEAR 2000 READINESS DISCLOSURE As is true for most companies, the ability of the Company's systems and equipment as well as those of its key suppliers to address the Year 2000 ("Y2K") issue presents a potential risk for the Company. If systems software and/or equipment containing embedded software or controllers do not correctly recognize date information when the year changes to 2000, there could be an adverse impact on the Company's operations. The risk for the Company exists in two areas: systems used by the Company to run its business and systems used by the Company's suppliers. The Company is currently evaluating its exposure in these two areas. The Company has also reviewed, but views as a much less significant risk, claims related to potential warranty or other claims from its collaborative research customers. Based on a preliminary assessment by an outside consultant retained by the Company in early 1998, the Company believes that its most important information systems are Y2K-compliant; however, the Company is in the process of conducting a comprehensive inventory and evaluation of its systems, equipment and facilities. In connection with its recent move to a new headquarters facility in Fremont, California, the Company has replaced or upgraded many of its systems and equipment that were known or believed to present potential Y2K problems. In addition, the Company specifically identified and contacted certain key vendors regarding Y2K compliance of its key information systems and has either received software upgrades or assurances that Y2K-compliant software will be made available in a manner designed for the Company to timely address the Y2K issue with respect to these systems. As part of its comprehensive review of potentially affected systems, equipment and facilities, the Company is also reviewing controllers used to perform key functions in its manufacturing facility in Plymouth, Minnesota. At this time, the Company has not reviewed all systems and processes for potential Y2K problems nor has the Company identified alternative remediation plans if upgrade or replacement is not feasible. The Company will consider the need for such remediation or replacement plans as it continues to assess the Y2K risk. For Y2K non-compliance issues identified to date, the cost of upgrade or remediation has not been and is not expected to be material to the Company's operating results. The Company expects to conclude its initial estimates of total anticipated costs to become Y2K-compliant by the end of the calendar year. If implementation of replacement systems is delayed, or if significant new non-compliance issues are identified, the Company's results of operations or financial condition could be materially adversely affected. The Company has identified critical suppliers and has plans to initiate inquiries in order to determine whether the operations and the products or services provided by these identified vendors are Y2K- compliant. Where practicable, the Company will attempt to mitigate its risks with respect to the failure of vendors to be Y2K-compliant. In the event that vendors are not compliant, the Company will seek alternative sources of supplies or services. However, many of the Company's vendors have been qualified for regulatory purposes and qualifying new vendors could involve significant time and resource commitments by the Company. Failure of vendors to be Y2K-compliant remains a possibility and could limit the ability of the Company to manufacture material for clinical studies or timely conduct regulatory compliance programs that would result in a delay in the initiation or continuation of certain planned clinical studies. Significant delays or expenditures due to vendors' failures to become Y2K-compliant could have an adverse impact on the Company's results of operations or financial condition. With respect to research conducted by the Company in support of its collaborative research customers, many of the systems used to support such efforts are new. Where appropriate, the Company has, as a condition to accepting such systems, required that the systems be Y2K- compliant. PART II. OTHER INFORMATION ITEM 5. OTHER INFORMATION - RISK FACTORS This Quarterly Report contains, in addition to historical information, forward-looking statements which involve risks and uncertainties. The Company's actual results may differ significantly from the results discussed in forward-looking statements. Factors that may cause such a difference include those discussed in the material set forth under "Risk Factors" and elsewhere in this document and in the Company's Annual Report on Form 10-K for the year ending December 31, 1997. History Of Losses; Future Profitability Uncertain. The Company has a history of operating losses and expects to incur substantial additional expenses with resulting quarterly losses over at least the next several years as it continues to develop its potential products, to invest in new research areas and to devote significant resources to preclinical studies, clinical trials and manufacturing. As of September 30, 1998, the Company had an accumulated deficit of approximately $63.6 million. The time and resource commitment required to achieve market success for any individual product is extensive and uncertain. No assurance can be given that the Company, its collaborative partners or licensees will successfully develop products, obtain required regulatory approvals, manufacture products at an acceptable cost and with appropriate quality, or successfully market such products. The Company's revenues to date have consisted principally of research and development funding, licensing and signing fees and milestone payments from pharmaceutical and biotechnology companies under collaborative research and development, humanization, patent licensing and clinical supply agreements. These revenues may vary considerably from quarter to quarter and from year to year, and revenues in any period may not be predictive of revenues in any subsequent period, and variations may be significant depending on the terms of the particular agreements. Although the Company anticipates entering into new collaborations from time to time, the Company presently does not anticipate continuing to realize non-royalty revenue from its new and proposed collaborations at levels commensurate with the revenue historically recognized under its older collaborations. Moreover, the Company anticipates that it will incur significant operating expenses as the Company increases its research and development, manufacturing, preclinical, clinical, marketing and administrative and patent activities. Accordingly, in the absence of substantial revenues from new corporate collaborations or patent licensing arrangements, royalties on sales of products licensed under the Company's intellectual property rights or other sources, the Company anticipates that its operating expenses will continue to increase significantly as the Company increases its research and development, manufacturing, preclinical and clinical activity, and administrative and patent activities. Accordingly, in the absence of substantial revenues from new corporate collaborations or patent licensing agreements, significant royalties on sales of Zenapax[R] and other products licensed under the Company's intellectual property rights, or other sources, the Company expects to incur substantial operating losses in the foreseeable future as certain of its earlier stage potential products move into later stage clinical development, as additional potential products are selected as clinical candidates for further development, as the Company invests in additional facilities or manufacturing capacity, as the Company defends or prosecutes its patents and patent applications and as the Company invests in research or acquires additional technologies, product candidates or businesses. For example, revenues in the third quarter of 1998 included a $6.0 million non-refundable licensing and signing fee from Genentech, Inc. ("Genentech") that resulted in a profit in that quarter. In the absence of similar substantial non-recurring revenues or significant royalty revenues in any future period, there can be no assurance that the Company will be profitable in any future quarters. Hoffmann-La Roche Inc. and its affiliates ("Roche") have received regulatory approval to distribute Zenapax in the U.S. and certain other countries. Zenapax, a product created by the Company, is licensed exclusively to Roche. The Company has also entered into nonexclusive patent license agreements covering Synagis[R], a product developed by MedImmune, Inc., and Herceptin[R], a product developed by Genentech. The Company recognizes royalty revenues when royalty reports are received from its collaborative partners, including Roche. With respect to royalties based on revenue from sales of Zenapax by Roche, royalties based on U.S. sales are reported to the Company on a quarterly basis and royalties based on sales outside of the U.S. are reported on a semi- annual basis. With respect to royalties on sales of Synagis and Herceptin, royalty reports are due in the quarter following the quarter in which sales occur or are reported by sublicensees, as the case may be. Each of these licensees has certain rights to partially offset certain payments previously made to the Company or paid to third parties. For example, Roche has a right to offset certain third party royalties, patent reimbursement expenses and previously paid milestones against royalties payable to the Company with respect to Zenapax. The Company records revenue when reports are received from its licensees. This method of accounting for royalty revenues from the Company's licensees, taken together with the unpredictable timing of payments of non-recurring licensing and signing fees, payments for manufacturing services and milestones under new and existing collaborative, humanization, patent licensing and clinical supply agreements, is likely to result in significant quarterly fluctuations in revenues in quarterly and annual periods. Thus, revenues in any period may not be predictive of revenues in any subsequent period, and variations may be significant depending on the terms of the particular agreements. The Company anticipates that it will incur significant operating expenses as the Company increases its research and development, manufacturing, preclinical, clinical, marketing and administrative and patent activities. Accordingly, in the absence of substantial revenues from new corporate collaborations or patent licensing arrangements, royalties on sales of Zenapax or other products licensed under the Company's intellectual property rights or other sources, the Company expects to incur substantial operating losses in the foreseeable future as certain of its earlier stage potential products move into later stage clinical development, as additional potential products are selected as clinical candidates for further development, as the Company invests in new headquarters and additional laboratory and manufacturing facilities or capacity, as the Company defends or prosecutes its patents and patent applications, and as the Company invests in continuing and new research programs or acquires additional technologies, product candidates or businesses. For example, the Company has invested approximately $13 million in order to make its new headquarters facilities located in Fremont, California suitable for its operations, including investment in tenant improvements and capital equipment. The amount of net losses and the time required to reach sustained profitability are highly uncertain. To achieve sustained profitable operations, the Company, alone or with its collaborative partners, must successfully discover, develop, manufacture, obtain regulatory approvals for and market potential products. No assurances can be given that the Company will be able to achieve or sustain profitability, and results are expected to fluctuate from quarter to quarter and year to year. Dependence On Licensees With Respect to Marketed Products. The Company is dependent upon the development and marketing efforts of its licensees with respect to products for which the Company may receive royalties. For example, in 1998, the Company began receiving royalties from sales of Zenapax, a product exclusively licensed to Roche. The Company's royalties on Zenapax depend upon the development efforts of Roche and there can be no assurance that Roche's development, regulatory and marketing efforts will be successful, including without limitation, whether or how quickly Zenapax might receive regulatory approvals in various countries throughout the world and how rapidly it might be adopted by the medical community. Moreover, Simulect[R], a product competitive with Zenapax, has been approved for marketing in the U.S. and other countries and there can be no assurance that Roche will successfully market and sell Zenapax against this and other available competitive products. In addition, there can be no assurance that other independently developed products of Roche, including CellCept[R], or others will not compete with or prevent Zenapax from achieving meaningful sales. Roche's development and marketing efforts for CellCept may result in delays or a relatively smaller resource commitment to product launch and support efforts than might otherwise be obtained for Zenapax if this potentially competitive product were not under development or being marketed. In addition, Zenapax is being tested in certain early stage clinical trials in autoimmune indications. There can be no assurance that Roche will continue or pursue additional clinical trials in these indications or that, even if the additional clinical trials are completed, Zenapax will be shown to be safe and efficacious, or that the clinical trials will result in approval to market Zenapax in these indications. Any adverse event or announcement related to Zenapax would have a material adverse effect on the business and financial condition of the Company. The Company has also entered into non-exclusive patent licensing arrangements for certain products recently approved for marketing, specifically Synagis[R] and Herceptin[R]. The Company is dependent upon the further development, regulatory and marketing efforts of its licensees with respect to these products and there can be no assurance that the development, regulatory and marketing efforts of these licensees will be successful, including, without limitation, if and when regulatory approvals in various countries may be obtained and whether or how quickly products might be adopted by the medical community. Uncertainty Of Clinical Trial Results. Before obtaining regulatory approval for the commercial sale of any of its potential products, the Company must demonstrate through preclinical studies and clinical trials that the product is safe and efficacious for use in the clinical indication for which approval is sought. There can be no assurance that the Company will be permitted to undertake or continue clinical trials for any of its potential products or, if permitted, that such products will be demonstrated to be safe and efficacious. Moreover, the results from preclinical studies and early-stage clinical trials may not be predictive of results that will be obtained in late-stage clinical trials. Thus, there can be no assurance that the Company's present or future clinical trials will demonstrate the safety and efficacy of any potential products or will result in approval to market products. In advanced clinical development, numerous factors may be involved that may lead to different results in larger, late-stage clinical trials from those obtained in early-stage trials. For example, early-stage clinical trials usually involve a small number of patients, often at a single center, and thus may not accurately predict the actual results regarding safety and efficacy that may be demonstrated with a large number of patients in a late-stage multi-center clinical trial. Also, differences in the clinical trial design between early-stage and late- stage clinical trials may cause different results regarding the safety and efficacy of a product to be obtained. In addition, many early-stage trials are unblinded and based on qualitative evaluations by clinicians involved in the performance of the trial, whereas late-stage trials are generally required to be blinded in order to provide more objective data for assessing the safety and efficacy of the product. Moreover, preliminary results from clinical trials may not be representative of results that may be obtained as the trial proceeds to completion. The Company may at times elect to aggressively enter potential products into Phase I/II trials to determine preliminary efficacy in specific indications. In addition, in certain cases the Company has commenced clinical trials without conducting preclinical animal testing where an appropriate animal model does not exist. Similarly, the Company or its partners at times will conduct potentially pivotal Phase II/III or Phase III trials based on limited Phase I or Phase I/II data. As a result of these and other factors, the Company anticipates that only some of its potential products will show safety and efficacy in clinical trials and that the number of products that fail to show safety and efficacy may be significant. Limited Experience With Clinical Trials; Risk Of Delay. The Company has conducted only a limited number of clinical trials to date. There can be no assurance that the Company will be able to successfully commence and complete all of its planned clinical trials without significant additional resources and expertise. In addition, there can be no assurance that the Company will meet its contemplated development schedule for any of its potential products. The inability of the Company or its collaborative partners to commence or continue clinical trials as currently planned, to complete the clinical trials on a timely basis or to demonstrate the safety and efficacy of its potential products, would have a material adverse effect on the business and financial condition of the Company. The rate of completion of the Company's or its collaborators' clinical trials is significantly dependent upon, among other factors, the rate of patient enrollment. Patient enrollment is a function of many factors, including, among others, the size of the patient population, perceived risks and benefits of the drug under study, availability of competing therapies, access to reimbursement from insurance companies or government sources, design of the protocol, proximity of and access by patients to clinical sites, patient referral practices, eligibility criteria for the study in question and efforts of the sponsor of and clinical sites involved in the trial to facilitate timely enrollment in the trial. Delays in the planned rate of patient enrollment may result in increased costs and expenses in completion of the trial or may require the Company to undertake additional studies in order to obtain regulatory approval if the applicable standard of care changes in the therapeutic indication under study. These considerations may lead the Company to consider the termination of ongoing clinical trials or halting further development of a product for a particular indication. Uncertainty Of Patents And Proprietary Technology; Opposition Proceedings. The Company's success is significantly dependent on its ability to obtain patent protection for its products and technologies and to preserve its trade secrets and operate without infringing on the proprietary rights of third parties. The Company files and prosecutes patent applications to protect its inventions. No assurance can be given that the Company's pending patent applications will result in the issuance of patents or that any patents will provide competitive advantages or will not be invalidated or circumvented by its competitors. Moreover, no assurance can be given that patents are not issued to, or patent applications have not been filed by, other companies which would have an adverse effect on the Company's ability to use, manufacture or market its products or maintain its competitive position with respect to its products. Other companies obtaining patents claiming products or processes useful to the Company may bring infringement actions against the Company. As a result, the Company may be required to obtain licenses from others or not be able to use, manufacture or market its products. Such licenses may not be available on commercially reasonable terms, if at all. Patents in the U.S. are issued to the party that is first to invent the claimed invention. Since patent applications in the U.S. are maintained in secrecy until patents issue, the Company cannot be certain that it was the first inventor of the inventions covered by its pending patent applications or that it was the first to file patent applications for such inventions. The patent positions of biotechnology firms generally are highly uncertain and involve complex legal and factual questions. No consistent policy has emerged regarding the breadth of claims in biotechnology patents, and patents of biotechnology products are uncertain so that even issued patents may later be modified or revoked by the U.S. Patent and Trademark Office ("PTO") or the courts in proceedings instituted by third parties. Moreover, the issuance of a patent in one country does not assure the issuance of a patent with similar claims in another country and claim interpretation and infringement laws vary among countries, so the extent of any patent protection may vary in different territories. The Company has several patents and exclusive licenses covering its humanized and human antibody technology, respectively. With respect to its human antibody technology and antibodies, the Company has exclusively licensed certain patents from Novartis Pharmaceuticals Corporation ("Novartis") (formerly known as Sandoz Pharmaceuticals Corporation). With respect to its SMART[TM] antibody technology and antibodies, the Company has been issued fundamental patents by the European Patent Office ("EPO") and PTO. In addition, in June 1996 the Company was issued a U.S. patent covering Zenapax and certain related antibodies against the IL-2 receptor. The Company is also currently prosecuting other patent applications with the PTO and in other countries, including members of the European Patent Convention, Canada, Japan and Australia. The patent applications are directed to various aspects of the Company's SMART and human antibodies, antibody technology and other programs, and include claims relating to compositions of matter, methods of preparation and use of a number of the Company's compounds. However, the Company does not know whether any of these pending applications will result in the issuance of patents or whether such patents will provide protection of commercial significance. Further, there can be no assurance that the Company's patents will prevent others from developing competitive products using related or other technology. With respect to its issued antibody humanization patents, the Company believes the patent claims cover Zenapax, Herceptin and Synagis and, based on its review of the scientific literature, most humanized antibodies. The EPO (but not PTO) procedures provide that other parties may submit arguments as to why the patent was incorrectly granted and should be withdrawn or limited. Eighteen notices of opposition and opposition briefs to the Company's European patent were filed, including filings by major pharmaceutical and biotechnology companies, which cited references and made arguments not considered by the EPO and PTO before grant of the respective patents. The entire opposition process, including appeals, may take several years to complete, and during this lengthy process, the validity of the EPO patent will be at issue, which may limit the Company's ability to negotiate or collect royalties or to negotiate future collaborative research and development agreements based on this patent. The Company intends to vigorously defend the European patent and, if necessary, the U.S. patent; however, there can be no assurance that the Company will prevail in the opposition proceedings or any litigation contesting the validity or scope of these patents. If the outcome of the European opposition proceeding or any litigation involving the Company's antibody humanization patents were to be unfavorable, the Company's ability to collect royalties on licensed products and to license its patents relating to humanized antibodies may be materially adversely affected, which could have a material adverse affect on the business and financial conditions of the Company. In addition, such proceedings or litigation, or any other proceedings or litigation to protect the Company's intellectual property rights or defend against infringement claims by others, could result in substantial costs and a diversion of management's time and attention, which could have a material adverse effect on the business and financial condition of the Company. A number of companies, universities and research institutions have filed patent applications or received patents in the areas of antibodies and other fields relating to the Company's programs. Some of these applications or patents may be competitive with the Company's applications or contain claims that conflict with those made under the Company's patent applications or patents. Such conflict could prevent issuance of patents to the Company, provoke an interference with the Company's patents or result in a significant reduction in the scope or invalidation of the Company's patents, if issued. An interference is an administrative proceeding conducted by the PTO to determine the priority of invention and other matters relating to the decision to grant patents. Moreover, if patents are held by or issued to other parties that contain claims relating to the Company's products or processes, and such claims are ultimately determined to be valid, no assurance can be given that the Company would be able to obtain licenses to these patents at a reasonable cost, if at all, or to develop or obtain alternative technology. The Company is aware that Celltech Limited ("Celltech") has been granted a patent by the EPO covering certain humanized antibodies, which PDL has opposed, and that Celltech has a pending application for a corresponding U.S. patent (the "U.S. Adair Patent Application"). Because U.S. patent applications are maintained in secrecy, the U.S. Adair Patent Application remains confidential. Accordingly, there can be no assurance that claims in such a patent or application would not cover any of the Company's SMART antibodies or be competitive with or conflict with claims in the Company's patents or patent applications. If the U.S. Adair Patent Application issues and if it is determined to be valid and to cover any of the Company's SMART antibodies, there can be no assurance that PDL would be able to obtain a license on commercially reasonable terms, if at all. If the claims of the U.S. Adair Patent Application conflict with claims in the Company's patents or patent applications, there can be no assurance that an interference would not be declared by the PTO, which could take several years to resolve and could involve significant expense to the Company. Also, such conflict could prevent issuance of additional patents to PDL relating to humanization of antibodies or result in a significant reduction in the scope or invalidation of the Company's patents, if issued. Moreover, uncertainty as to the validity or scope of patents issued to the Company relating generally to humanization of antibodies may limit the Company's ability to negotiate or collect royalties or to negotiate future collaborative research and development agreements based on these patents. The Company is aware that Lonza Biologics, Inc. has a patent issued in Europe to which the Company does not have a license (although Roche has advised the Company that it has a license covering Zenapax), which may cover the process the Company uses to produce its potential products. If it were determined that the Company's processes were covered by such patent, the Company might be required to obtain a license under such patent or to significantly alter its processes or products, if necessary to manufacture or import its products in Europe. There can be no assurance that the Company would be able to successfully alter its processes or products to avoid infringing such patent or to obtain such a license on commercially reasonable terms, if at all, and the failure to do so could have a material adverse effect on the business and financial condition of the Company. Moreover, any alteration of processes or products to avoid infringing the patent could result in a significant delay in achieving regulatory approval with respect to the products affected by such alterations. The Company is also aware that Stanford University has a patent issued in the U.S. to which the Company does not have a license, which may cover the process the Company uses to produce its potential products. The Company has been advised that an exclusive license has been previously granted to a third party under this patent. If it were determined that the Company's processes were covered by such patent, the Company might be required to obtain a license under such patent or to significantly alter its processes or products, if necessary to manufacture or import its products in the U.S. There can be no assurance that the Company would be able to successfully alter its processes or products to avoid infringing such patent or to obtain such a license on commercially reasonable terms, if at all, and the failure to do so could have a material adverse effect on the business and financial condition of the Company. Moreover, any alteration of processes or products to avoid infringing the patent could result in a significant delay in achieving regulatory approval with respect to the products affected by such alterations. In addition to seeking the protection of patents and licenses, the Company also relies upon trade secrets, know-how and continuing technological innovation which it seeks to protect, in part, by confidentiality agreements with employees, consultants, suppliers and licensees. There can be no assurance that these agreements will not be breached, that the Company would have adequate remedies for any breach or that the Company's trade secrets will not otherwise become known, independently developed or patented by competitors. Dependence On Collaborative Partners. The Company has collaborative agreements with several pharmaceutical or other companies to develop, manufacture and market certain potential products, which include Zenapax, the most advanced product of the Company. The Company granted its collaborative partners certain exclusive rights to commercialize the products covered by these collaborative agreements. In some cases, the Company is relying on its collaborative partners to conduct clinical trials, to compile and analyze the data received from such trials, to obtain regulatory approvals and, if approved, to manufacture and market these licensed products. As a result, the Company often has little or no control over the development and marketing of these potential products and little or no opportunity to review clinical data prior to or following public announcement. The Company's collaborative research agreements are generally terminable by its partners on short notice. Suspension or termination of certain of the Company's current collaborative research agreements could have a material adverse effect on the Company's operations and could significantly delay the development of the affected products. For example, Boehringer Mannheim GmbH ("Boehringer Mannheim") and the Company from time to time had differences with respect to the clinical development of certain products licensed by the Company to Boehringer Mannheim under a collaborative agreement. In December 1997, as a result of Boehringer Mannheim's internal review of products licensed from the Company, product rights to OST 577 were returned to the Company. In March 1998, Roche acquired Corange Limited ("Corange"), the parent company of Boehringer Mannheim. Roche's review of the products acquired from Boehringer Mannheim resulted in a decision to return the SMART Anti-L-Selectin Antibody and an antibody directed against an undisclosed cardiovascular target to the Company effective as of December 31, 1998. Although the Company is assessing its development alternatives with respect to these antibodies, the development of these compounds has been delayed significantly and there can be no assurance that the Company will continue or initiate further development efforts with any of these compounds. In addition, Roche acquired 1,682,877 shares of the Company's common stock held by Corange which are no longer subject to contractual limitations on disposition other than certain restrictions on transfers of significant blocks of stock. Further, Boehringer Mannheim has invoked the dispute resolution provisions under its collaborative research agreement to address the reimbursement of up to $2.0 million for the Phase II study of OST 577 for the treatment of chronic hepatitis B ("CHB") conducted by Boehringer Mannheim. The Company is unable to predict the outcome of this proceeding but in any event has estimated and recorded a liability with respect to this matter. Continued funding and participation by collaborative partners will depend on the timely achievement of research and development objectives by the Company, the retention of key personnel performing work under those agreements and the successful achievement of research or clinical trial goals, none of which can be assured, as well as on each collaborative partner's own financial, competitive, marketing and strategic considerations. Such considerations include, among other things, the commitment of management of the collaborative partners to the continued development of the licensed products, the relationships among the individuals responsible for the implementation and maintenance of the collaborative efforts, the relative advantages of alternative products being marketed or developed by the collaborators or by others, including their relative patent and proprietary technology positions, and their ability to manufacture potential products successfully. The Company's ability to enter into new collaborations and the willingness of the Company's existing collaborators to continue development of the Company's potential products depends upon, among other things, the Company's patent position with respect to such products. In this regard, the Company has been issued patents by PTO and EPO with claims that the Company believes, based on its survey of the scientific literature, cover most humanized antibodies. Eighteen notices of opposition and opposition briefs to the European patent have been filed with the EPO, and either or both patents may be further challenged through administrative or judicial proceedings. The Company has also been allowed patents with similar claims in other countries and has applied for similar patents in certain other countries. The Company has entered into several collaborations related to both the humanization and patent licensing of certain antibodies whereby it granted licenses to its patent rights relating to such antibodies, and the Company anticipates entering into additional collaborations and patent licensing agreements partially as a result of the Company's patent and patent applications with respect to humanized antibodies. As a result, the inability of the Company to successfully defend the opposition proceeding before the EPO or, if necessary, to defend patents granted by the PTO or EPO, or to successfully prosecute the corresponding patent applications in other countries could adversely affect the ability of the Company to collect royalties on existing licensed products, and enter into additional collaborations, humanization or patent licensing agreements and could therefore have a material adverse effect on the Company's business or financial condition. Absence Of Manufacturing Experience. Of the products developed by the Company which are currently in clinical development, Roche is responsible for manufacturing Zenapax and the Company is responsible for manufacturing OST 577 and the SMART M195 and SMART Anti-CD3 Antibodies as well as its other products in preclinical development. The Company currently leases approximately 47,000 square feet housing its manufacturing facilities in Plymouth, Minnesota. The Company intends to continue to manufacture potential products for use in preclinical and clinical trials using this manufacturing facility in accordance with standard procedures that comply with current Good Manufacturing Practices ("cGMP") and appropriate regulatory standards. The manufacture of sufficient quantities of antibody products in accordance with such standards is an expensive, time-consuming and complex process and is subject to a number of risks that could result in delays. For example, the Company has experienced some difficulties in the past in manufacturing certain potential products on a consistent basis. Production interruptions, if they occur, could significantly delay clinical development of potential products, reduce third party or clinical researcher interest and support of proposed clinical trials, and possibly delay commercialization of such products and impair their competitive position, which would have a material adverse effect on the business and financial condition of the Company. The Company has no experience in manufacturing commercial quantities of its potential products and currently does not have sufficient capacity to manufacture all of its potential products on a commercial scale. In order to obtain regulatory approvals and to create capacity to produce its products for commercial sale at an acceptable cost, the Company will need to improve and expand its existing manufacturing capabilities, including demonstration to the FDA and corresponding foreign authorities of its ability to manufacture its products using controlled, reproducible processes. Accordingly, the Company is evaluating plans to improve and expand the capacity of its current manufacturing facility. Such plans, if fully implemented, would result in substantial costs to the Company and may require a suspension of manufacturing operations during construction. There can be no assurance that construction delays would not occur, and any such delays could impair the Company's ability to produce adequate supplies of its potential products for clinical use or commercial sale on a timely basis. Further, there can be no assurance that the Company will successfully improve and expand its manufacturing capability sufficiently to obtain necessary regulatory approvals and to produce adequate commercial supplies of its potential products on a timely basis. Failure to do so could delay commercialization of such products and impair their competitive position, which could have a material adverse effect on the business or financial condition of the Company. Uncertainties Resulting From Manufacturing Changes. Manufacturing of antibodies for use as therapeutics in compliance with regulatory requirements is complex, time-consuming and expensive. When certain changes are made in the manufacturing process, it is necessary to demonstrate to the FDA and corresponding foreign authorities that the changes have not caused the resulting drug material to differ significantly from the drug material previously produced, if results of prior preclinical studies and clinical trials performed using the previously produced drug material are to be relied upon in regulatory filings. Such changes could include, for example, changing the cell line used to produce the antibody, changing the fermentation or purification process or moving the production process to a new manufacturing plant. Depending upon the type and degree of differences between the newer and older drug material, various studies could be required to demonstrate that the newly produced drug material is sufficiently similar to the previously produced drug material, possibly requiring additional animal studies or human clinical trials. Manufacturing changes have been made or are likely to be made for the production of the Company's products currently in clinical development, in particular OST 577, and the SMART M195 and SMART Anti-CD3 antibodies. There can be no assurance that such changes will not result in delays in development or regulatory approvals or, if occurring after regulatory approval, in reduction or interruption of commercial sales. In addition, manufacturing changes to its manufacturing facility may require the Company to shut down production for a period of time. There can be no assurance that the Company will be able to reinitiate production in a timely manner, if at all, following such shutdown. Delays as a result of manufacturing changes or shutdown of the manufacturing facility could have an adverse effect on the competitive position of those products and could have a material adverse effect on the business and financial condition of the Company. Dependence On Suppliers. The Company is dependent on outside vendors for the supply of raw materials used to produce its product candidates. The Company currently qualifies only one or a few vendors for its source of certain raw materials. Therefore, once a supplier's materials have been selected for use in the Company's manufacturing process, the supplier in effect becomes a sole or limited source of such raw materials to the Company due to the extensive regulatory compliance procedures governing changes in manufacturing processes. Although the Company believes it could qualify alternative suppliers, there can be no assurance that the Company would not experience a disruption in manufacturing if it experienced a disruption in supply from any of these sources. Any significant interruption in the supply of any of the raw materials currently obtained from such sources, or the time and expense necessary to transition a replacement supplier's product into the Company's manufacturing process, could disrupt the Company's operations and have a material adverse effect on the business and financial condition of the Company. A problem or suspected problem with the quality of raw materials supplied could result in a suspension of clinical trials, notification of patients treated with products or product candidates produced using such materials, potential product liability claims, a recall of products or product candidates produced using such materials, and an interruption of supplies, any of which could have a material adverse effect on the business or financial condition of the Company. Competition; Rapid Technological Change. The Company's potential products are intended to address a wide variety of disease conditions, including autoimmune diseases, inflammatory conditions, cancers and viral infections. Competition with respect to these disease conditions is intense and is expected to increase. This competition involves, among other things, successful research and development efforts, obtaining appropriate regulatory approvals, establishing and defending intellectual property rights, successful product manufacturing, marketing, distribution, market and physician acceptance, patient compliance, price and potentially securing eligibility for reimbursement or payment for the use of the Company's product. The Company believes its most significant competitors may be fully integrated pharmaceutical companies with substantial expertise in research and development, manufacturing, testing, obtaining regulatory approvals, marketing and securing eligibility for reimbursement or payment, and substantially greater financial and other resources than the Company. Smaller companies also may prove to be significant competitors, particularly through collaborative arrangements with large pharmaceutical companies. Furthermore, academic institutions, governmental agencies and other public and private research organizations conduct research, seek patent protection, and establish collaborative arrangements for product development, clinical development and marketing. These companies and institutions also compete with the Company in recruiting and retaining highly qualified personnel. The biotechnology and pharmaceutical industries are subject to rapid and substantial technological change. The Company's competitors may develop and introduce other technologies or approaches to accomplishing the intended purposes of the Company's products which may render the Company's technologies and products noncompetitive and obsolete. In addition to currently marketed competitive drugs, the Company is aware of potential products in research or development by its competitors that address all of the diseases being targeted by the Company. These and other products may compete directly with the potential products being developed by the Company. In this regard, the Company is aware that potential competitors are developing antibodies or other compounds for treating autoimmune diseases, inflammatory conditions, cancers and viral infections. In particular, a number of other companies have developed and will continue to develop human and humanized antibodies. In addition, protein design is being actively pursued at a number of academic and commercial organizations, and several companies have developed or may develop technologies that can compete with the Company's SMART and human antibody technologies. There can be no assurance that competitors will not succeed in more rapidly developing and marketing technologies and products that are more effective than the products being developed by the Company or that would render the Company's products or technology obsolete or noncompetitive. Further, there can be no assurance that the Company's collaborative partners will not independently develop products competitive with those licensed to such partners by the Company, thereby reducing the likelihood that the Company will receive revenues under its agreements with such partners. Any potential product that the Company or its collaborative partners succeed in developing and obtaining regulatory approval for must then compete for market acceptance and market share. For certain of the Company's potential products, an important factor will be the timing of market introduction of competitive products. Accordingly, the relative speed with which the Company and its collaborative partners can develop products, complete the clinical testing and approval processes, and supply commercial quantities of the products to the market compared to competitive companies is expected to be an important determinant of market success. For example, Novartis has received approval to market Simulect[R], a product competitive with Zenapax, in the U.S. and Switzerland. Novartis has a significant marketing and sales force directed to the transplantation market and there can be no assurance that Roche will successfully market and sell Zenapax against this and other available products. With respect to the speed of development of OST 577, the Company is aware that other drugs such as lamivudine from Glaxo Wellcome plc have received or been submitted for approval in certain jurisdictions for the treatment of CHB. These competitive products are being developed by companies that have significantly greater experience and resources in developing antiviral products than the Company. The Company's current clinical plans for OST 577 involve a study of the combination of OST 577 and nucleoside analogs such as lamivudine. The success of lamivudine or other drugs for the treatment of CHB could have a material adverse impact on the clinical development and commercial potential of OST 577. Other competitive factors include the capabilities of the Company's collaborative partners, product efficacy and safety, timing and scope of regulatory approval, product availability, marketing and sales capabilities, reimbursement coverage, the amount of clinical benefit of the Company's products relative to their cost, method of administration, price and patent protection. There can be no assurance that the Company's competitors will not develop more efficacious or more affordable products, or achieve earlier product development completion, patent protection, regulatory approval or product commercialization than the Company. The occurrence of any of these events by the Company's competitors could have a material adverse effect on the business and financial condition of the Company. Dependence on Key Personnel. The Company's success is dependent to a significant degree on its key management personnel. To be successful, the Company will have to retain its qualified clinical, manufacturing, scientific and management personnel. The Company faces competition for personnel from other companies, academic institutions, government entities and other organizations. There can be no assurance that the Company will be successful in hiring or retaining qualified personnel, and its failure to do so could have a material adverse effect on the business and financial condition of the Company. Potential Volatility Of Stock Price. The market for the Company's securities is volatile and investment in these securities involves substantial risk. The market prices for securities of biotechnology companies (including the Company) have been highly volatile, and the stock market from time to time has experienced significant price and volume fluctuations that may be unrelated to the operating performance of particular companies. Factors such as disappointing sales of approved products, approval or introduction of competing products, results of clinical trials, delays in manufacturing or clinical trial plans, fluctuations in the Company's operating results, disputes or disagreements with collaborative partners, market reaction to announcements by other biotechnology or pharmaceutical companies, announcements of technological innovations or new commercial therapeutic products by the Company or its competitors, initiation, termination or modification of agreements with collaborative partners, failures or unexpected delays in manufacturing or in obtaining regulatory approvals or FDA advisory panel recommendations, developments or disputes as to patent or other proprietary rights, loss of key personnel, litigation, public concern as to the safety of drugs developed by the Company, regulatory developments in either the U.S. or foreign countries (such as opinions, recommendations or statements by the FDA or FDA advisory panels, health care reform measures or proposals), market acceptance of products developed and marketed by the Company's collaborators, sales of the Company's common stock held by collaborative partners or insiders and general market conditions could result in the Company's failure to meet the expectations of securities analysts or investors. In such event, or in the event that adverse conditions prevail or are perceived to prevail with respect to the Company's business, the price of the Company's common stock would likely drop significantly. In the past, following significant drops in the price of a company's common stock, securities class action litigation has often been instituted against such a company. Such litigation against the Company could result in substantial costs and a diversion of management's attention and resources, which would have a material adverse effect on the Company's business and financial condition. ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K (a) Exhibits - None 10.10 Patent Licensing Master Agreement between the Company and Genentech, Inc., dated as of September 25, 1998 (with certain confidential information deleted and marked by brackets surrounding the deleted portions). (b) No Reports on Form 8-K were filed during the quarter ended September 30, 1998. SIGNATURE Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its be half by the undersigned thereunto duly authorized. Dated: November 13, 1998 PROTEIN DESIGN LABS, INC. (Registrant) /s/ Laurence Jay Korn Laurence Jay Korn Chief Executive Officer, Chairperson of the Board of Directors (Principal Executive Officer) /s/ Jon Saxe Jon Saxe President (Chief Accounting Officer)
Confidential Treatment Requested

PATENT LICENSING MASTER AGREEMENT

This PATENT LICENSING MASTER AGREEMENT (the "Agreement") is entered into as 
of September 25, 1998 (the "Effective Date") by and between Protein Design 
Labs, Inc., a corporation organized and existing under the laws of the State 
of Delaware and having its principal office at 34801 Campus Drive, Fremont, 
California 94555 (hereinafter referred to as "PDL"), and Genentech, Inc., a 
corporation organized and existing under the laws of the State of Delaware and 
having its principal office at 1 DNA Way, South San Francisco, California  
94080 (hereinafter referred to as "GNE").

RECITALS

       WHEREAS, PDL has exclusive rights to certain patents designated as the 
Queen patents;

       WHEREAS, GNE has exclusive rights to certain patents designated as the 
Cabilly patents;

       WHEREAS, GNE desires to obtain certain nonexclusive license rights under
the Queen patents for the development, manufacture and commercialization of 
antibody products directed against up to six [     ] antigens under the terms 
and conditions set forth below;

       WHEREAS, PDL desires to obtain certain nonexclusive license rights under
the Cabilly patents for the development, manufacture and commercialization of 
antibody products directed against up to six [     ] antigens under the terms 
and conditions set forth below.

AGREEMENT 

        NOW, THEREFORE, the parties agree as follows:

1.  DEFINITIONS

All references to particular Exhibits, Articles and Sections shall mean the 
Exhibits to, and Articles and Sections of, this Agreement, unless otherwise 
specified.  References to this "Agreement" include the Exhibits.  For the 
purposes of this Agreement the following words and phrases shall have the 
following meanings:

1.1  "Affiliate" means any corporation or other business entity controlled 
by, controlling, or under common control with another entity, with "control" 
meaning direct or indirect beneficial ownership of more than fifty percent 
(50%) of the voting stock of such corporation, or more than a fifty percent 
(50%) interest in the decision-making authority of such other unincorporated 
business entity; and a corporation in which the maximum amount of stock 
permitted by law to be held by another entity is beneficially owned by such 
other entity.  Notwithstanding the foregoing, the term "Affiliate" under this 
Agreement with respect to GNE shall not include Roche Holdings, Inc., 
including its affiliated companies ("Roche"), until assignment of this 
Agreement to a member of such enterprise in accordance with Section 11.1.

1.2  "Antibody" means any antibody directed against an Antigen and shall 
include, without limitation, monospecific and bispecific antibodies (but a 
separate license shall be required for the antigen involved for each arm of  a 
bispecific antibody); less than full-length antibody forms such as Fv, Fab, 
and F(ab')2; single-chain antibodies; and antibody conjugates bound to a 
toxin, label or other moiety.  The term "Antibody" shall include any and all 
such constructs directed against any particular Antigen.

1.3  "Antigen" means a target molecule, usually a protein, to which an 
Antibody specifically binds and includes all epitopes on that target molecule.

1.4  "Europe" means the European Patent Convention Member Countries, 
including any successor organization and any additional countries that may 
join such organization from time to time during the term of this Agreement.

1.5  "GNE Antigen Extension Fee" means the fee defined in Section 3.4(a).

1.6  "GNE Double Up Fee" means the fee defined in Section 3.4(b).

1.7 "GNE License Agreement(s)" means the form of GNE License Agreement 
attached as Exhibit A.

1.8  "GNE Licensed Patents" mean the following patents and patent 
applications known generally as the Cabilly patents and patent applications:

(a) U.S. Patent No. 4,816,567 and the claims relating to chimeric 
antibodies found in patents or patent applications arising from 
divisionals, continuations or continuations-in-part of any application from 
which U.S. Patent No. 4,816,567 claims priority or any substitute 
applications therefor, any patent issued with respect to any such patent 
application, any reissue, extension or patent term extension of any such 
patent, and any confirmation patent or registration patent or patent of 
addition based on any such patent  as well as the foreign counterparts of 
the foregoing and any and all reissues, reexaminations or extensions of the 
foregoing (but in any event excluding U.S.S.N. 07/205,419 and foreign 
counterparts thereof) ("Chimera Patents") and

(b)  any patent issuing based on U.S.S.N. 07/205,419 (a continuation of the 
application maturing into U.S. Patent No. 4,816,567) relating to the 
coexpression of immunoglobulin chains in recombinant host cells, as well as 
the divisionals, continuations or continuations-in-part of such U.S.S.N. 
07/205,419, the issued foreign counterparts of such U.S.S.N. 07/205,419 and 
any and all reissues, reexaminations or extensions or patent term extension 
of any such patent, and any confirmation patent or registration patent or 
patent of addition based on any such patent ("Coexpression Patents").  
Attached hereto as Exhibit B is a list of patents and patent applications
that GNE in good faith believes represents GNE Licensed Patents as of 
the Effective Date.

1.9  "GNE Licensed Product" means an Antibody with respect to which GNE has 
either significant marketing rights or has done significant development (e.g., 
created, humanized or conducted preclinical or clinical development), the 
manufacture, import, use, offer to sell or sale of which would infringe, if 
not licensed under this Agreement, one or more claims of a PDL Licensed Patent 
which have neither expired nor have been disclaimed nor have been held invalid 
or unenforceable by a court or other body of competent jurisdiction from which 
no appeal has been or may be taken.

1.10  "GNE Named Antigen(s)" means the following Antigens:  [     ].

1.11  "Opposition Proceedings" means the legal proceedings at the European 
Patent Office ("EPO") initiated against EP patent 451,216B1 and terminating at 
the decision (oral and/or written)rendered by the Opposition Division ("OD") 
of the EPO, but excluding any proceedings resulting from the filing of an 
appeal to the OD's decision.

1.12  "PDL Antigen Extension Fee" means the fee defined in Section 6.4(a).

1.13  "PDL Double Up Fee" means the fee defined in Section 6.4(b).

1.14 "PDL License Agreement(s)" means the form of PDL License Agreement 
attached as Exhibit C.

1.15  "PDL Licensed Patents" means the patents and patent applications 
identified on Exhibit D and including any applications filed as of the 
Effective Date in the United States or any foreign jurisdiction.  Licensed 
Patents shall include U.S. or foreign patents or patent applications which 
claim priority to any application to which a listed U.S. patent also claims 
priority.  PDL Licensed Patents shall also include any foreign equivalents, 
addition, continuation, continuation-in-part or division of such patents or 
patent applications or any substitute applications therefor, any patent issued 
with respect to any such patent application, any reissue, extension or patent 
term extension of any such patent, and any confirmation patent or registration 
patent or patent of addition based on any such patent.  Attached hereto as 
Exhibit D is a list of patents and patent applications that PDL in good faith 
believes represents PDL Licensed Patents as of the Effective Date.

1.16  "PDL Licensed Product" means an Antibody with respect to which PDL 
either has significant marketing rights or has done significant development 
(e.g., created, humanized or conducted preclinical or clinical development), 
the manufacture, import, use, sale or offer to sell of which would infringe, 
if not licensed under this Agreement, one or more claims of a GNE Licensed 
Patent which have neither expired or have been disclaimed nor have been held 
invalid or unenforceable by a court or other body of competent jurisdiction
from which no appeal has been or may be taken.

1.17  "PDL Named Antigen(s)" means the following Antigens:  [          ].

2.  GNE'S RIGHTS TO LICENSES

2.1  Election.  Subject to the terms and conditions of this Agreement and 
in partial consideration of the rights granted to PDL in Section 5 below, PDL 
hereby grants to GNE (a) through the period and subject to the limitation on 
the number of Antigens provided in Section 2.2, the right to receive for each 
Antigen designated by GNE, a nonexclusive, worldwide (except as provided in 
Section 3.2(a)(ii)) license under the PDL Licensed Patents to make, have made, 
use, import, offer to sell and sell Antibodies pursuant to a PDL License 
Agreement.  This right shall not extend to the PDL Named Antigens.  The rights 
of GNE under the PDL License Agreements shall include the right to grant 
sublicenses for Antibodies in accordance with the terms of the applicable PDL 
License Agreement.  Each license elected by GNE hereunder shall be pursuant to 
a separate PDL License Agreement and effective as of the date of execution by 
both parties.

2.2  Number of Licensed Antigens; Term of Rights.  

(a) Limit on Number of Antigens.  Except as provided in Section 2.2(c), 
GNE's right to obtain licenses pursuant to Section 2.1 may be exercised for 
Antibodies directed against a maximum total of six (6) Antigens.

(b) Expiration of Rights to Elect.  Except as provided in Section 2.2(c), 
GNE's right to obtain licenses pursuant to Section 2.1 shall expire on the 
[   ] anniversary of the Effective Date; provided that GNE may elect to 
extend the expiration period for each license right under Section 2.1 not 
exercised by the [    ] anniversary for an additional [        ] period by 
written notice and payment of the GNE Antigen Extension Fee to PDL prior to 
the [     ] anniversary of the Effective Date as provided in Section 
3.4(a).  

(c) Double Up Right.  Upon written notice to PDL and payment of the GNE 
Double Up Fee at any time prior to the [     ] anniversary of the Effective 
Date, GNE may elect up to an additional [     ] Antigens under Section 2.1 
for a period of [   ]  years following the date of such notice; provided 
that rights to elect licenses with respect to the first [    ] Antigens 
shall expire as of the [     ] anniversary of the Effective Date unless 
otherwise extended pursuant to Section 2.2(b).  By way of illustration and 
without limitation, if GNE elects to exercise its right hereunder but has 
exercised rights to licenses with respect to only [     ] Antigens under 
Section 2.1 as of the [     ] anniversary of the Effective Date (and has 
not extended the designation of the remaining [     ] Antigens pursuant to 
Section 2.2(b)), then the cumulative number of Antigens subject to election 
by GNE under this Agreement through the [   ]    anniversary shall be [     
] Antigens.

2.3  Procedure for Exercise of License Rights. 

GNE shall provide PDL with written notice identifying the Antigen  for 
which GNE desires to enter into a PDL License Agreement pursuant to the 
provisions of Section 2.1.  Within fifteen (15) business days of the 
written notice, GNE shall pay the applicable License Exercise Fee specified 
in Section 3.2(a).  PDL shall promptly review and respond in writing to the 
request by GNE for a license within ten (10) business days of receipt of 
the written request.  PDL may deny GNE's request for a license grant only 
if PDL has previously granted an exclusive or co-exclusive license or an 
unexpired option for an exclusive or co-exclusive license with respect to 
Antibodies to the identical Antigen or is then actively engaged in bona 
fide negotiations for such an exclusive or co-exclusive license or option 
for an exclusive or co-exclusive license; provided, however, that with 
respect to each of the GNE Named Antigens and [     ], PDL shall provide 
GNE written notice prior to entering into an exclusive or co-exclusive 
license or option with any third party with respect to that GNE Named 
Antigen and shall permit GNE the opportunity to exercise its rights under 
Section 2.1 for a period not to exceed fifteen (15) days for a license for 
such GNE Named Antigen prior to the conclusion of an agreement with such 
third party for such a license or option.  In the event that PDL denies 
GNE's request for a PDL License Agreement, GNE's right under Section 2.1 
shall not be considered exercised.  If PDL affirms GNE's request or has not 
responded within ten (10) business days of receipt of GNE's request under 
this Section 2.3(b), then GNE and PDL shall enter into a PDL License 
Agreement with respect to the Antigen.

3.  GNE'S PAYMENTS

3.1  Initial Fees.  Within ten (10) days of the Effective Date, GNE shall 
pay an initial nonrefundable, noncreditable fee of Six Million Dollars 
($6,000,000) for the right to obtain nonexclusive licenses pursuant to Section 
2.1.  In recognition of the value of the license rights hereunder attributable 
to Licensed Products that have received regulatory approval, the parties agree 
that Five Million Dollars ($5,000,000) of the Six Million Dollars ($6,000,000) 
payable under this Section 3.1 shall be considered payment attributable to the 
first license hereunder.

3.2  License Exercise Fees.  

(a) License Exercise Fee.  Within fifteen (15) business days after the 
delivery of a written notice to PDL for a nonexclusive license for 
Antibodies for one (1) Antigen under Section 2.1. GNE shall pay to PDL an 
exercise fee ("GNE License Exercise Fee") of either: 

(i) One Million Dollars ($1,000,000)[                   ]

[                   ] 

[          ] provided further that such amounts shall be increased annually
beginning January 1, 1999 and on each January 1 thereafter by an amount equal  
to the Consumer Price Index-U (or its successor) published by the U.S. Bureau 
of Labor Statistics ("CPI-U") for the prior year.  All adjustments hereunder 
shall be payable within fifteen (15) days of the publication of the CPI-U 
for the applicable year.  [               ]. All such deductions 
shall be documented with any payments made hereunder.


(b) Credits. [         ].

3.3  Annual Maintenance Fees.  Each PDL License Agreement shall provide for 
the payment to PDL of an annual maintenance fee beginning on the  [        ]
anniversary of each PDL License Agreement of either:

(a) [     ] 

(b) [      ] 

The PDL License Agreement shall further provide that annual maintenance 
fees shall be [        ] against royalties payable in the year with 
respect to which such annual maintenance fee is paid.

3.4  Antigen Extension Fee; Double Up Fee.  

(a) Antigen Extension Fee.  Concurrent with the delivery of the written 
notice of election to extend the expiration period of an exercise right 
under Section 2.2(b), GNE shall pay to PDL for each Antigen with respect to 
which GNE desires to extend such exercise period, a 
nonrefundable, noncreditable extension fee of [     ].

(b) Double Up Fee.  Concurrent with the delivery of the written notice of 
election of the "double up" right under Section 2.2(c), GNE shall pay to 
PDL a nonrefundable, noncreditable fee of  [     ].

4.  GNE'S ROYALTIES

4.1  Royalty Rates.  GNE will pay royalties to PDL under the PDL License 
Agreements at the rate of [     ] of net sales by GNE, its Affiliates and 
sublicensees and Roche of each GNE Licensed Product.  In the case of a GNE 
Licensed Product that is a bispecific antibody, to the extent a license is 
required under the PDL Licensed Patents each arm shall require a separate 
license, provided that even if two licenses are required, the bispecific 
antibody shall be considered one GNE Licensed Product and bear a royalty of [
] of net sales by GNE, its Affiliates and sublicensees and Roche of that GNE 
Licensed Product. 

4.2  Royalties to Third Parties.  GNE acknowledges and agrees that other 
licenses may be required from third parties with respect to the development, 
manufacture, use and sale of any products licensed under the PDL License 
Agreements, and that GNE shall be responsible for any royalties and other 
payments with respect to those license rights.  In no event shall GNE have a 
right to credit against, reduce or otherwise offset any royalty or payment 
obligations to such third parties against royalty amounts payable to PDL under 
the PDL License Agreements.

5.  PDL'S RIGHTS TO LICENSES

5.1  Election.  Subject to the terms and conditions of this Agreement, and 
in partial consideration of the rights granted to GNE in Section 2, GNE hereby 
grants to PDL through the period and subject to the limitation on the number 
of Antigens provided in Section 5.2, the right to receive for each Antigen 
designated by PDL, a nonexclusive, worldwide license under the GNE Licensed 
Patents to make, have made, use, import, offer to sell and sell Antibodies 
pursuant to a GNE License Agreement. This right shall not extend to the GNE 
Named Antigens.  The rights of PDL under the GNE License Agreements shall 
include the right to grant sublicenses for Antibodies in accordance with the 
terms of the applicable GNE License Agreement.  Each license elected by PDL 
hereunder shall be pursuant to a separate GNE License Agreement and effective 
as of the date of execution by both parties.

5.2  Number of Licensed Antigens; Term of Rights.  

(a) Limit on Number of Antigens.  Except as provided in Section 5.2(c), 
PDL's right to obtain licenses pursuant to Section 5.1 may be exercised for 
Antibodies directed against a maximum total of six (6) Antigens.

(b) Expiration of Rights to Elect.  Except as provided in Section 5.2(c), 
PDL's right to obtain licenses pursuant to Section 5.1 shall expire on the 
later to occur of the [    ] anniversary of the Effective Date or [     ] 
from the date of issuance in the United States of the Coexpression Patent 
(the "Expiration Date"), provided, however, that PDL may elect to extend 
the expiration period for each license right under Section 5.1 not 
exercised by the Expiration Date for an additional [   ] period by written 
notice and payment of the PDL Antigen Extension Fee to GNE prior to the 
Expiration Date as provided in Section 6.4(a).  

(c) Double Up Right.  Upon written notice to GNE and payment of the PDL 
Double Up Fee at any time prior to the Expiration Date, PDL may elect up to 
an additional [   ] Antigens under Section 5.1 for a period of  [      ] 
following the date of such notice; provided that rights to elect licenses 
with respect to the first [     ] Antigens shall expire as of the 
Expiration Date unless otherwise extended pursuant to Section 5.2(b).  By 
way of illustration and without limitation, if PDL elects to exercise its 
right hereunder but has exercised rights to licenses with respect to only [     
] Antigens under Section 5.1 as of the Expiration Date (and has not 
extended the designation of the remaining [     ] Antigens pursuant to 
Section 5.2(b)), then the cumulative number of Antigens subject to election 
by PDL under this Agreement through the [     ]  anniversary of the 
Expiration Date shall be [     ] Antigens.

5.3  Procedure for Exercise of License Rights. 

PDL shall provide GNE with written notice identifying the Antigen  for 
which PDL desires to enter into a GNE License Agreement pursuant to the 
provisions of Section 5.1.  Within fifteen (15) business days of the 
written notice, PDL shall pay the applicable License Exercise Fee specified 
in Section 6.2.  GNE shall promptly review and respond in writing to the 
request by PDL for a license within ten (10) business days of receipt of 
the written request.  GNE may deny PDL's request for a license grant only 
if GNE has previously granted an exclusive or co-exclusive license or an 
unexpired option for an exclusive or co-exclusive license with respect to 
Antibodies to the identical Antigen to either (a) a non-affiliate or (b) 
Roche under that certain agreement dated October 15, 1995, as such 
agreement is in effect on the Effective Date, or is then actively engaged 
in bona fide negotiations for such an exclusive or co-exclusive license or 
option for an exclusive or co-exclusive license; provided, however, that 
with respect to each of the PDL Named Antigens and [     ], GNE shall 
provide PDL written notice prior to entering into an exclusive or co-
exclusive license or option with any third party with respect to that PDL 
Named Antigen and shall permit PDL the opportunity to exercise its rights 
under Section 5.1 for a period not to exceed fifteen (15) days for a 
license for such PDL Named Antigen prior to the conclusion of an agreement 
with such third party for such a license or option.  In the event that GNE 
denies PDL's request for a GNE License Agreement, PDL's right under Section 
5.1 shall not be considered exercised.  If GNE affirms PDL's request or has 
not responded within ten (10) business days of receipt of PDL's request 
under this Section 5.3, then PDL and GNE shall enter into a GNE License 
Agreement with respect to the Antigen.

6.  PDL'S PAYMENTS

6.1  Initial Fees.  Within ten (10) days of the Effective Date, PDL shall 
pay (a) an initial nonrefundable, noncreditable fee of One Million Dollars 
($1,000,000) for the right to obtain nonexclusive licenses pursuant to Section 
5.1.

6.2  License Exercise Fee.  Within fifteen (15) business days after the 
delivery of a written notice to GNE for a nonexclusive license for Antibodies 
for one (1) Antigen under Section 5.1, PDL shall pay to GNE an exercise fee 
("PDL License Exercise Fee") of : 

(i) Five Hundred Thousand Dollars ($500,000) for a license under the 
Chimera Patents; and/or 

(ii) Five Hundred Thousand Dollars ($500,000) for a license under the 
Coexpression Patents.

provided further that such amounts shall be increased annually beginning 
January 1, 1999 and on each January 1 thereafter by an amount equal to the 
CPI-U.  All adjustments hereunder shall be payable within fifteen (15) days 
of the publication of the CPI-U for the applicable year. 

6.3  Annual Maintenance Fees.  Each GNE License Agreement shall provide for 
the payment to GNE of an annual maintenance fee beginning on the [     ] 
anniversary of each GNE License Agreement of:

(a) [     ] under the license for the Chimera Patents; and/or

(b) [     ] under the license for the Coexpression Patents.

The GNE License Agreement shall further provide that annual maintenance 
fees shall be fully creditable against royalties payable in the year with 
respect to which such annual maintenance fee is paid. 

6.4  Antigen Extension Fee; Double Up Fee.  

(a) Antigen Extension Fee.  Concurrent with the delivery of the written 
notice of election to extend the expiration period of an exercise right 
under Section 5.2(b), PDL shall pay to GNE for each Antigen with respect to 
which PDL desires to extend such exercise period, a nonrefundable, 
noncreditable extension fee of [     ].

(b) Double Up Fee.  Concurrent with the delivery of the written notice of 
election of the "double up" right under Section 5.2(c), PDL shall pay to 
GNE a nonrefundable, noncreditable fee of [     ].

7. PDL'S ROYALTIES

7.1  Royalty Rates. PDL will pay royalties to GNE under the GNE License 
Agreements at the rate of [     ] of net sales by PDL, its Affiliates and 
sublicensees of each PDL Licensed Product.  In the case of a PDL Licensed 
Product that is a bispecific antibody, to the extent a license is required 
under the PDL Licensed Patents each arm shall require a separate license, 
provided that even if two licenses are required, the bispecific antibody shall 
be considered one PDL Licensed Product and bear a royalty of [     ] of net 
sales by PDL, its Affiliates and Designees of that PDL Licensed Product.

7.2  Royalties to Third Parties. PDL acknowledges and agrees that other 
licenses may be required from third parties with respect to the development, 
manufacture, use and sale of any products licensed under the GNE License 
Agreements, and that PDL shall be responsible for any royalties and other 
payments with respect to those license rights.  In no event shall PDL have a 
right to credit against, reduce or otherwise offset any royalty or payment 
obligations to such third parties against royalty amounts payable to GNE under 
the GNE License Agreements.

8.  REPRESENTATIONS, DISCLAIMERS

8.1  Representations of PDL.  PDL represents and warrants to GNE that:

(a)  The execution, delivery and performance of this Agreement by PDL will 
not, with or without notice, the passage of time or both, result in any 
violation of, be in conflict with, or constitute a default under any 
material contract, obligation or commitment to which PDL is a party or by 
which it is bound, or to PDL's knowledge, violate any statute, rule or 
governmental regulation applicable to PDL.

(b)  PDL has all requisite legal and corporate power and authority to enter 
into this Agreement and to carry out and perform its obligations under the 
terms of this Agreement.

(c)  The PDL Licensed Patents constitute all of the patents and 
patent applications owned by PDL as of the Effective Date which  relate 
generally to the humanization of antibodies.

8.2  Representations of GNE.  GNE represents and warrants to PDL that:

(a)  The execution, delivery and performance of this Agreement by GNE will 
not, with or without notice, the passage of time or both, result in any 
violation of, be in conflict with, or constitute a default under any 
material contract, obligation or commitment to which GNE is a party or by 
which it is bound, or to GNE's knowledge, violate any statute, rule or 
governmental regulation applicable to GNE.

(b)  GNE has all requisite legal and corporate power and authority to enter 
into this Agreement and to carry out and perform its obligations under the 
terms of this Agreement. 

(c)  With the exception of [     ] (including any divisionals, 
continuations or continuations-in-part of such applications, the issued 
foreign counterparts of such applications and any and all reissues, 
reexaminations or extensions or patent term extension of any such patent, 
and any confirmation patent or registration patent or patent of addition 
based on any such patent), the GNE Licensed Patents constitute all of the 
patents and patent applications owned by GNE as of the Effective Date which 
relate generally to chimeric and/or humanized antibodies and to the 
coexpression of immunoglobulin chains in recombinant host cells. 

8.3  No Warranty of Validity, Non-Infringement.  Nothing in this Agreement 
shall be construed as (a) a warranty or representation by PDL as to the 
validity or scope of any PDL Licensed Patents; (b) a warranty or 
representation by GNE as to the validity or scope of any GNE Licensed Patents; 
or (c) a warranty or representation that anything made, used, sold or 
otherwise disposed of under any PDL License Agreement or GNE License Agreement 
is or will be free from infringement of patents, copyrights, trademarks, trade 
secrets or other rights of third parties.

8.4  Disclaimer of Warranties.  EXCEPT AS SPECIFICALLY SET FORTH IN 
SECTIONS 8.1 AND 8.2 ABOVE, NEITHER PDL NOR GNE MAKE TO THE OTHER ANY 
REPRESENTATIONS OR EXTEND ANY WARRANTIES OF ANY KIND, EITHER EXPRESS OR 
IMPLIED.  FURTHER, NEITHER PDL NOR GNE MAKE TO THE OTHER ANY IMPLIED 
WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OR THAT 
PRACTICE UNDER ITS LICENSED PATENTS UNDER A LICENSE AGREEMENT WILL NOT 
INFRINGE ANY THIRD PARTY RIGHTS.

9.  CONFIDENTIALITY; DISCLOSURE

9.1  Prior Agreement.  This Agreement supersedes any and all previous 
agreements and understandings, whether oral or written, between the parties 
regarding the treatment of confidential information, including without 
limitation that certain Confidentiality Agreement entered into between PDL and 
GNE as of September 4, 1997.

9.2  Confidentiality.  During the term of this Agreement and for a period 
of five (5) years following expiration or termination of this Agreement, each 
party shall maintain in confidence all information and materials disclosed by 
the other party in writing and marked as confidential or disclosed orally or 
otherwise and which has been denominated in writing by the disclosing party to 
be confidential within 30 days after such disclosure, including, without 
limitation, information relating to the PDL Licensed Patents or GNE Licensed 
Patents, PDL Licensed Products or GNE Licensed Products, and the business 
plans of the other party, including information provided by either party to 
the other party prior to the Effective Date, and shall not use such trade 
secrets or proprietary information for any purpose except as permitted by this 
Agreement or disclose the same to anyone other than those of its Affiliates, 
sublicensees, employees, consultants, agents or subcontractors as are 
necessary in connection with such party's activities as contemplated in this 
Agreement.  Each party shall obtain an appropriate enforceable agreement from 
any sublicensees, employees, consultants, agents and subcontractors, prior to 
disclosure, to hold in confidence and not make use of such trade secrets or 
proprietary information for any purpose other than those permitted by this 
Agreement. 

9.3  Exceptions.  The obligation of confidentiality contained in this 
Agreement shall not apply to the extent that (a) either party (the 
"Recipient") is required to disclose information by order or regulation of a 
governmental agency or a court of competent jurisdiction, provided that the 
Recipient shall not make any such disclosure (other than a filing of 
information or materials with the U.S. Securities and Exchange Commission made 
with a request for confidential treatment for portions of such material for 
which such treatment may reasonably be expected to be granted) without first 
notifying the other party and allowing the other party a reasonable 
opportunity to seek injunctive relief from the obligation to make such 
disclosure or (b) the Recipient can demonstrate that (i) the disclosed 
information was at the time of such disclosure to the Recipient already in the 
public domain other than as a result of actions of the Recipient, its 
Affiliates, employees, sublicensees, agents or subcontractors in violation 
hereof; (ii) the disclosed information was rightfully known by the Recipient 
or its Affiliates (as shown by its written records) prior to the date of 
disclosure to the Recipient in connection with the negotiation, execution or 
performance of this Agreement; or (iii) the disclosed information was received 
by the Recipient or its Affiliates on an unrestricted basis from a source 
unrelated to any party to this Agreement and not under a duty of 
confidentiality to the other party, (c) disclosure is made to a government 
regulatory agency as part of such agency's biological product license approval 
process or (d) the amount of royalties paid or received is disclosed in a 
party's financial statements or reports.

9.4  Public Disclosure.  The parties will issue a press release concerning 
the parties' entry into this Agreement in the form attached hereto as Exhibit 
E.  Other than the foregoing and except as required by law or regulation, 
neither party shall publicly disclose the terms and conditions of this 
Agreement unless expressly authorized to do so by the other party, which 
authorization shall not be unreasonably withheld.  In the event that 
disclosure shall be agreed upon then the parties will work together to develop 
a mutually acceptable disclosure.  In any event, each party shall be entitled 
to identify the number of licenses with respect to which a party has exercised 
its rights hereunder, licensed Antigens if such Antigens have been previously 
publicly identified, and the number of Antigens with respect to which a party 
may obtain a license hereunder.

10.  TERM AND TERMINATION

10.1  Term.  Unless earlier terminated in accordance with this Article 10, 
this Agreement shall remain in effect until the expiration of the last GNE 
License Agreement or PDL License Agreement.

10.2 Default.  If either party defaults in the performance of, or fails to 
be in compliance with, any material agreement, condition or covenant of this 
Agreement, the party not in default may provide notice of such default to the 
defaulting party.  The provisions for resolution of a default are limited to 
those set forth in Section 11.6 below.

10.3  Rights and Obligations Upon Termination or Expiration.  Upon 
expiration or termination of this Agreement for any reason, nothing herein 
shall be construed to release either party from any obligation that matured 
prior to the effective date of such termination.  In addition, the obligations 
set forth in Articles 9 and 11 shall survive the expiration or termination of 
this Agreement.  Upon termination of this Agreement, each party shall return 
to the other party any Confidential Information disclosed by the other party 
under this Agreement.   

11.  MISCELLANEOUS

11.1  Assignment.  This Agreement may not be assigned by either party 
without the prior written consent of the other, except that either may assign 
this Agreement without consent to a party which acquires all or substantially 
all of that portion of the business to which this Agreement pertains, whether 
by merger, sale of assets or otherwise.  A merger or consolidation shall be 
deemed to constitute an assignment.

11.2  Entire Agreement; Amendment.  This Agreement, including Exhibits 
hereto, constitutes the entire agreement between the parties hereto with 
respect to the within subject matter and supersedes all previous agreements, 
whether written or oral.  This Agreement shall not be changed or modified 
orally, but only by an instrument in writing signed by both parties.

11.3  Severability.  If any provision of this Agreement is declared invalid 
by any court of competent jurisdiction from which an appeal is not taken 
within the time provided by law, then and in such event, this Agreement will 
be deemed to have been terminated only as to the portion thereof which relates 
to the provision invalidated by that decision and only in the relevant 
jurisdiction, but this Agreement, in all other respects and all other 
jurisdictions, will remain in force; provided, however, that if the provision 
so invalidated is essential to this Agreement as a whole, then the parties 
shall negotiate in good faith to amend the terms hereof as nearly as practical 
to carry out the original interest of the parties.  

11.4  Notices.  Any notice or report required or permitted to be given 
under this Agreement shall be in writing and shall be sent by express courier 
or facsimile and confirmed by mailing, as follows (or at such other address as 
PDL or GNE shall have furnished to the other in writing) and shall be 
effective three (3) days business after such mailing:

        If to PDL:              Protein Design Labs, Inc.
                                34801 Campus Drive
                                Fremont, CA 94555  
                                Attention:  General Counsel

                                Facsimile number:  (510) 574-1500

        If to GNE:              Genentech, Inc.
                                1 DNA Way       
                                South San Francisco, CA  94080
                                Attention:  Corporate Secretary

                                Facsimile number:  (650) 225-8654

11.5  Choice of Law.  The validity, performance, construction, and effect 
of this Agreement and any arbitration conducted under section 11.6 below shall 
be governed by the laws of the State of California which are applicable to 
contracts between California residents to be performed wholly within 
California.

11.6  Dispute Resolution.

(a)  Negotiations.  Any dispute, controversy or claim arising out of or 
relating to any provision of this Agreement or a GNE License Agreement or a 
PDL License Agreement or the interpretation, enforceability, performance, 
breach, termination or validity hereof or thereof, including without 
limitation, this dispute resolution provision, shall be subject to the 
procedures set forth in this Section 11.6.  A designated representative of 
PDL and GNE will meet as reasonably requested by either party to review any 
dispute, controversy or claim arising out of or relating to any provision 
of this Agreement or a GNE License Agreement or a PDL License Agreement.  
If the disagreement is not resolved by the designated representatives by 
mutual agreement within thirty (30) days after a meeting to discuss the 
disagreement, either party may at any time thereafter provide the other 
written notice specifying the terms of such disagreement in reasonable 
detail.  Upon receipt of such notice, the chief executive officers of PDL 
and GNE shall meet at a mutually agreed upon time and location for the 
purpose of resolving such disagreement.  They will discuss the problems 
and/or negotiate for a period of up to sixty (60) days in an effort to 
resolve the disagreement or negotiate an acceptable interpretation or 
revision of the applicable portion of this Agreement mutually agreeable to 
both parties, without the necessity of formal procedures relating thereto.  
During the course of such negotiations, the parties will reasonably 
cooperate and provide information that is not materially confidential in 
order that each of the parties may be fully informed with respect to the 
issues in dispute.  The institution of a formal legal proceeding under 
Section 11.6(a) or (b) to resolve the disagreement may occur by written 
notice to the other party only after the earlier of: (a) the chief 
executive officers mutually agreeing that resolution of the disagreement 
through continued negotiation is not likely to occur, or (b) following 
expiration of the sixty (60) day negotiation period.  Participation in the 
Opposition Proceedings shall not be subject to the provisions of this 
Section 11.6.

(b)  Arbitration.  Subject to Section 11.6(a), any dispute, controversy or 
claim arising out of or in connection with or relating to this Agreement or 
the breach or alleged breach thereof, but not including any dispute, 
controversy or claim concerning the validity of any GNE Licensed Patent or 
PDL Licensed Patent, shall be submitted by the parties to arbitration in 
Santa Clara County, California in accordance with the then-current 
commercial arbitration rules of the American Arbitration Association 
("AAA") except as otherwise provided herein.  If the dispute, controversy 
or claim concerns the validity of any GNE Licensed Patent or PDL Licensed 
Patent, all matters subject to dispute, controversy or claim hereunder 
shall be removed to Federal District Court as provided in Section 11.6(c).

Any arbitration proceeding hereunder shall be held in English and a 
transcribed record prepared in English.  The parties shall choose, by 
mutual agreement, one (1) neutral arbitrator within thirty (30) days of 
receipt of notice of the intent to arbitrate.  If no arbitrator is 
appointed within the times herein provided or any extension of time which 
is mutually agreed upon, the AAA shall make such appointment of a person 
who shall devote substantial time to arbitrating within thirty (30) days of 
such failure.  Discovery permitted by the arbitrator shall be pursuant to 
California Code of Civil Procedure Sections 1283.05 and 1283.1, provided 
that all discovery shall be completed within sixty (60) days of the 
appointment of such arbitrator and the decision rendered by such arbitrator 
shall thereafter be delivered in writing setting forth the basis therefor 
within thirty (30) days after the completion of discovery.  The award 
rendered by the arbitrator shall include costs of arbitration, reasonable 
attorneys' fees and reasonable costs for expert and other witnesses, and 
judgment on such award may be entered in any court having jurisdiction 
thereof.  Nothing in this Agreement shall be deemed as preventing either 
party from seeking injunctive relief (or any other provisional remedy) from 
any court having jurisdiction over the parties and the subject matter of 
the dispute but only to the extent necessary to protect either party's 
name, proprietary information, trade secrets, know-how or any other similar 
proprietary rights.  If the issues in dispute involve scientific or 
technical matters related to monoclonal antibody technology, any arbitrator 
chosen hereunder shall have not less than five (5) years of educational 
training and/or experience sufficient to demonstrate a reasonable level of 
relevant scientific and/or technical knowledge related to monoclonal 
antibody technology.  If the issues in dispute involve patent matters 
(other than validity of a GNE Licensed Patent or PDL Licensed Patent), then 
such arbitrator shall also be a licensed patent attorney or otherwise 
knowledgeable about patent law matters and to the extent possible, with 
monoclonal antibody technology.  The decision of the arbitrator shall be in 
writing and shall set forth the basis therefor.  The arbitrator shall have 
the authority to award such remedies as he or she believes appropriate in 
the circumstances, including, but not limited to, compensatory damages 
subject to the Three Percent (3%) royalty maximum set forth herein, 
consequential and incidental damages, interest, tort damages (but not 
punitive or similar damages) and specific performance and other equitable 
relief.

(c)  Patent Validity.  Subject to Section 11.6(a), any dispute, controversy 
or claim (i) which involves the validity of a GNE Licensed Patent or PDL 
Licensed Patent issued in the United States shall be subject to actions 
before the United States Patent and Trademark Office and/or adjudicated in  
Federal District Court, Central District, Santa Clara County in the State 
of California and (ii) which involves the validity of a GNE Licensed Patent 
or PDL Licensed Patent issued in any other country shall be brought before 
an appropriate regulatory or administrative body or court in that country.  
The prevailing party shall be entitled to recover from the other party, the 
reasonable attorneys' fees, costs and expenses incurred by such prevailing 
party in connection with any action or proceeding under this Section 
11.6(c).

11.7  Waiver.  The failure of either party to assert a right hereunder or 
to insist upon compliance with any term or condition of this Agreement shall 
not constitute a waiver of that right or excuse a similar subsequent failure 
to perform any such term or condition by the other party.  None of the terms, 
covenants and conditions of this Agreement can be waived except by the written 
consent of the party waiving compliance.

11.8  Headings.  The captions used herein are inserted for convenience of 
reference only and shall not be construed to create obligations, benefits, or 
limitations.

11.9  Counterparts.  This Agreement may be executed in counterparts, all of 
which taken together shall be regarded as one and the same instrument.  
Execution and delivery of this Agreement by exchange of facsimile copies 
bearing the facsimile signature of a party hereto shall constitute a valid and 
binding execution and delivery of this Agreement by such party.  Such 
facsimile copies shall constitute enforceable original documents.

IN WITNESS WHEREOF, the parties have executed this Agreement as of the date 
first written above.

PDL:                                                GNE:

Protein Design Labs, Inc.                           Genentech, Inc.

By /s/  Laurence Jay Korn                           By /s/  Arthur Levinson

Title   Chairperson & CEO                           Title   President  & CEO



Exhibits

Exhibit A- Form of GNE License Agreement 

Exhibit B- GNE Licensed Patents 

Exhibit C - Form of PDL License Agreement 

Exhibit D - PDL Licensed Patents

Exhibit E - Form of Joint Press Release

Exhibit A

Form of GNE License Agreement

Confidential Treatment Requested

GNE LICENSE AGREEMENT

This GNE License Agreement ("Agreement"), dated as of                   
                , is between Genentech, Inc., a Delaware corporation, having a 
principal place of business at 1 DNA Way, South San Francisco, California 
94080 (hereinafter "GNE") and Protein Design Labs, Inc., a Delaware 
corporation, having a place of business at 34801 Campus Drive, Fremont, 
California 94555 (hereinafter "PDL").

WHEREAS:

A.  GNE and PDL have entered into a Patent Licensing Master Agreement 
effective September __, 1998 (the "Master Agreement"), pursuant to which PDL 
may enter into this Agreement  with respect to a license under either or both 
of the Chimera Patents or Coexpression Patents (as defined below), commonly 
referred to as the "Cabilly Patents," for PDL's antibody products and 
services. 

B.      The Master Agreement provides PDL with the right to obtain a 
nonexclusive, worldwide, royalty-bearing license under the Cabilly Patents 
under the terms and conditions of this Agreement. 

        NOW, THEREFORE, the parties agree as follows:

Article I

DEFINITIONS

All references to Exhibits, Articles and Sections shall mean the 
Exhibits to, and Articles and Sections of, this Agreement, unless otherwise 
specified.  Unless otherwise specifically set forth herein, the following 
terms shall have the following meanings:

1.01. "Affiliate" means any corporation or other business entity 
controlled by, controlling, or under common control with another entity, with 
"control" meaning direct or indirect beneficial ownership of more than fifty 
percent (50%) of the voting stock of such corporation, or more than a fifty 
percent (50%) interest in the decision-making authority of such other 
unincorporated business entity; and a corporation in which the maximum amount 
of stock permitted by law to be held by another entity is beneficially owned 
by such other entity.  

1.02.  "Antibody" means any antibody directed against an Antigen and 
shall include, without limitation, monospecific and bispecific antibodies (but 
only with respect to the Antigen for a bispecific antibody); less than full-
length antibody forms such as Fv, Fab, and F(ab')2; single-chain antibodies, 
and antibody conjugates bound to a toxin, label or other moiety, as well as 
any and all such constructs directed against the Antigen.

1.03.  "Antigen" means the target molecule: _____________________.   

1.04.  "Bulk Product" means Licensed Product supplied in a form other 
than Finished Product which can be converted into Finished Product.

1.05. "Combination Product(s)" means any product containing both a 
pharmaceutically active agent or ingredient which constitutes a Licensed 
Product and one or more other pharmaceutically active agents or ingredients 
which do not constitute Licensed Products.

1.06.  "Designee" means a Sublicensee or other person or entity 
designated by a Party to exercise the rights of and perform obligations 
hereunder in place of that Party in the Territory or a portion thereof.

1.07. "Effective Date" means the date of this Agreement as set forth 
above. 

1.08.  "Finished Product" means any and all Licensed Products in form 
for use by an end user and not intended for further chemical or genetic 
manipulation or transformation.

1.09.  "Licensed Patents" means either or both of the following, as 
elected by PDL pursuant to Section 2.01 hereof and set forth on Exhibit A 
known generally as the Cabilly patents and patent applications:

(a) U.S. Patent No. 4,816,567 and the claims relating to chimeric 
antibodies found in patents or patent applications arising from 
divisionals, continuations or continuations-in-part of any 
application from which U.S. Patent No. 4,816,567 claims 
priority or any substitute applications therefor, any patent 
issued with respect to such patent application, any reissue, 
extension or patent term extension of any such patent, and any 
confirmation patent or registration patent or patent of 
addition based on any such patent as well as the foreign 
counterparts of the foregoing (but in any event excluding 
U.S.S.N. 07/205,419 and foreign counterparts thereof) ("Chimera 
Patents") and

(b) any patent issuing based on U.S.S.N. 07/205,419 (a 
continuation of the application maturing into U.S. Patent No. 
4,816,567) relating to the coexpression of immunoglobulin 
chains in recombinant host cells, as well as the divisionals, 
continuations or continuations-in-part of such U.S.S.N. 
07/205,419, the issued foreign counterparts of such U.S.S.N. 
07/205,419 and any and all reissues, reexaminations or 
extensions or patent term extension of any such patent, and any 
confirmation patent or registration patent or patent of 
addition based on any such patent ("Coexpression Patents"). 

1.10.  "Licensed Product(s)" means an Antibody with respect to which PDL 
has either significant marketing rights or has done significant development 
(e.g., created, humanized or conducted preclinical or clinical development), 
the manufacture, import, use, offer to sell or sale of which would infringe, 
if not licensed under this Agreement, a Valid Claim. 

1.11.  "Net Sales" means the gross invoice or contract price to third 
party customers for Finished Products.  Finished Products used or
consumed by PDL or its Affiliates or Designees as part of the delivery 
of services to customers shall be considered Net Sales at the gross 
invoice or contract price of like Finished Products which are sold to 
customers. If Licensed Product is sold in combination with one or more
active ingredients, Net Sales shall be calculated by multiplying Net Sales
of the Combination Product by the fraction A/(A+B) where A is the
sales price of the Finished Product in the Combination Product 
when sold separately and B is the total sales price of all other active 
ingredients in the Combination Product when sold separately.  If the Finished 
Product and the other active ingredients are not sold separately, the portion 
of the total cost of the Combination Product attributed to Finished Product 
shall be a fraction, the numerator of which shall be the cost of the Finished 
Product and the denominator of which shall be the total cost of the 
Combination Product.  The fraction shall be multiplied times the sales price 
of the Combination Product to arrive at Net Sales.  For all Licensed Product 
used or consumed by others than PDL, PDL shall be entitled to deduct [       ] 
from Net Sales in lieu of all other deductions such as taxes, shipping 
charges, allowances and the like prior to calculating royalties due. If PDL or 
any of its Affiliates or Sublicensees receive non-cash consideration for any 
Licensed Product sold or otherwise transferred to an independent third party 
not an Affiliate of the seller or transferor, the fair market value of such 
non-cash consideration on the date of such transfer as known to PDL, or as 
reasonably estimated by PDL if unknown, shall be included in the definition of 
Net Sales.  Net Sales shall not include Licensed Product provided for bona 
fide clinical trial, evaluation, research or development purposes.

Net Sales for Bulk Products shall be calculated by multiplying the units 
of Finished Product to which such Bulk Product is reasonably anticipated to be 
converted by the established market price of the Finished Product on the date 
of sale of the Bulk Product.  By way of example and without limitation, units 
of Finished Product may be measured in grams or doses, as appropriate.

The method of calculating Net Sales of materials in form other than 
Finished Product or Bulk Product that can be converted into Finished Product 
shall be established by the Parties prior to the first sale or transfer of any 
such material by PDL to a non-affiliated third party.

1.12.  "Party" means GNE or PDL and when used in the plural shall mean 
GNE and PDL.

1.13.  "Sublicensee" means any person or entity granted a sublicense by 
PDL under this Agreement.

1.14.  "Territory" means worldwide.

1.15.  "Valid Claim" means any claim in any Licensed Patents which claim 
has neither expired or been disclaimed nor has been held invalid or 
unenforceable by a court or other body of competent jurisdiction from which no 
appeal has been or may be taken.

Article II

GRANT

2.01.  License.  With respect to each Licensed Product, PDL shall 
provide written notice to GNE of its election to have either or both of the 
Chimera Patents and/or Coexpression Patents designated as Licensed Patents 
hereunder, and the Licensed Patents elected by PDL shall be specified in 
Exhibit A.  Subject to the fulfillment by PDL of all the terms and conditions 
of this Agreement, GNE hereby grants to PDL and PDL hereby accepts a 
nonexclusive license, together with the right to sublicense, under Licensed 
Patents for the term thereof  to make, have made, use, import, offer to sell 
and sell Licensed Products in the Territory. GNE shall be free at its 
discretion to enter into agreements with additional licensees at any time and 
on terms solely of its choosing.

2.02.  Right to Appoint Designee.  PDL shall have the right to 
sublicense all of its rights hereunder for all or part of the Territory 
(including on a country-by-country basis) to one or more Designees of its 
choosing, provided that PDL agrees that it will indemnify GNE for any failure 
of performance on the part of such Designee.  An entity that simply acts to 
co-promote or to co-market a Licensed Product supplied by PDL shall not be 
considered a Designee and PDL may co-promote or co-market such Licensed 
Product with such entity in a given country or countries, provided that PDL 
shall be responsible for the payment of royalties on Net Sales of Licensed 
Products by such entity and for all other acts of such entity as if such acts 
were those of the PDL.  Promptly following the execution of any sublicense 
hereunder, PDL shall notify GNE of the identity of the Designee and the scope 
of the sublicense.

2.03.  No Other License.  PDL understands and agrees that no license 
under any patent or application other than Licensed Patents is or shall be 
deemed to have been granted under this Agreement, either expressly or by 
implication.

2.04  Updates to List of Licensed Patents. A list of all Chimera and 
Coexpression Patents is set forth on Exhibit B attached hereto.  Exhibit B is 
a list of patents and patent applications that GNE in good faith believes 
represents the Chimera and Coexpression Patents as of the Effective Date.  
Upon written request of PDL (which request shall not be made more than once 
per calendar year), GNE agrees to provide a written update listing the 
Licensed Patents, and such update shall constitute an amendment to Exhibit B. 
 GNE may, at its option, furnish such update to PDL from time to time during 
the term of this Agreement as part of an update to the Master Agreement. 
Article III

FEES AND ROYALTIES

3.01  License Exercise Fee.  Within fifteen (15) business days after 
the Effective Date of this Agreement, PDL shall pay to GNE a non-creditable, 
non-refundable license exercise fee of [One Million United States Dollars (US 
$1,000,000) for a license under the Chimera and 
Coexpression Patents][      ] for a license under the [Chimera] [Coexpression] 
Patents]. [Drafting note:  Amount will depend on whether PDL takes a
license under the Chimera Patents, the Coexpression Patents, or both.]
Such amounts shall be increased annually beginning on January 1,
1999 and on each January 1 thereafter by an amount equal to the Consumer
 Price Index-U (or its successor) published by the U.S. Bureau of Labor
Statistics ("CPI-U") for the prior year. 

3.02.  Annual Maintenance Fees.  In further consideration of the license 
granted in Article II, within fifteen (15) business days of the [     ] 
anniversary of the Effective Date and each anniversary thereafter, PDL shall 
pay to GNE a nonrefundable annual maintenance fee of [     ] under the license 
for the Chimera and Coexpression Patents] [     ] under the license for the 
[Chimera] [Coexpression] Patents]. [Drafting note:  Amount will depend on 
whether PDL takes a license under the Chimera Patents, the Coexpression 
Patents, or both.]  The annual maintenance fees paid by PDL hereunder shall be 
fully creditable against royalties payable for the year with respect to which 
such annual maintenance fees are paid. 

3.03.  Earned Royalties.  In further consideration of the rights and 
licenses granted under Article II, PDL shall pay to GNE a royalty of [     ] 
of Net Sales of Licensed Products sold by PDL, its Affiliates and its 
Sublicensees under the Licensed Patents in each country in the Territory until 
the later of the last date on which there is a Valid Claim that, but for the 
licenses granted to PDL under this Agreement, would be infringed by the 
making, using, importation, having made, offering for sale or sale of that 
Licensed Product in such country in the Territory or by the manufacture of 
Licensed Product in the country of manufacture. [Drafting Note:  Include the 
following sentence if the licensed Antibody is a bispecific antibody:  "If the 
Antigen is the target of one arm of a bispecific antibody, then both arms 
shall be considered one Licensed Product for purposes of calculating royalties 
with respect to such Licensed Product, and PDL shall pay a royalty of [     ] 
of Net Sales by PDL, its Affiliates and Designees."] 

3.04.  Sales To and Between Affiliates, Etc.  No royalties shall be due 
upon sales of Licensed Products by and between PDL, its Affiliates, its 
Designees, co-promoting parties or co-marketing parties as permitted under 
Section 2.02; provided, however, that the royalty hereunder shall be payable 
upon the final sale of such Licensed Product by any of the foregoing to a non-
Affiliate.

3.05  Royalties to Third Parties.  PDL acknowledges and agrees that 
other licenses may be required from third parties with respect to the 
development, manufacture, importation, use, and sale of any Licensed Product 
under this Agreement, and that PDL shall be responsible for any royalties and 
other payments with respect to those license rights.  In no event shall PDL 
have a right to credit against, reduce or otherwise offset any royalty or 
payment obligations to such third parties against royalty amounts payable to 
GNE under the this Agreement.

Article IV

RECORDS, REPORTS AND PAYMENTS

4.01.  Records Retention.  PDL shall keep and shall cause its 
Sublicensees to keep records of the sales of all Licensed Products in 
sufficient detail to permit GNE to confirm the accuracy of PDL's royalty 
calculations for a period of at least three (3) years after each reporting 
period in which Net Sales occur.  At GNE's request and expense not more than 
once per year, PDL shall permit an independent certified public accountant 
appointed by GNE and acceptable to PDL to examine, upon reasonable notice and 
at reasonable times, such records solely to the extent necessary to verify 
PDL's calculations.  Such examination shall be limited to a period of time no 
more than three (3) years immediately preceding the request for examination.  
If PDL's royalties are found to be in error such that royalties to GNE were 
underpaid then PDL shall promptly pay any deficiency, plus interest at the 
prime rate, to GNE and if the deficiency is more than [     ] then PDL shall 
reimburse GNE for its costs in examining such records.  Any overpayment by PDL 
will be promptly corrected by a refund.

4.02.  Reports.  Within sixty (60) days after the end of  each calendar 
quarter following PDL's or its Designee's first commercial sale of a Licensed 
Product, PDL shall furnish to GNE a written report of all sales of Licensed 
Products subject to royalty under Section 3.03 during the calendar quarter 
most recently ended, provided that reports with respect to sales by Designees 
shall include only those sales for which royalty reports were received by PDL 
during such calendar quarter. Such report shall include (i) the determination 
of Net Sales as specified in Section 1.11; and (ii) the royalty payment then 
due by PDL to GNE.  PDL agrees to notify GNE in writing within sixty (60) days 
after the date on which PDL, its Affiliates or Sublicensees obtain marketing 
approval of a Licensed Product in any country in the Territory.  Such notice 
shall specify the country in which marketing approval was obtained and the 
date of such approval. 

4.03  Payments.  Concurrently with each report pursuant to Section 4.02, 
PDL shall make the royalty payment then due.  Payments shall be in United 
States dollars and, unless otherwise agreed in writing, shall be made by wire 
transfer to such bank as GNE may from time to time designate in writing, 
without set-off and free and clear of and without any deduction or withholding 
for or on account of any taxes, duties, levies, imposts, fees or charges 
except for withholding required by tax authorities for income or withholding 
taxes on royalties actually payable to GNE.  PDL shall make any withholding 
payments due on behalf of GNE and shall promptly provide GNE with official tax 
receipts or other written documentation sufficient to enable GNE to satisfy 
the United States tax authorities with respect to GNE's application for a 
foreign tax credit for such payment.  GNE agrees to reasonably cooperate with 
PDL in obtaining a refund of any withholding taxes or levies paid by PDL, if 
any, with respect to any payments to GNE hereunder.  In the event that GNE is 
successful in obtaining any refund of tax withholding amounts paid by PDL 
under this Agreement, GNE agrees to promptly remit such refund amount to PDL. 
 PDL shall be liable for interest on any overdue royalties at the rate of ten 
percent (10%) per annum, or the highest rate allowed by law, whichever is 
less, commencing on the date such royalties are due until paid.

4.04.  Currency Conversion.  Royalties due on Net Sales of Licensed 
Products made in currency other than United States dollars shall first be 
calculated in the foreign currency and then converted to United States dollars 
using the average of the daily exchange rates for such currency quoted by 
Citibank, N.A. for each of the last five (5) banking days of each calendar 
quarter.  

Article V

LIABILITY, REPRESENTATIONS

5.01.  Indemnification.  PDL shall defend, indemnify and hold GNE 
harmless against any and all liability, damage, loss, cost or expense 
resulting from any third party claim, suit or other action arising out of or 
based on the manufacture, use or sale of any Licensed Product by PDL, its 
Sublicensees or co-promoting or co-marketing entities pursuant to Section 
2.02; provided, however, that GNE shall promptly notify PDL of such claim or 
action and PDL, at PDL's cost, shall have sole control over the defense, 
including any settlement of any claim or action, with full cooperation from 
GNE.  

5.02.  Representations of GNE.  GNE represents and warrants to PDL that:

(a)  The execution, delivery and performance of this Agreement by 
GNE will not, with or without notice, the passage of time or 
both, result in any violation of, be in conflict with, or 
constitute a default under any material contract, obligation or 
commitment to which GNE is a party or by which it is bound, or 
to GNE's knowledge, violate any statute, rule or governmental 
regulation applicable to GNE.

(b)  GNE has all requisite legal and corporate power and authority 
to enter into this Agreement on behalf of itself and its 
Affiliates and to carry out and perform its obligations under 
the terms of this Agreement.


5.03.  Representations of PDL.  PDL represents and warrants to GNE that:

(a)  The execution, delivery and performance of this Agreement by 
PDL will not, with or without notice, the passage of time or 
both, result in any violation of, be in conflict with, or 
constitute a default under any material contract, obligation or 
commitment to which PDL is a party or by which it is bound, or 
to PDL's knowledge, violate any statute, rule or governmental 
regulation applicable to PDL.

(b)  PDL has all requisite legal and corporate power and authority 
to enter into this Agreement and to carry out and perform its 
obligations under the terms of this Agreement.


Article VI

PATENT INFRINGEMENT

6.01.  Notification of Infringement.  PDL shall promptly notify GNE in 
writing of any actual or suspected infringement by third parties of any patent 
within the Licensed Patents of which PDL is aware, which notification shall 
specify in reasonable detail the nature of such actual or suspected 
infringement, and shall provide GNE with the available evidence, if any, of 
such infringement. 

6.02.  Enforcement of Licensed Patents.  GNE shall retain the sole 
right, at its sole discretion and expense, to enforce Licensed Patents against 
third party infringers.  

6.03.  No Warranty of Non-Infringement.  Nothing in this Agreement shall 
be construed as a representation made or warranty given by GNE that the 
practice by PDL or its Sublicensees of the license granted hereunder will not 
infringe the patent rights of any third party.

Article VII

CONFIDENTIALITY
The provisions of Article 9 of the Master Agreement are incorporated by 
reference as if set forth in their entirety herein.


Article VIII

TERM AND TERMINATION

8.01.  Term.  This Agreement shall come into force as of its Effective 
Date and shall continue in full force and effect on a country by country 
basis, unless earlier terminated as provided herein, until the expiration of 
the last to expire of the Licensed Patents.

8.02.  Termination for Breach.  GNE shall have the right to terminate 
this Agreement and the licenses granted hereunder upon thirty (30) days' prior 
written prior notice to PDL for PDL's material breach of this Agreement if PDL 
has failed to cure such breach within thirty (30) days of notice thereof; it 
being understood, however, that if within thirty (30) days after receipt of 
any such notice PDL shall have initiated and actively pursued remedy of its 
default, then the rights and licenses herein granted shall remain in force as 
if no breach or default had occurred on the part of PDL, unless such breach or 
default is not in fact remedied within a reasonable period of time.  If PDL 
disputes the existence of a material breach on its part or the failure to cure 
such breach within the period for cure, the provisions for resolution of a 
default shall be limited to those set forth in Section 11.6 of the Master 
Agreement.

8.03.  Insolvency.  Either Party may terminate this Agreement if, at any 
time, the other Party shall file in any court pursuant to any statute of any 
individual state or country, a petition in bankruptcy, insolvency or for 
reorganization or for an agreement among creditors or for the appointment of a 
receiver or trustee of the Party or of its assets, or if the other Party 
proposes a written agreement of composition or extension of its debts, or if 
the other Party shall be served with an involuntary petition against it filed 
in any insolvency proceeding, and such petition shall not be dismissed within 
sixty (60) days after the filing thereof, or if the other Party shall propose 
or be a Party to any dissolution or liquidation, or if the other Party shall 
make an assignment for the benefit of creditors.

8.04.  Termination by PDL.  PDL may terminate this Agreement at any time 
upon sixty (60) days' prior written notice to GNE. 

8.05.  Effect of Termination.  Termination of this Agreement in whole or 
in part for any reason shall not relieve PDL of its obligations to pay all 
fees and royalties that shall have accrued hereunder prior to the effective 
date of termination.  Termination of this Agreement as to PDL shall result in 
the termination of the licenses of PDL and all Sublicensees of PDL. 

 Article IX

MISCELLANEOUS PROVISIONS

9.01.  Limitations on Assignments.  Neither this Agreement nor any 
interests hereunder shall be assignable by either Party without the written 
consent of the other; provided, however, that either Party may assign this 
Agreement to any corporation or entity with which it may merge or consolidate, 
or to which it may transfer substantially all of its assets or all of its 
assets to which this Agreement relates without obtaining the consent of the 
other Party.


9.02.  Jurisdiction and Choice of Laws.  This Agreement shall be 
interpreted and construed under the laws of California, and PDL agrees to 
submit to the jurisdiction of California.

9.03.   Disputes.  The provisions of Section 11.6 of the Master 
Agreement are incorporated by reference as if set forth in their entirety 
herein.

9.04.  Relationship of the Parties.  Nothing in this Agreement is 
intended or shall be deemed to constitute a partnership, agency, employer-
employee, or joint venture relationship between the Parties.

9.05.  Further Acts and Instruments.  Each Party hereto agrees to 
execute, acknowledge and deliver such further instruments and to do all such 
other acts as may be necessary or appropriate to effect the purpose and intent 
of this Agreement.

9.06.  Entire Agreement.  This Agreement and the Master Agreement, 
constitute and contain the entire agreement of the Parties with respect to the 
Antigen and supersede any and all prior negotiations, correspondence, 
understandings and agreements between the Parties respecting the subject 
matter hereof.  In the event of any conflict between the terms of this 
Agreement and the Master Agreement with respect to the subject matter herein, 
the terms of this Agreement shall govern.  This Agreement may be amended or 
modified or one or more provisions thereof waived only by a written instrument 
signed by both of the Parties.

9.07.  Severability.  If in any jurisdiction any one or more of the 
provisions of this Agreement should for any reason be held by any court or 
authority having jurisdiction over this Agreement or any of the Parties hereto 
to be invalid, illegal or unenforceable, such provision or provisions shall be 
validly reformed to as nearly approximate the intent of the Parties as 
possible and if unreformable, the Parties shall meet to discuss what steps 
should be taken to remedy the situation; in other jurisdictions, this 
Agreement shall not be affected.

9.08.  Captions.  The captions to this Agreement are for convenience 
only and are to be of no force or effect in construing and interpreting the 
provisions of this Agreement.

9.09.  WARRANTIES.  The Parties represent and warrant that they have the 
power to enter into this agreement.  OTHERWISE, THE PARTIES EXPRESSLY DISCLAIM 
ALL WARRANTIES, EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION WARRANTIES OF 
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, OR NON-INFRINGEMENT.

9.10.  Notices.  Any notice, request, approval or other document 
required or permitted to be given under this Agreement shall be in writing and 
shall be deemed to have been sufficiently given when delivered in person, 
transmitted by telex, telecopier, telegraph or deposited in the mail, postage 
prepaid, for mailing by first class, certified or registered mail, return 
receipt 
requested, addressed as follows:

If to PDL, addressed to:

Protein Design Labs, Inc.
34801 Campus Drive 
Fremont, CA 94555 
Attn:  General Counsel

Facsimile number:  (510) 574-1500

If to GNE, addressed to:
Genentech, Inc.
One DNA Way
South San Francisco, CA 94080
Attn:  Corporate Secretary

Facsimile number:  (650) 225-8654 

or to such other address or addresses as may be specified from time to time in 
a written notice.

9.11.   Wire Transfer of Funds.  Unless otherwise specified in writing, 
all payments by PDL required hereunder shall be made by wire transfer at the 
written direction of GNE.

IN WITNESS WHEREOF,  GNE and PDL have caused this Agreement to be 
executed by their duly authorized representatives.

PROTEIN DESIGN LABS, INC.

By:                                              


Title:                                           


Date:                                            



GENENTECH, INC.

By:                                              


Title:                                           


Date:                                            



EXHIBIT A

Antigens


Licensed Patents

[Chimera Patents/Coexpression Patents]
[Both Chimera and Coexpression Patents]

EXHIBIT B

        Chimera and Coexpression Patents and Patent Applications

Country     Appln. Dt     Appln. No.     Patent No.           Patent Date

[                                                                        ]


EXHIBIT B

GNE Licensed Patents

The following are patents and patent applications (also known as the "Cabilly 
Patents") issued and filed in certain countries in the world and licensed as 
part of the GNE Licensed Patents under the Agreement:

Chimera and Coexpression Patents and Patent Applications

Country Appln. Dt        Appln. No.      Patent No.          Patent Date

[                                                                         ]

Exhibit C

Form of PDL License Agreement

Confidential Treatment Requested
PDL LICENSE AGREEMENT
between
PROTEIN DESIGN LABS, INC.
and
GENENTECH, INC.

This PDL License Agreement ("Agreement"), effective as of 
_____________ ("Effective Date"), is made by and between PROTEIN DESIGN 
LABS, INC., a Delaware corporation, having offices at 34801 Campus 
Drive, Fremont, CA 94555 (hereinafter "PDL") and GENENTECH, INC., a 
Delaware corporation, having offices at 1 DNA Way, South San Francisco, 
CA 94080 (hereinafter "GNE"). 
RECITALS
A.  GNE and PDL have entered into a Patent Licensing Master Agreement 
effective September __, 1998 (the "Master Agreement"), pursuant to which 
GNE may enter into this Agreement  with respect to a license under the 
"Queen Patents" for GNE's antibody products. 

B.      The Master Agreement provides GNE with the right to obtain a 
nonexclusive, worldwide, royalty-bearing license under the PDL Licensed 
Patents under the terms and conditions of this Agreement. 

        AGREEMENT
NOW THEREFORE, in consideration of the mutual covenants herein 
contained and intending to be legally bound, the parties agree as 
follows:

1.      DEFINITIONS

All references to Exhibits, Articles and Sections shall be 
references to Exhibits, Articles and Sections of this Agreement.  In 
addition, except as otherwise expressly provided herein, the following 
terms in this Agreement shall have the following meanings:

1.01  "Affiliate" means any corporation or other business entity 
controlled by, controlling, or under common control with another entity, 
with "control" meaning direct or indirect beneficial ownership of more 
than fifty percent (50%) of the voting stock of such corporation, or 
more than a fifty percent (50%) interest in the decision-making 
authority of such other unincorporated business entity; and a 
corporation in which the maximum amount of stock permitted by law to be 
held by another entity is beneficially owned by such other entity.  
Notwithstanding the foregoing, the term "Affiliate" under this Agreement 
with respect to GNE shall not include Roche Holdings, Inc., including 
its affiliated companies ("Roche"), until assignment of this Agreement 
to a member of such enterprise in accordance with Section 8.01.

1.02  "Antibody" means any antibody directed against an Antigen and 
shall include, without limitation, monospecific and bispecific 
antibodies (but only with respect to the Antigen for a bispecific 
antibody); less than full-length antibody forms such as Fv, Fab, and 
F(ab')2, single-chain antibodies and antibody conjugates bound to a 
toxin, label or other moiety, as well as any and all such constructs 
directed against the Antigen.

1.03  "Antigen" means the target molecule:  
_________________________________.

1.04  "Bulk Product" means Licensed Product supplied in a form other 
than Finished Product which can be converted into Finished Product.

1.05 "Combination Product(s)" means any product containing both a 
pharmaceutically active agent or ingredient which constitutes a Licensed 
Product and one or more other pharmaceutically active agents or 
ingredients which do not constitute Licensed Products.

1.06  "Europe" means the European Patent Convention Member Countries, 
including any successor organization and any additional countries that 
may join such organization from time to time during the term of this 
Agreement.

1.07  "Finished Product(s)" means any and all Licensed Products in 
form for use by an end user and not intended for further chemical or 
genetic manipulation or transformation.

1.08  "Licensed Product(s)" means an Antibody with respect to which 
GNE has either significant marketing rights or has done significant 
development (e.g., created, humanized or conducted preclinical or 
clinical development), the manufacture, import, use, offer to sell or 
sale of which would infringe, if not licensed under this Agreement, a 
Valid Claim.  

1.09  "Net Sales" means the aggregate gross revenues, whether in cash 
or in kind, derived by or payable from or on account of the sale or 
other transfer of Finished Products by GNE, Affiliates of GNE, GNE's 
sublicensees, Roche or Affiliates of GNE's sublicensees to an 
independent third party not an Affiliate of GNE, a sublicensee of GNE, 
Roche, or an Affiliate of a sublicensee of GNE, less [     ] to cover 
the following: (a) credits or allowances, if any, actually granted on 
account of price adjustments, recalls, rejection or return of items 
previously sold, (b) excise and sales taxes, duties or other taxes 
imposed on and paid with respect to such sales (excluding income or 
franchise taxes of any kind) and (c) outer packing, freight and freight 
insurance costs.  For all Finished Product(s) used or consumed by others 
than GNE, GNE shall be entitled to deduct [     ] from Net Sales in lieu 
of all other deductions such as taxes, shipping charges, packing, 
allowances and the like prior to calculating royalties due.  If GNE or 
any of its Affiliates or sublicensees receive non-cash consideration for 
any Finished Product sold or otherwise transferred to an independent 
third party not Roche or an Affiliate of the seller or transferor, the 
fair market value of such non-cash consideration on the date of such 
transfer as known to GNE, or as reasonably estimated by GNE if unknown, 
shall be included in the definition of Net Sales.  Net Sales shall not 
include Finished Products provided for bona fide clinical trial, 
evaluation, research or development purposes.

Net Sales for Bulk Products shall be calculated by multiplying 
the units of Finished Product to which such Bulk Product is reasonably 
anticipated to be converted by the established market price of the 
Finished Product on the date of sale of the Bulk Product.  By way of 
example and without limitation, units of Finished Product may be 
measured in grams or doses, as appropriate.

The method of calculating Net Sales of materials in form other 
than Finished Product or Bulk Product that can be converted into 
Finished Product shall be established by good faith discussion between 
PDL and GNE prior to the first sale or transfer of any such material by 
GNE to a non-Affiliate.

1.10  "Opposition Proceedings" means the legal proceedings at the 
European Patent Office ("EPO") initiated against EP patent 451,216B1 and 
terminating at the decision (oral and/or written) rendered by the 
Opposition Division ("OD") of the EPO, but excluding any proceedings 
resulting from the filing of an appeal to the OD's decision.

1.11  "PDL Licensed Patents" means the patents and patent 
applications identified on Exhibit A, and including any applications 
filed as of the Effective Date in the United States or any foreign 
jurisdiction.  PDL Licensed Patents shall include U.S. or foreign 
patents or patent applications which claim priority to any application 
to which a listed U.S. Patent also claims priority.  PDL Licensed 
Patents shall also include any foreign equivalents, addition, 
continuation, continuation-in-part or division of such patents or patent 
applications or any substitute applications therefor, any patent issued 
with respect to any such patent application, any reissue, extension or 
patent term extension of any such patent, and any confirmation patent or 
registration patent or patent of addition based on any such patent.  
[Drafting Note:  Update by PDL prior to delivery.]

1.12  "Territory" means either (a) worldwide, or (b) [         ]

1.13    "Valid Claim" means any claim in any PDL Licensed Patents which 
claim has neither expired or been disclaimed nor been held invalid or 
unenforceable by a court or other body of competent jurisdiction from 
which no appeal has been or may be taken.

2.      LICENSE

2.01    License Grant.  Subject to the fulfillment by GNE of all of the 
terms and conditions of this Agreement, PDL hereby grants to GNE and GNE 
hereby accepts a nonexclusive license in the Territory under the PDL 
Licensed Patents, including the right to grant sublicenses in accordance 
with Section 2.02, to make, have made, import, use, offer to sell and 
sell Licensed Products in the Territory.  PDL shall be free at its 
discretion to enter into additional agreements with additional licensees 
at any time and on terms solely of its choosing.

2.02    Limitation on Sublicenses; Notification. GNE shall have the 
right to grant sublicenses of its rights under Section 2.01 with respect 
to Licensed Products, provided that GNE shall grant such sublicenses 
only in connection with the assignment or license by GNE to such 
sublicensee of the right to use, make, have made, sell or otherwise 
transfer the Licensed Products.  GNE shall notify PDL of the identity of 
the sublicensee and scope of such sublicense promptly following the 
grant of a sublicense hereunder.  Notwithstanding the assignment or 
grant of a sublicense by GNE hereunder, GNE shall remain obligated to 
pay all royalties due to PDL with respect to the sale of Licensed 
Products by its assignee or sublicensee.  In addition, the grant 
of any sublicenses under Section 2.01 shall be on terms and conditions 
which are subject to and subordinate to the terms of this Agreement and 
GNE shall remain fully responsible to PDL for the performance of any and 
all such terms by its sublicensees.  

2.03    Updates to List of PDL Licensed Patents.  Upon written request 
of GNE (which request shall not be made more than once per calendar 
year), PDL agrees to provide a written update listing the PDL Licensed 
Patents, and such update shall constitute an amendment to Exhibit A.  
PDL may, at its option, furnish such update to GNE from time to time 
during the term of this Agreement as part of an update to the Master 
Agreement. 

2.04    No Other Rights.  GNE acknowledges and agrees that, except for 
the license expressly granted under Section 2.01, no rights to any other 
PDL patents or patent applications, or to any know-how, trade secrets or 
licenses are included in this Agreement or granted by implication, 
estoppel or otherwise.

2.05   [           ]

3.      PAYMENTS, ROYALTIES, REPORTS

3.01    Signing Fee. In consideration for the license granted by PDL 
under Article 2 of this Agreement, GNE shall pay to PDL, within fifteen 
(15) business days of the Effective Date of this Agreement, a 
nonrefundable signing and licensing fee in the sum of [One Million] [     
] United States Dollars (US$ [1,000,000] [     ]), increased annually 
beginning on January 1, 1999 and on each January 1 thereafter by an 
amount equal to the Consumer Price Index-U (or its successor) published 
by the U.S. Bureau of Labor Statistics ("CPI-U") for the prior year. GNE 
shall be entitled to deduct from the signing and licensing fee under 
this Agreement any amounts not previously credited and subject to credit 
under Section 3.03(a).  All such deductions shall be documented with any 
payments hereunder. [           ]

3.02  Annual Maintenance Fee.  In further consideration of the 
license granted under Article 2, within fifteen (15) business days of 
the [     ] anniversary of the Effective Date and each anniversary 
thereafter, GNE shall pay PDL a nonrefundable annual maintenance fee in 
the amount of [     ]. Such annual maintenance shall be fully creditable 
against royalties payable by GNE for the year with respect to which such 
annual maintenance fee is paid.  [             ]

3.03    Credits; Reductions.  [                   ]

3.04  Royalties to PDL.  In further consideration of the rights and 
licenses granted under Article 2, GNE shall pay to PDL a royalty of [     
] of the Net Sales of all GNE Licensed Products sold by GNE or its 
Affiliates or sublicensees or Roche in each country in the Territory 
until the later of the last date on which there is a Valid Claim that, 
but for the licenses granted to GNE under this Agreement, would be 
infringed by the making, using, importation, having made or sale of that 
Licensed Product in such country in the Territory or by the manufacture 
of Licensed Product in the country of manufacture. [Drafting Note:  
Include the following sentence if the licensed Antibody is a bispecific 
antibody:  "If the Antigen is the target of one arm of a bispecific 
antibody, then both arms shall be considered one Licensed Product for 
purposes of calculating royalties with respect to such Licensed Product, 
and GNE shall pay a royalty of [      ] of Net Sales GNE, its Affiliates 
or sublicensees or Roche."] 

3.05    Sales Among Affiliates.  Sales or other transfers of Licensed 
Products between and among GNE and any of its Affiliates, its 
sublicensees or Roche which are subsequently resold or to be resold by 
such Affiliates, sublicensees or Roche shall not be subject to royalty, 
but in such cases royalties shall accrue and be calculated on any 
subsequent sale or other transfer of such Licensed Products to a non-
Affiliate.

3.06    Combination Products.  Net Sales in a particular country in the 
Territory, in the case of Combination Products for which the 
pharmaceutically active agent or ingredient constituting a Licensed 
Product and each of the other pharmaceutically active agents or 
ingredients not constituting Licensed Products have established market 
prices in that country in the Territory when sold separately, shall be 
determined by multiplying the Net Sales for each such Combination 
Product by a fraction, the numerator of which shall be the established 
market price for the Finished Product(s) contained in the Combination 
Product and the denominator of which shall be the sum of the established 
market prices for the Finished Product(s) plus the established market 
prices for the other pharmaceutically active agents or ingredients 
contained in the Combination Product.  When such separate market prices 
are not established in that country in the Territory, then the parties 
shall negotiate in good faith to determine a fair and equitable method 
of calculating Net Sales in that country for the Combination Product in 
question.

3.07    Currency Conversion.  All amounts payable to PDL under this 
Agreement shall be payable in U.S. Dollars by wire transfer to a bank 
account designated by PDL.  In the case of royalties on Net Sales, all 
amounts payable shall first be calculated in the currency of sale and 
then converted into U.S. Dollars using the average of the daily exchange 
rates for such currency quoted by Citibank, N.A. for each of the last 
five (5) banking days of each calendar quarter.

3.08    Reports.  
(a)     Current Reports.  GNE agrees to make written reports and royalty 
payments to PDL within sixty (60) days after the close of each calendar 
quarter during the term of this Agreement, beginning with the calendar 
quarter in which the date of first commercial sale or other transfer of 
a Licensed Product by GNE, its Affiliates. Sublicensees or Roche, 
provided that reports with respect to sales by sublicensees or Roche 
shall include only those sales as to which royalty reports were received 
by GNE during such calendar quarter.  These reports shall be certified 
by an officer of GNE and shall state for the calendar quarter in 
question:  (1) Identification on a country-by-country basis of the 
Licensed Product, (2) Net Sales in the Territory, (3) the quantities of 
Licensed Products sold or manufactured in such quarter in the Territory, 
(4) applicable offsets and (5) the net royalty due to PDL thereon 
pursuant to this Article 3.  No later than at the time of the making of 
each such report, GNE shall make any payment due to PDL of royalties for 
the period covered by such report.
(b)     Termination Report.  For each Licensed Product, GNE also agrees 
to make a written report to PDL within ninety (90) days after the date 
on which GNE, its Affiliates or sublicensees last sell or otherwise 
transfer that Licensed Product in the Territory stating in such report 
the same information required by quarterly reports for all such Licensed 
Products made, sold or otherwise disposed of which were not previously 
reported to PDL.

(c)     Notification of Marketing Approval.  GNE agrees to notify 
PDL in writing within sixty (60) days after the date on which GNE, 
its Affiliates or sublicensees or Roche obtain marketing approval of 
a Licensed Product in any country in the Territory.  Such notice 
shall specify the country in which marketing approval was obtained 
and the date of such approval.

3.09    Inspection.  GNE agrees to keep, and to require any of its 
Affiliates or sublicensees to keep, clear, accurate and complete records 
for a period of at least three (3) years for each reporting period in 
which Net Sales occur showing the sales of Licensed Products in the 
Territory in sufficient detail to enable the royalties payable hereunder 
to be determined, and further agrees to permit its books and records, 
and to require any of its Affiliates or sublicensees to permit their 
books and records, to be examined by an independent accounting firm 
selected by PDL and reasonably satisfactory to GNE from time-to-time, 
but not more than once a year.  Such examination is to be made at the 
expense of PDL, except in the event that the results of the audit reveal 
that GNE underpaid PDL by [     ] or more, then GNE shall pay any 
deficiency plus interest for such overdue royalties in accordance with 
Section 3.11 hereof, and the audit fees shall be paid by GNE.  Any such 
discrepancies will be promptly corrected by a payment or refund, as 
appropriate.

3.10    Withholding.  
(a)     Fees.  The amounts payable under Sections 3.01 and 3.02 shall 
represent the actual proceeds to be received by PDL, net of any 
withholding or other taxes or levies that may be applicable to such 
payments.  PDL agrees to reasonably cooperate with GNE in obtaining a 
refund of any withholding taxes or levies paid by GNE, if any, with 
respect to any payments to PDL hereunder.  In the event that PDL is 
successful in obtaining any refund of tax withholding amounts paid by 
GNE under this Agreement, PDL agrees to promptly remit such refund 
amount to GNE.
(b)     Royalty Payments.  GNE may withhold from royalties due to PDL 
amounts for payment of any income or withholding tax that GNE has 
actually paid to any taxing authority with respect to royalty amounts 
due to PDL hereunder in the Territory. GNE shall promptly provide PDL 
with official tax receipts or other documentation sufficient to enable 
PDL to satisfy U.S. tax authorities with respect to PDL's application 
for a for-tax credit.  GNE agrees to reasonably cooperate with PDL in 
obtaining a foreign tax credit in the U.S. with respect to royalties due 
to PDL on the sale or manufacture of Licensed Products.

3.11    Interest on Overdue Royalties.  GNE shall be liable for interest 
on any overdue royalties, at the rate of ten percent (10%) per annum, or 
the highest rate allowed by law, whichever is less, commencing on the 
date such royalties are due until paid. 

3.12  Royalties to Third Parties.  GNE acknowledges and agrees that 
other licenses may be required from third parties with respect to the 
development, manufacture, importation, use, and sale of any Licensed 
Product under this Agreement, and that GNE shall be responsible for any 
royalties and other payments with respect to those license rights.  In 
no event shall GNE have a right to credit against, reduce or otherwise 
offset any royalty or payment obligations to such third parties against 
royalty amounts payable to PDL under the this Agreement.

4.      INFRINGEMENT OF PDL LICENSED PATENTS

4.01    Suits.  PDL shall have no obligation hereunder to institute any 
action, suit or other proceeding against third parties for infringement 
of any PDL Licensed Patents or to defend any action, suit or proceeding 
brought by a third party which challenges or concerns the validity or 
enforceability of any PDL Licensed Patents in the Territory. Any monies 
recovered from alleged infringers shall be retained by PDL.

4.02    Notification of Third Party Infringements.  GNE shall promptly 
notify PDL in writing of any actual or suspected infringement by third 
parties of any PDL Licensed Patent, which notification shall specify in 
reasonable detail the nature of such actual or suspected infringement of 
which GNE is aware and shall provide PDL with the available evidence, if 
any of such infringement.

5.      REPRESENTATIONS AND WARRANTIES; DISCLAIMERS; 
        INDEMNIFICATION

5.01  Representations of GNE.  GNE represents and warrants to PDL 
that:

(a)  The execution, delivery and performance of this Agreement by GNE 
will not, with or without notice, the passage of time or both, result 
in any violation of, be in conflict with, or constitute a default 
under any material contract, obligation or commitment to which GNE is 
a party or by which it is bound, or to GNE's knowledge, violate any 
statute, rule or governmental regulation applicable to GNE.

(b)  GNE has all requisite legal and corporate power and authority to 
enter into this Agreement on behalf of itself and its Affiliates and 
to carry out and perform its obligations under the terms of this 
Agreement.  

5.02  Representations of PDL.  PDL represents and warrants to GNE 
that:

(a)  The execution, delivery and performance of this Agreement by PDL 
will not, with or without notice, the passage of time or both, result 
in any violation of, be in conflict with, or constitute a default 
under any material contract, obligation or commitment to which PDL is 
a party or by which it is bound, or to PDL's knowledge, violate any 
statute, rule or governmental regulation applicable to PDL.

(b)  PDL has all requisite legal and corporate power and authority to 
enter into this Agreement and to carry out and perform its 
obligations under the terms of this Agreement.

5.03    Disclaimers.  Nothing in this Agreement shall be construed as 
(a) a warranty or representation by PDL as to the validity, 
enforceability or scope of any PDL Licensed Patents; (b) a requirement 
that PDL file any patent application, or to secure any patent or patent 
rights, or maintain any patent in force, or to provide copies of patent 
applications to GNE or its Affiliates or sublicensees, or to disclose 
any inventions described or claimed in such patent applications; or (c) 
a warranty or representation by PDL that any Licensed Product made, 
used, imported, sold or otherwise disposed of under the license granted 
in this Agreement is or will be free from infringement of patents, 
copyrights, trademarks, trade secrets or other rights of third parties.  
GNE acknowledges and agrees that any royalties or payments that may be 
due to third parties in order for GNE to make, have made, import, use, 
sell or otherwise dispose of Licensed Products shall be the sole 
responsibility of GNE.

5.04    No Other Warranties.  EXCEPT AS SPECIFICALLY SET FORTH IN 
ARTICLE 5, PDL MAKES NO REPRESENTATIONS OR WARRANTIES OF ANY KIND, 
EITHER EXPRESS OR IMPLIED, WITH RESPECT TO PDL LICENSED PATENTS OR ANY 
CELL LINES, ANTIBODIES OR LICENSED PRODUCTS DEVELOPED BY GNE UNDER THE 
LICENSE SET FORTH IN THIS AGREEMENT AND PDL FURTHER MAKES NO EXPRESS OR 
IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR 
PURPOSE, OR THAT THE USE OF OR PRACTICE UNDER PDL LICENSED PATENTS OR 
ANY CELL LINES, ANTIBODIES, LICENSED PRODUCTS OR OTHER MATERIALS 
DEVELOPED BY GNE UNDER THE LICENSE SET FORTH IN THIS AGREEMENT WILL NOT 
INFRINGE ANY THIRD PARTY RIGHTS.

5.05    Indemnification.  GNE shall at all times, during the term of 
this Agreement and thereafter, indemnify and hold harmless PDL and its 
Affiliates, sublicensees, directors, officers, agents and employees from 
any claim, proceeding, loss, expense, and liability of any kind 
whatsoever (including but not limited to those resulting from death, 
personal injury, illness or property damage and including legal expenses 
and reasonable attorneys' fees) arising out of or resulting from (a) any 
claim of patent infringement (direct or contributory) or inducing patent 
infringement with respect to the activities of GNE or its Affiliates or 
sublicensees, and (b) the development, manufacture, holding, use, 
testing, advertisement, sale or other disposition by GNE, its Affiliates 
or sublicensees, or any distributor, customer or representative thereof 
or any one in privity therewith, of any Licensed Product; provided, 
however, that PDL shall promptly notify GNE of such claim, proceeding, 
loss, expense or liability and GNE, at GNE's cost, shall have sole 
control over the defense, including settlement of any claim or action, 
with full cooperation from PDL.

6.      CONFIDENTIALITY
The provisions of Article 9 of the Master Agreement are incorporated 
by reference as if set forth in their entirety herein.

7.      TERM AND TERMINATION

7.01    Term.  Unless earlier terminated as provided in this Article 7, 
this Agreement shall come into force on the Effective Date and shall 
continue until the last to expire of the PDL Licensed Patents.  
Thereafter, this Agreement shall terminate and all licenses or 
sublicenses granted hereunder shall become fully-paid licenses.  

7.02    Termination.  
(a)     This Agreement may be terminated on sixty (60) days prior 
written notice by GNE.
(b)     If GNE shall at any time default in the payment of any royalty, 
or the making of any report hereunder, or shall commit any material 
breach of any covenant or agreement herein contained or shall make any 
false report, and shall fail to have initiated and actively pursued 
remedy of any such default or breach within thirty (30) days after 
receipt of written notice thereof by the other party, PDL may, at its 
option, cancel this Agreement and revoke any rights and licenses herein 
granted and directly affected by the default or breach by notice in 
writing to such effect, but such act shall not prejudice PDL's rights to 
recover any royalty or other sums due at the time of such cancellation, 
it being understood, however, that if within thirty (30) days after 
receipt of any such notice GNE shall have initiated and actively pursued 
remedy of its default, then the rights and licenses herein granted shall 
remain in force as if no breach or default had occurred on the part of 
GNE, unless such breach or default is not in fact remedied within a 
reasonable period of time.  If GNE disputes the existence of a default 
or material breach or making a false report or the failure to pursue a 
remedy or to remedy the default or breach, the provisions for resolution 
of a default shall be limited to those set forth in Section 11.6 of the 
Master Agreement.
(c)     This Agreement may be terminated by either party upon the 
occurrence of any of the following which is not stayed or vacated within 
sixty (60) days of such occurrence:  (i) petition in bankruptcy filed by 
or against the other party; (ii) adjudication of the other party as 
bankrupt or insolvent; (iii) appointment of a liquidator, receiver or 
trustee for all or a substantial part of the other party's property; or 
(iv) an assignment for the benefit of creditors of the other party.
(d)     With the exception of GNE's participation in the Opposition 
Proceedings, in the event that GNE challenges a PDL Licensed Patent in 
any country the license granted under this Agreement may be terminated 
by PDL, to the extent permitted under applicable law, upon thirty (30) 
days prior written notice and the Territory shall exclude a license in 
such country effective as of the date of PDL's written notice. 

7.03    No Waiver.  The right of either party to terminate this 
Agreement as provided herein shall not be affected in any way by its 
waiver of any previous failure to perform hereunder or by its failure to 
take action with respect thereto.

7.04    Survival.  Termination for any reason hereunder shall not affect 
any accrued rights or obligations of the parties arising in any manner 
under this Agreement as of the date of termination.  In any event, the 
rights and obligations, including without limitation any accrued payment 
obligations, under Articles 3, 5 and 6 shall survive any termination of 
this Agreement.

8.      MISCELLANEOUS

8.01  Assignment.  This Agreement may not be assigned by either party 
without the prior written consent of the other, except that either may 
assign this Agreement without consent to a party which acquires all or 
substantially all of that portion of the business to which this 
Agreement pertains, whether by merger, sale of assets or otherwise.  A 
merger or consolidation shall be deemed to constitute an assignment.

8.02 Disputes.   The provisions of Section 11.6 of the Master 
Agreement are incorporated by reference as if set forth in their 
entirety herein.

8.03    Severability.  If any provision of this Agreement is declared 
invalid by a court of law resort or by any court, the decision of which 
an appeal is not taken within the time provided by law, then and in such 
event, this Agreement will be deemed to have been terminated only as to 
the portion thereof which relates to the provision invalidated by that 
decision and only in the relevant jurisdiction, but this Agreement, in 
all other respects and all other jurisdictions, will remain in force; 
provided, however, that if the provision so invalidated is essential to 
the Agreement as a whole, then the parties shall negotiate in good faith 
to amend the terms hereof as nearly as practical to carry out the 
original interest of the parties, and, failing such amendment, either 
party may submit the matter to a court of competent jurisdiction for 
resolution.

8.04    Notices.  Any notice or report required or permitted to be given 
under this Agreement shall be in writing and shall be sent by expedited 
delivery or telecopied and confirmed by mailing as follows (or to such 
other address as may be specified in writing) and shall be effective 
three (3) days after such delivery:

If to PDL:   Protein Design Labs, Inc.
             34801 Campus Drive                              
             Fremont, CA.  94555                     
             Attention: General Counsel
             Facsimile number:  (510) 574-1500

If to GNE:   Genentech, Inc.
             1 DNA Way
             South San Francisco, California USA 94080
             Attn:  Corporate Secretary
             Facsimile number:  (650) 225-8654

8.05    Choice of Law.  The validity, performance, construction, and 
effect of this Agreement shall be governed by the laws of the State of 
California which are applicable to contracts between California 
residents to be performed wholly within California.

8.06    Waiver.  None of the terms, covenants and conditions of this 
Agreement can be waived except by the written consent of the party 
waiving compliance.

8.07    Force Majeure.  Neither party shall be responsible to the other 
for failure or delay in performing any of its obligations under this 
Agreement or for other non-performance hereof provided that such delay 
or non-performance is occasioned by a cause beyond the reasonable -
control and without fault or negligence of such party, including, but 
not limited to earthquake, fire, flood, explosion, discontinuity in the 
supply of power, court order or governmental interference, act of God, 
strike or other labor trouble and provided that such party will inform 
the other party as soon as is reasonably practicable and that it will 
entirely perform its obligations immediately after the relevant cause 
has ceased its effect.

8.08    Headings.  The captions used herein are inserted for convenience 
of reference only and shall not be construed to create obligations, 
benefits, or limitations.

8.09    Entire Agreement.  This Agreement and the Master Agreement 
constitute the entire Agreement between the parties hereto with respect 
to the Antigen and supersede all previous Agreements, whether written or 
oral. In the event of any conflict between the terms of this Agreement 
and the Master Agreement with respect to the subject matter herein, the 
terms of this Agreement shall govern.  This Agreement shall not be 
changed or modified orally, but only by an instrument in writing signed 
by both parties.

8.10  Counterparts.  This Agreement may be executed in counterparts, 
all of which taken together shall be regarded as one and the same 
instrument.

 IN WITNESS WHEREOF, the parties hereto have duly executed this 
Agreement as of the date first above written.

PROTEIN DESIGN LABS, INC.                       GENENTECH, INC.


By:                                             By:      

Title:______________________                    Title:______________________ 


Confidential Treatment Requested

Exhibit A

PDL Licensed Patents 

The following are patents and patent applications (also known as the 
"Queen Patents") issued and filed in certain countries in the world and 
licensed as part of the PDL Licensed Patents under the Agreement:

1.  The following issued U.S. patents and U.S. patent applications:  

No. 5,693,089, "Humanized Immunoglobulins," issued December 17, 
1996. 

No. 5,693,761, "Polynucleotides Encoding Improved Humanized 
Immunoglobulins," issued December 2, 1997.

No. 5,693,762, "Humanized Immunoglobulins," issued December 2, 
1997.

[       ] 

2.  The following foreign patents and patent applications (as of August 
1998):

Patent No.                     Country                      Title*

Issued 647383                   Australia            "Novel Immunoglobulins,
                                                      Their Production and Use"
Issued  0451216                 Austria                         "
Issued 0451216                  Belgium                         "
Issued 970016                   Brazil                          "
Issued 61095                    Bulgaria                        "
Issued 296964                   Germany                         "
Issued FR0451216                France                          "
Issued GB 0451216               Great Britain                   "
Issued 1001050                  Greece                          "
Issued  211174                  Hungary                         "
Issued IT O451216               Italy                           "
Issued LU O451216               Luxembourg                      "
Issued 92.2146                  Monaco                          "
Issued NL 0451216               Netherlands                     "
Issued 231984                   New Zealand                     "
Issued 132068                   Pakistan                        "
Issued 29729                    Philippines                     "
Issued  92753                   Portugal                        "
Issued SG O451216               Singapore                       "
Issued 89/9956                  South Africa                    "
Issued  2081974 T3              Spain                           "
Issued SE O451216               Sweden                          "
Issued CHO 451216               Switzerland                     "
Issued 50034                    Taiwan                          "
[       ]
Issued 671949                   Australia         "Humanized Immunoglobulins,
                                                   Their Production and Use"
Issued 0451 216B1               European                        "
[       ]

*Exact titles may differ in different countries.


Exhibit D

PDL Licensed Patents 

The following are patents and patent applications (also known as the 
"Queen patents") issued and filed in certain countries in the world and 
licensed as part of the PDL Licensed Patents under the Agreement:

1.  The following issued U.S. patents and U.S. patent applications:  

No. 5,693,089, "Humanized Immunoglobulins," issued December 17, 
1996. 

No. 5,693,761, "Polynucleotides Encoding Improved Humanized 
Immunoglobulins," issued December 2, 1997.

No. 5,693,762, "Humanized Immunoglobulins," issued December 2, 
1997.

[       ]  

2.  The following foreign patents and patent applications (as of August 
1998):

Patent No.                      Country                    Title*

Issued 647383                   Australia           "Novel Immunoglobulins,
                                                     Their Production and Use"
Issued  0451216                 Austria                       "
Issued 0451216                  Belgium                       "
Issued 61095                    Bulgaria                      "
Issued 970016                   Brazil                        "
Issued 296964                   Germany                       "
Issued FR0451216                France                        "
Issued GB 0451216               Great Britain                 "
Issued 1001050                  Greece                        "
Issued  211174                  Hungary                       "
Issued IT O451216               Italy                         "
Issued LU O451216               Luxembourg                    "
Issued 92.2146                  Monaco                        "
Issued NL 0451216               Netherlands                   "
Issued 231984                   New Zealand                   "      
Issued 132068                   Pakistan                      "
Issued 29729                    Philippines                   "
Issued  92758                   Portugal                      "
Issued SG O451216               Singapore                     "
Issued 89/9956                  South Africa                  "
Issued  2081974 T3              Spain                         "
Issued SE O451216               Sweden                        "    
Issued CHO 451216               Switzerland                   "
Issued 50034                    Taiwan                        "
[       ]
Issued 671949                   Australia          "Humanized Immunoglobulins,
                                                    Their Production and Use"
Issued 0451 216B1               European                      "
[       ]

Exhibit E

Form of Press Release

For Immediate Release

Contacts:
Protein Design Labs, Inc.
Robert L. Kirkman, M.D.
Vice President, Business Development and 
Corporate Communications
510-574-1419
Genentech, Inc.
Laura Leber (media contact)
650-225-5759
Susan Bentley (investor contact)
650-225-1034

PROTEIN DESIGN LABS AND GENENTECH ANNOUNCE AGREEMENT FOR ANTIBODY 
PATENTS 

Fremont, CA and South San Francisco, CA [September 28, 1998]  
Protein Design Labs, Inc. (PDL) (Nasdaq: PDLI) and Genentech, Inc. 
(NYSE: GNE) today announced an innovative agreement to cross-license 
rights to certain intellectual property in the field of monoclonal 
antibodies. Under the agreement, Genentech will pay a $6.0 million 
upfront, non-creditable, non-refundable fee to PDL, and PDL will pay 
Genentech a $1.0 million upfront, non-creditable, non-refundable fee, 
for rights to license particular antibodies under specified patents and 
patent applications held by the other company. 

"This unique agreement between two leading biotechnology companies 
demonstrates that intellectual property rights can be used in a positive 
manner in the competitive pharmaceutical environment," said Arthur D. 
Levinson, Ph.D., Genentech President and Chief Executive Officer, and 
Laurence Jay Korn, Ph.D, PDL Chief Executive Officer and Chairperson, in 
a joint statement.  "Rather than create new obstacles, our agreement 
addresses potential proprietary rights issues and allows each company to 
pursue development of new products to meet important medical needs."  

PDL has U.S. and European patents and patent applications which it 
believes cover most humanized antibodies and has granted licenses under 
its patents to numerous pharmaceutical and biotechnology companies. 
Genentech has patents and patent applications in the U.S. and elsewhere 
which it believes cover the expression of recombinant antibodies and 
certain chimeric and humanized antibodies, and also has issued licenses 
under these patents and patent applications to numerous other companies. 

Under the agreement, Genentech and PDL each may obtain nonexclusive 
licenses under the other company's relevant patents or applications upon 
payment of a license fee of at least $1.0 million per antibody. Licensed 
antibodies will bear royalties on sales, if any.  Initially, each 
company may select up to six antibodies. The number of licensed 
antibodies and the term of the agreement may be increased for additional 
fees.

Genentech has several monoclonal antibodies in its development 
portfolio. Herceptin[R] (trastuzumab), Genentech's humanized anti-HER2 
antibody for the treatment of breast cancer, was recently recommended 
for approval by a U.S. Food and Drug Administration advisory committee. 
Other humanized antibodies in clinical development at Genentech include 
anti-IgE for allergic asthma and allergic rhinitis (Phase III), anti-
VEGF for cancer (Phase II), anti-CD18 for acute myocardial infarction 
(Phase II), and anti-CD11a for psoriasis (Phase II).

PDL antibodies in clinical development include SMARTT (humanized) Anti-
CD3 for transplantation and autoimmune disease (Phase I), OstavirT for 
chronic hepatitis B (Phase IIa) and SMART M195 for myeloid leukemias 
(Phase II/III). Zenapax[R] (daclizumab), a humanized antibody created by 
PDL, is currently marketed in the U.S. and several other countries by 
PDL corporate partner Hoffmann-La Roche Inc. and affiliates (Roche) for 
the prophylaxis of acute organ rejection in patients receiving renal 
transplants. PDL receives royalties on Zenapax sales. Independently from 
this agreement, Roche has obtained a royalty-free license from Genentech 
under certain patents for Zenapax.  

        Genentech, Inc. is a leading biotechnology company that discovers, 
develops, manufactures and markets human pharmaceuticals for significant 
unmet medical needs. Eleven of the currently marketed biotechnology 
products stem from Genentech science, six of which Genentech markets 
directly in the U.S. 

        Protein Design Labs, Inc. is a leader in the development of 
humanized and human antibodies to prevent or treat various disease 
conditions. PDL currently has antibodies under development in the areas 
of transplantation, autoimmunity and inflammatory conditions, cancer and 
infectious disease.  PDL also has a program to develop novel 
antimicrobial agents based on the identification of microbial genes 
expressed when microbes infect a host.

Protein Design Labs, SMART, Ostavir and the PDL logo are registered U.S. 
trademarks of Protein Design Labs, Inc. Herceptin is a registered U.S. 
trademark of Genentech, Inc.  Zenapax is a registered U.S. trademark of 
Hoffmann-La Roche Inc.

 
 
5 THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION FROM THE ACCOMPANYING FINANCIAL STATEMENTS AND IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENT 1,000 3-MOS DEC-31-1998 JUL-01-1998 SEP-30-1998 44,740 78,106 9,808 0 0 132,654 22,169 0 178,479 10,891 0 0 0 186 167,402 178,479 11,878 11,878 0 0 11,189 0 0 689 0 689 0 0 0 689 $0.04 $0.04